HOXD10

Homeobox D10
Identifiers
Symbols	HOXD10 ; HOX4; HOX4D; HOX4E; Hox-4.4
External IDs	OMIM: 142984 MGI: 96202 HomoloGene: 1619 GeneCards: HOXD10 Gene
Gene ontology Molecular function • chromatin binding • transcription factor activity, sequence-specific DNA binding • sequence-specific DNA binding Cellular component • nucleus Biological process • transcription, DNA-templated • single fertilization • skeletal muscle tissue development • adult locomotory behavior • anterior/posterior pattern specification • proximal/distal pattern formation • spinal cord motor neuron cell fate specification • embryonic limb morphogenesis • forelimb morphogenesis • hindlimb morphogenesis • positive regulation of transcription from RNA polymerase II promoter • embryonic skeletal system morphogenesis • peripheral nervous system neuron development • neuromuscular process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3236	15430
Ensembl	ENSG00000128710	ENSMUSG00000050368
UniProt	P28358	P28359
RefSeq (mRNA)	NM_002148	NM_013554
RefSeq (protein)	NP_002139	NP_038582
Location (UCSC)	Chr 2: 176.11 – 176.12 Mb	Chr 2: 74.69 – 74.7 Mb
PubMed search

Homeobox D10, also known as HOXD10, is a protein which in humans is encoded by the HOXD10 gene.^[1]

Function

This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox D genes located on chromosome 2. The encoded nuclear protein functions as a sequence-specific transcription factor that is expressed in the developing limb buds and is involved in differentiation and limb development.

Clinical significance

Mutations in this gene have been associated with Wilms' tumor and congenital vertical talus (also known as "rocker-bottom foot" deformity or congenital convex pes valgus) and/or a foot deformity resembling that seen in Charcot-Marie-Tooth disease.^[1]

Regulation

The HOXD10 gene is repressed by the microRNAs miR-10a and miR-10b.^[2][3][4]

See also

• Homeobox

References

1. "Entrez Gene: HOXD10 homeobox D10".
2. Lund AH (Feb 2010). "miR-10 in development and cancer". Cell Death and Differentiation 17 (2): 209–14. doi:10.1038/cdd.2009.58. PMID 19461655.
3. Ma L, Teruya-Feldstein J, Weinberg RA (Oct 2007). "Tumour invasion and metastasis initiated by microRNA-10b in breast cancer". Nature 449 (7163): 682–8. doi:10.1038/nature06174. PMID 17898713.
4. Han L, Witmer PD, Casey E, Valle D, Sukumar S (Aug 2007). "DNA methylation regulates MicroRNA expression". Cancer Biology & Therapy 6 (8): 1284–8. PMID 17660710.

