KLF11

Kruppel-like factor 11
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1PO4​
Identifiers
Symbols	KLF11 ; FKLF; FKLF1; MODY7; TIEG2; Tieg3
External IDs	OMIM: 603301 MGI: 2653368 HomoloGene: 2668 GeneCards: KLF11 Gene
Gene ontology Molecular function • RNA polymerase II transcription factor activity, sequence-specific DNA binding • transcription factor activity, sequence-specific DNA binding • protein binding • transcription regulatory region DNA binding • metal ion binding Cellular component • nucleus Biological process • regulation of transcription involved in G1/S transition of mitotic cell cycle • negative regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • apoptotic process • negative regulation of cell proliferation • positive regulation of apoptotic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8462	194655
Ensembl	ENSG00000172059	ENSMUSG00000020653
UniProt	O14901	Q8K1S5
RefSeq (mRNA)	NM_001177716	NM_178357
RefSeq (protein)	NP_001171187	NP_848134
Location (UCSC)	Chr 2: 10.04 – 10.05 Mb	Chr 12: 24.65 – 24.66 Mb
PubMed search

Krueppel-like factor 11 is a protein that in humans is encoded by the KLF11 gene.^[1][2][3]

Interactions

KLF11 has been shown to interact with SIN3A.^[4][5]

See also

• Kruppel-like factors
• Maturity onset diabetes of the young

References

1. Cook T, Gebelein B, Mesa K, Mladek A, Urrutia R (Oct 1998). "Molecular cloning and characterization of TIEG2 reveals a new subfamily of transforming growth factor-beta-inducible Sp1-like zinc finger-encoding genes involved in the regulation of cell growth". The Journal of Biological Chemistry 273 (40): 25929–36. doi:10.1074/jbc.273.40.25929. PMID 9748269.
2. Scohy S, Gabant P, Van Reeth T, Hertveldt V, Drèze PL, Van Vooren P, Rivière M, Szpirer J, Szpirer C (Nov 2000). "Identification of KLF13 and KLF14 (SP6), novel members of the SP/XKLF transcription factor family". Genomics 70 (1): 93–101. doi:10.1006/geno.2000.6362. PMID 11087666.
3. "Entrez Gene: KLF11 Kruppel-like factor 11".
4. Zhang JS, Moncrieffe MC, Kaczynski J, Ellenrieder V, Prendergast FG, Urrutia R (Aug 2001). "A conserved alpha-helical motif mediates the interaction of Sp1-like transcriptional repressors with the corepressor mSin3A". Molecular and Cellular Biology 21 (15): 5041–9. doi:10.1128/MCB.21.15.5041-5049.2001. PMC 87230. PMID 11438660.
5. Ellenrieder V, Zhang JS, Kaczynski J, Urrutia R (May 2002). "Signaling disrupts mSin3A binding to the Mad1-like Sin3-interacting domain of TIEG2, an Sp1-like repressor". The EMBO Journal 21 (10): 2451–60. doi:10.1093/emboj/21.10.2451. PMC 126002. PMID 12006497.

