ZBTB17

Zinc finger and BTB domain containing 17
Rendering based on PDB 2Q81​.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2LVR​, 2LVT​, 2LVU​, 2M0D​, 2M0E​, 2M0F​, 2Q81​, 3M52​, 4U2M​, 4U2N​
Identifiers
Symbols	ZBTB17 ; MIZ-1; ZNF151; ZNF60; pHZ-67
External IDs	OMIM: 604084 MGI: 107410 HomoloGene: 2575 GeneCards: ZBTB17 Gene
Gene ontology Molecular function • DNA binding • transcription factor activity, sequence-specific DNA binding • protein binding • metal ion binding Cellular component • nucleoplasm Biological process • gastrulation with mouth forming second • transcription, DNA-templated • ectoderm development • endoplasmic reticulum unfolded protein response • IRE1-mediated unfolded protein response • cellular protein metabolic process • negative regulation of cell cycle • positive regulation of transcription, DNA-templated • regulation of mitophagy • positive regulation of protein targeting to mitochondrion Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7709	22642
Ensembl	ENSG00000116809	ENSMUSG00000006215
UniProt	Q13105	Q60821
RefSeq (mRNA)	NM_001242884	NM_009541
RefSeq (protein)	NP_001229813	NP_033567
Location (UCSC)	Chr 1: 15.94 – 15.98 Mb	Chr 4: 141.44 – 141.47 Mb
PubMed search

Zinc finger and BTB domain-containing protein 17 is a protein that in humans is encoded by the ZBTB17 gene.^[1]

Interactions

ZBTB17 has been shown to interact with TOPBP1,^[2] Host cell factor C1^[3] and Myc.^[4][5]

References

1. "Entrez Gene: ZBTB17 zinc finger and BTB domain containing 17".
2. Herold S, Wanzel M, Beuger V, Frohme C, Beul D, Hillukkala T, Syvaoja J, Saluz HP, Haenel F, Eilers M (Sep 2002). "Negative regulation of the mammalian UV response by Myc through association with Miz-1". Molecular Cell 10 (3): 509–21. doi:10.1016/S1097-2765(02)00633-0. PMID 12408820.
3. Piluso D, Bilan P, Capone JP (Nov 2002). "Host cell factor-1 interacts with and antagonizes transactivation by the cell cycle regulatory factor Miz-1". The Journal of Biological Chemistry 277 (48): 46799–808. doi:10.1074/jbc.M206226200. PMID 12244100.
4. Staller P, Peukert K, Kiermaier A, Seoane J, Lukas J, Karsunky H, Möröy T, Bartek J, Massagué J, Hänel F, Eilers M (Apr 2001). "Repression of p15INK4b expression by Myc through association with Miz-1". Nature Cell Biology 3 (4): 392–9. doi:10.1038/35070076. PMID 11283613.
5. Peukert K, Staller P, Schneider A, Carmichael G, Hänel F, Eilers M (Sep 1997). "An alternative pathway for gene regulation by Myc". The EMBO Journal 16 (18): 5672–86. doi:10.1093/emboj/16.18.5672. PMC 1170199. PMID 9312026.