Further reading

• Ma L, Teruya-Feldstein J, Weinberg RA (Oct 2007). "Tumour invasion and metastasis initiated by microRNA-10b in breast cancer". Nature 449 (7163): 682–8. doi:10.1038/nature06174. PMID 17898713.
• Tabin CJ (Oct 1992). "Why we have (only) five fingers per hand: hox genes and the evolution of paired limbs". Development 116 (2): 289–96. PMID 1363084.
• Goodman FR (Oct 2002). "Limb malformations and the human HOX genes". American Journal of Medical Genetics 112 (3): 256–65. doi:10.1002/ajmg.10776. PMID 12357469.
• Redline RW, Williams AJ, Patterson P, Collins T (Jun 1992). "Human HOX4E: a gene strongly expressed in the adult male and female urogenital tracts". Genomics 13 (2): 425–30. doi:10.1016/0888-7543(92)90263-R. PMID 1351871.
• Scott MP (Nov 1992). "Vertebrate homeobox gene nomenclature". Cell 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459.
• Zappavigna V, Renucci A, Izpisúa-Belmonte JC, Urier G, Peschle C, Duboule D (Dec 1991). "HOX4 genes encode transcription factors with potential auto- and cross-regulatory capacities". The EMBO Journal 10 (13): 4177–87. PMC 453170. PMID 1756725.
• McAlpine PJ, Shows TB (Jul 1990). "Nomenclature for human homeobox genes". Genomics 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
• Peverali FA, D'Esposito M, Acampora D, Bunone G, Negri M, Faiella A, Stornaiuolo A, Pannese M, Migliaccio E, Simeone A (Oct 1990). "Expression of HOX homeogenes in human neuroblastoma cell culture lines". Differentiation; Research in Biological Diversity 45 (1): 61–9. doi:10.1111/j.1432-0436.1990.tb00458.x. PMID 1981366.
• Acampora D, D'Esposito M, Faiella A, Pannese M, Migliaccio E, Morelli F, Stornaiuolo A, Nigro V, Simeone A, Boncinelli E (Dec 1989). "The human HOX gene family". Nucleic Acids Research 17 (24): 10385–402. doi:10.1093/nar/17.24.10385. PMC 335308. PMID 2574852.
• Boncinelli E, Acampora D, Pannese M, D'Esposito M, Somma R, Gaudino G, Stornaiuolo A, Cafiero M, Faiella A, Simeone A (1990). "Organization of human class I homeobox genes". Genome / National Research Council Canada = Génome / Conseil National De Recherches Canada 31 (2): 745–56. doi:10.1139/g89-133. PMID 2576652.
• Guazzi S, Lonigro R, Pintonello L, Boncinelli E, Di Lauro R, Mavilio F (Jul 1994). "The thyroid transcription factor-1 gene is a candidate target for regulation by Hox proteins". The EMBO Journal 13 (14): 3339–47. PMC 395231. PMID 7913891.
• Redline RW, Hudock P, MacFee M, Patterson P (Nov 1994). "Expression of AbdB-type homeobox genes in human tumors". Laboratory Investigation; A Journal of Technical Methods and Pathology 71 (5): 663–70. PMID 7967520.
• Wulfsberg EA, Mirkinson LJ, Meister SJ (Jun 1993). "Autosomal dominant tetramelic postaxial oligodactyly". American Journal of Medical Genetics 46 (5): 579–83. doi:10.1002/ajmg.1320460524. PMID 8100684.
• Osborne J, Hu C, Hawley C, Underwood LJ, O'Brien TJ, Baker VV (1998). "Expression of HOXD10 gene in normal endometrium and endometrial adenocarcinoma". Journal of the Society for Gynecologic Investigation 5 (5): 277–80. doi:10.1016/S1071-5576(98)00020-3. PMID 9773404.
• Del Campo M, Jones MC, Veraksa AN, Curry CJ, Jones KL, Mascarello JT, Ali-Kahn-Catts Z, Drumheller T, McGinnis W (Jul 1999). "Monodactylous limbs and abnormal genitalia are associated with hemizygosity for the human 2q31 region that includes the HOXD cluster". American Journal of Human Genetics 65 (1): 104–10. doi:10.1086/302467. PMC 1378080. PMID 10364522.
• Shanmugam K, Green NC, Rambaldi I, Saragovi HU, Featherstone MS (Nov 1999). "PBX and MEIS as non-DNA-binding partners in trimeric complexes with HOX proteins". Molecular and Cellular Biology 19 (11): 7577–88. PMC 84774. PMID 10523646.
• Limongi MZ, Pelliccia F, Gaddini L, Rocchi A (2000). "Clustering of two fragile sites and seven homeobox genes in human chromosome region 2q31-->q32.1". Cytogenetics and Cell Genetics 90 (1-2): 151–3. doi:10.1159/000015651. PMID 11060466.
• Shen WF, Krishnan K, Lawrence HJ, Largman C (Nov 2001). "The HOX homeodomain proteins block CBP histone acetyltransferase activity". Molecular and Cellular Biology 21 (21): 7509–22. doi:10.1128/MCB.21.21.7509-7522.2001. PMC 99922. PMID 11585930.
• Goodman FR, Majewski F, Collins AL, Scambler PJ (Feb 2002). "A 117-kb microdeletion removing HOXD9-HOXD13 and EVX2 causes synpolydactyly". American Journal of Human Genetics 70 (2): 547–55. doi:10.1086/338921. PMC 384929. PMID 11778160.
• Kosaki K, Kosaki R, Suzuki T, Yoshihashi H, Takahashi T, Sasaki K, Tomita M, McGinnis W, Matsuo N (Feb 2002). "Complete mutation analysis panel of the 39 human HOX genes". Teratology 65 (2): 50–62. doi:10.1002/tera.10009. PMID 11857506.

External links

• HOXD10 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.