Further reading

• Asano H, Li XS, Stamatoyannopoulos G (May 1999). "FKLF, a novel Krüppel-like factor that activates human embryonic and fetal beta-like globin genes". Molecular and Cellular Biology 19 (5): 3571–9. PMC 84149. PMID 10207080.
• Zhang JS, Moncrieffe MC, Kaczynski J, Ellenrieder V, Prendergast FG, Urrutia R (Aug 2001). "A conserved alpha-helical motif mediates the interaction of Sp1-like transcriptional repressors with the corepressor mSin3A". Molecular and Cellular Biology 21 (15): 5041–9. doi:10.1128/MCB.21.15.5041-5049.2001. PMC 87230. PMID 11438660.
• Jia L, Young MF, Powell J, Yang L, Ho NC, Hotchkiss R, Robey PG, Francomano CA (Jan 2002). "Gene expression profile of human bone marrow stromal cells: high-throughput expressed sequence tag sequencing analysis". Genomics 79 (1): 7–17. doi:10.1006/geno.2001.6683. PMID 11827452.
• Ellenrieder V, Zhang JS, Kaczynski J, Urrutia R (May 2002). "Signaling disrupts mSin3A binding to the Mad1-like Sin3-interacting domain of TIEG2, an Sp1-like repressor". The EMBO Journal 21 (10): 2451–60. doi:10.1093/emboj/21.10.2451. PMC 126002. PMID 12006497.
• Ou XM, Chen K, Shih JC (May 2004). "Dual functions of transcription factors, transforming growth factor-beta-inducible early gene (TIEG)2 and Sp3, are mediated by CACCC element and Sp1 sites of human monoamine oxidase (MAO) B gene". The Journal of Biological Chemistry 279 (20): 21021–8. doi:10.1074/jbc.M312638200. PMID 15024015.
• Ellenrieder V, Buck A, Harth A, Jungert K, Buchholz M, Adler G, Urrutia R, Gress TM (Aug 2004). "KLF11 mediates a critical mechanism in TGF-beta signaling that is inactivated by Erk-MAPK in pancreatic cancer cells". Gastroenterology 127 (2): 607–20. doi:10.1053/j.gastro.2004.05.018. PMID 15300592.
• Cao S, Fernandez-Zapico ME, Jin D, Puri V, Cook TA, Lerman LO, Zhu XY, Urrutia R, Shah V (Jan 2005). "KLF11-mediated repression antagonizes Sp1/sterol-responsive element-binding protein-induced transcriptional activation of caveolin-1 in response to cholesterol signaling". The Journal of Biological Chemistry 280 (3): 1901–10. doi:10.1074/jbc.M407941200. PMID 15531587.
• Neve B, Fernandez-Zapico ME, Ashkenazi-Katalan V, Dina C, Hamid YH, Joly E, Vaillant E, Benmezroua Y, Durand E, Bakaher N, Delannoy V, Vaxillaire M, Cook T, Dallinga-Thie GM, Jansen H, Charles MA, Clément K, Galan P, Hercberg S, Helbecque N, Charpentier G, Prentki M, Hansen T, Pedersen O, Urrutia R, Melloul D, Froguel P (Mar 2005). "Role of transcription factor KLF11 and its diabetes-associated gene variants in pancreatic beta cell function". Proceedings of the National Academy of Sciences of the United States of America 102 (13): 4807–12. doi:10.1073/pnas.0409177102. PMC 554843. PMID 15774581.
• Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (May 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
• Buck A, Buchholz M, Wagner M, Adler G, Gress T, Ellenrieder V (Nov 2006). "The tumor suppressor KLF11 mediates a novel mechanism in transforming growth factor beta-induced growth inhibition that is inactivated in pancreatic cancer". Molecular Cancer Research 4 (11): 861–72. doi:10.1158/1541-7786.MCR-06-0081. PMID 17114344.
• Florez JC, Saxena R, Winckler W, Burtt NP, Almgren P, Bengtsson Boström K, Tuomi T, Gaudet D, Ardlie KG, Daly MJ, Altshuler D, Hirschhorn JN, Groop L (Dec 2006). "The Krüppel-like factor 11 (KLF11) Q62R polymorphism is not associated with type 2 diabetes in 8,676 people". Diabetes 55 (12): 3620–4. doi:10.2337/db06-0867. PMID 17130512.
• Spittau B, Wang Z, Boinska D, Krieglstein K (Jun 2007). "Functional domains of the TGF-beta-inducible transcription factor Tieg3 and detection of two putative nuclear localization signals within the zinc finger DNA-binding domain". Journal of Cellular Biochemistry 101 (3): 712–22. doi:10.1002/jcb.21228. PMID 17252542.
• Niu X, Perakakis N, Laubner K, Limbert C, Stahl T, Brendel MD, Bretzel RG, Seufert J, Päth G (Jul 2007). "Human Krüppel-like factor 11 inhibits human proinsulin promoter activity in pancreatic beta cells". Diabetologia 50 (7): 1433–41. doi:10.1007/s00125-007-0667-3. PMID 17479246.

External links

• KLF11 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.