Further reading

• Lichter P, Bray P, Ried T, Dawid IB, Ward DC (Aug 1992). "Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes". Genomics 13 (4): 999–1007. doi:10.1016/0888-7543(92)90013-I. PMID 1505991.
• Bray P, Lichter P, Thiesen HJ, Ward DC, Dawid IB (Nov 1991). "Characterization and mapping of human genes encoding zinc finger proteins". Proceedings of the National Academy of Sciences of the United States of America 88 (21): 9563–7. doi:10.1073/pnas.88.21.9563. PMC 52758. PMID 1946370.
• Tommerup N, Vissing H (May 1995). "Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders". Genomics 27 (2): 259–64. doi:10.1006/geno.1995.1040. PMID 7557990.
• Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Wu L, Wu H, Ma L, Sangiorgi F, Wu N, Bell JR, Lyons GE, Maxson R (Jul 1997). "Miz1, a novel zinc finger transcription factor that interacts with Msx2 and enhances its affinity for DNA". Mechanisms of Development 65 (1-2): 3–17. doi:10.1016/S0925-4773(97)00032-4. PMID 9256341.
• Schneider A, Peukert K, Eilers M, Hänel F (1997). "Association of Myc with the zinc-finger protein Miz-1 defines a novel pathway for gene regulation by Myc". Current Topics in Microbiology and Immunology 224: 137–46. doi:10.1007/978-3-642-60801-8_14. PMID 9308237.
• Peukert K, Staller P, Schneider A, Carmichael G, Hänel F, Eilers M (Sep 1997). "An alternative pathway for gene regulation by Myc". The EMBO Journal 16 (18): 5672–86. doi:10.1093/emboj/16.18.5672. PMC 1170199. PMID 9312026.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Sui D, Wilson JE (Oct 2000). "Interaction of insulin-like growth factor binding protein-4, Miz-1, leptin, lipocalin-type prostaglandin D synthase, and granulin precursor with the N-terminal half of type III hexokinase". Archives of Biochemistry and Biophysics 382 (2): 262–74. doi:10.1006/abbi.2000.2019. PMID 11068878.
• Staller P, Peukert K, Kiermaier A, Seoane J, Lukas J, Karsunky H, Möröy T, Bartek J, Massagué J, Hänel F, Eilers M (Apr 2001). "Repression of p15INK4b expression by Myc through association with Miz-1". Nature Cell Biology 3 (4): 392–9. doi:10.1038/35070076. PMID 11283613.
• Ziegelbauer J, Shan B, Yager D, Larabell C, Hoffmann B, Tjian R (Aug 2001). "Transcription factor MIZ-1 is regulated via microtubule association". Molecular Cell 8 (2): 339–49. doi:10.1016/S1097-2765(01)00313-6. PMID 11545736.
• Tussie-Luna MI, Michel B, Hakre S, Roy AL (Nov 2002). "The SUMO ubiquitin-protein isopeptide ligase family member Miz1/PIASxbeta /Siz2 is a transcriptional cofactor for TFII-I". The Journal of Biological Chemistry 277 (45): 43185–93. doi:10.1074/jbc.M207635200. PMID 12193603.
• Piluso D, Bilan P, Capone JP (Nov 2002). "Host cell factor-1 interacts with and antagonizes transactivation by the cell cycle regulatory factor Miz-1". The Journal of Biological Chemistry 277 (48): 46799–808. doi:10.1074/jbc.M206226200. PMID 12244100.
• Zhang H, Li Z, Viklund EK, Strömblad S (Sep 2002). "P21-activated kinase 4 interacts with integrin alpha v beta 5 and regulates alpha v beta 5-mediated cell migration". The Journal of Cell Biology 158 (7): 1287–97. doi:10.1083/jcb.200207008. PMC 2173231. PMID 12356872.
• Herold S, Wanzel M, Beuger V, Frohme C, Beul D, Hillukkala T, Syvaoja J, Saluz HP, Haenel F, Eilers M (Sep 2002). "Negative regulation of the mammalian UV response by Myc through association with Miz-1". Molecular Cell 10 (3): 509–21. doi:10.1016/S1097-2765(02)00633-0. PMID 12408820.
• Wu S, Cetinkaya C, Munoz-Alonso MJ, von der Lehr N, Bahram F, Beuger V, Eilers M, Leon J, Larsson LG (Jan 2003). "Myc represses differentiation-induced p21CIP1 expression via Miz-1-dependent interaction with the p21 core promoter". Oncogene 22 (3): 351–60. doi:10.1038/sj.onc.1206145. PMID 12545156.
• Bowen H, Lapham A, Phillips E, Yeung I, Alter-Koltunoff M, Levi BZ, Perry VH, Mann DA, Barton CH (Sep 2003). "Characterization of the murine Nramp1 promoter: requirements for transactivation by Miz-1". The Journal of Biological Chemistry 278 (38): 36017–26. doi:10.1074/jbc.M304301200. PMID 12840021.
• Sakurai T, Itoh K, Higashitsuji H, Nagao T, Nonoguchi K, Chiba T, Fujita J (Apr 2004). "A cleaved form of MAGE-A4 binds to Miz-1 and induces apoptosis in human cells". The Journal of Biological Chemistry 279 (15): 15505–14. doi:10.1074/jbc.M310437200. PMID 14739298.
• Lehner B, Sanderson CM (Jul 2004). "A protein interaction framework for human mRNA degradation". Genome Research 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.

External links

• ZBTB17 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.