BATF (gene)

Basic leucine zipper transcription factor, ATF-like
Identifiers
Symbols BATF ; B-ATF; BATF1; SFA-2; SFA2
External IDs OMIM: 612476 MGI: 1859147 HomoloGene: 4666 GeneCards: BATF Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 10538 53314
Ensembl ENSG00000156127 ENSMUSG00000034266
UniProt Q16520 O35284
RefSeq (mRNA) NM_006399 NM_016767
RefSeq (protein) NP_006390 NP_058047
Location (UCSC) Chr 14:
75.52 – 75.55 Mb		 Chr 12:
85.69 – 85.71 Mb
PubMed search

Basic leucine zipper transcription factor, ATF-like, also known as BATF, is a protein which in humans is encoded by the BATF gene.[1][2][3]

Function

The protein encoded by this gene is a nuclear basic leucine zipper (bZIP) protein that belongs to the AP-1/ATF superfamily of transcription factors. The leucine zipper of this protein mediates dimerization with members of the Jun family of proteins. This protein is thought to be a negative regulator of AP-1/ATF transcriptional events.[3]

Mice without the BATF gene (BATF knockout mice) lacked a type of inflammatory immune cell (Th17) and were resistant to conditions that normally induces an autoimmune condition similar to multiple sclerosis.[4]

Interactions

BATF (gene) has been shown to interact with IFI35.[5]

References

  1. ↑ Dorsey MJ, Tae HJ, Sollenberger KG, Mascarenhas NT, Johansen LM, Taparowsky EJ (December 1995). "B-ATF: a novel human bZIP protein that associates with members of the AP-1 transcription factor family". Oncogene 11 (11): 2255–65. PMID 8570175.
  2. ↑ Hasegawa H, Utsunomiya Y, Kishimoto K, Tange Y, Yasukawa M, Fujita S (May 1996). "SFA-2, a novel bZIP transcription factor induced by human T-cell leukemia virus type I, is highly expressed in mature lymphocytes". Biochem. Biophys. Res. Commun. 222 (1): 164–70. doi:10.1006/bbrc.1996.0700. PMID 8630063.
  3. 1 2 "Entrez Gene: BATF basic leucine zipper transcription factor, ATF-like".
  4. ↑ Schraml BU, Hildner K, Ise W, Lee WL, Smith WA, Solomon B, Sahota G, Sim J, Mukasa R, Cemerski S, Hatton RD, Stormo GD, Weaver CT, Russell JH, Murphy TL, Murphy KM (July 2009). "The AP-1 transcription factor Batf controls TH17 differentiation". Nature 460 (7253): 405–9. doi:10.1038/nature08114. PMC 2716014. PMID 19578362. Lay summary – eurekalert.org (2009-07-16).
  5. ↑ Wang X, Johansen LM, Tae HJ, Taparowsky EJ (1996). "IFP 35 forms complexes with B-ATF, a member of the AP1 family of transcription factors". Biochem. Biophys. Res. Commun. 229 (1): 316–22. doi:10.1006/bbrc.1996.1799. PMID 8954125.

Further reading

  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  • Deppmann CD, Thornton TM, Utama FE, Taparowsky EJ (2003). "Phosphorylation of BATF regulates DNA binding: a novel mechanism for AP-1 (activator protein-1) regulation". Biochem. J. 374 (Pt 2): 423–31. doi:10.1042/BJ20030455. PMC 1223616. PMID 12809553. 
  • Johansen LM, Deppmann CD, Erickson KD, Coffin WF, Thornton TM, Humphrey SE, Martin JM, Taparowsky EJ (2003). "EBNA2 and Activated Notch Induce Expression of BATF". J. Virol. 77 (10): 6029–40. doi:10.1128/JVI.77.10.6029-6040.2003. PMC 154003. PMID 12719594. 
  • Williams KL, Zullo AJ, Kaplan MH, Brutkiewicz RR, Deppmann CD, Vinson C, Taparowsky EJ (2003). "BATF transgenic mice reveal a role for activator protein-1 in NKT cell development". J. Immunol. 170 (5): 2417–26. doi:10.4049/jimmunol.170.5.2417. PMID 12594265. 
  • Echlin DR, Tae HJ, Mitin N, Taparowsky EJ (2000). "B-ATF functions as a negative regulator of AP-1 mediated transcription and blocks cellular transformation by Ras and Fos". Oncogene 19 (14): 1752–63. doi:10.1038/sj.onc.1203491. PMID 10777209. 
  • Meyer NP, Johansen LM, Tae HJ, Budde PP, Williams KL, Taparowsky EJ (1998). "Genomic organization of human B-ATF, a target for regulation by EBV and HTLV-1". Mamm. Genome 9 (10): 849–52. doi:10.1007/s003359900881. PMID 9745044. 
  • Wang X, Johansen LM, Tae HJ, Taparowsky EJ (1997). "IFP 35 forms complexes with B-ATF, a member of the AP1 family of transcription factors". Biochem. Biophys. Res. Commun. 229 (1): 316–22. doi:10.1006/bbrc.1996.1799. PMID 8954125. 
  • Hasegawa H, Utsunomiya Y, Kishimoto K, Tange Y, Yasukawa M, Fujita S (1996). "SFA-2, a novel bZIP transcription factor induced by human T-cell leukemia virus type I, is highly expressed in mature lymphocytes". Biochem. Biophys. Res. Commun. 222 (1): 164–70. doi:10.1006/bbrc.1996.0700. PMID 8630063. 
  • Dorsey MJ, Tae HJ, Sollenberger KG, Mascarenhas NT, Johansen LM, Taparowsky EJ (1996). "B-ATF: a novel human bZIP protein that associates with members of the AP-1 transcription factor family". Oncogene 11 (11): 2255–65. PMID 8570175. 

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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