Sp8 transcription factor
| Sp8 transcription factor | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | SP8 ; BTD | ||||||||||||
| External IDs | OMIM: 608306 MGI: 2443471 HomoloGene: 18548 GeneCards: SP8 Gene | ||||||||||||
| |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 221833 | 320145 | |||||||||||
| Ensembl | ENSG00000164651 | ENSMUSG00000048562 | |||||||||||
| UniProt | Q8IXZ3 | Q8BMJ8 | |||||||||||
| RefSeq (mRNA) | NM_182700 | NM_177082 | |||||||||||
| RefSeq (protein) | NP_874359 | NP_796056 | |||||||||||
| Location (UCSC) |
Chr 7: 20.78 – 20.79 Mb |
Chr 12: 118.85 – 118.85 Mb | |||||||||||
| PubMed search | |||||||||||||
Transcription factor Sp8 also known as specificity protein 8 (SP-8) or Btd transcription factor (buttonhead)[1] is a protein that in humans is encoded by the SP8 gene.[2][3] Sp8 is a transcription factor in the Sp/KLF family.
Function
Sp8 mediates limb outgrowth during early development.[1] Sp8 deletion in mice resulted in severe exencephaly.[4]
References
- 1 2 Treichel D, Schöck F, Jäckle H, Gruss P, Mansouri A (November 2003). "mBtd is required to maintain signaling during murine limb development". Genes Dev. 17 (21): 2630–5. doi:10.1101/gad.274103. PMC 280612. PMID 14597661.
- ↑ Bell SM, Schreiner CM, Waclaw RR, Campbell K, Potter SS, Scott WJ (October 2003). "Sp8 is crucial for limb outgrowth and neuropore closure". Proc. Natl. Acad. Sci. U.S.A. 100 (21): 12195–200. doi:10.1073/pnas.2134310100. PMC 218735. PMID 14526104.
- ↑ "Entrez Gene: Sp8 transcription factor".
- ↑ Waclaw RR, Allen ZJ, Bell SM, Erdélyi F, Szabó G, Potter SS, Campbell K (February 2006). "The zinc finger transcription factor Sp8 regulates the generation and diversity of olfactory bulb interneurons". Neuron 49 (4): 503–16. doi:10.1016/j.neuron.2006.01.018. PMID 16476661.
Further reading
- Lee MT, Chen CH, Lee CS, et al. (2011). "Genome-wide association study of bipolar I disorder in the Han Chinese population.". Mol. Psychiatry 16 (5): 548–56. doi:10.1038/mp.2010.43. PMID 20386566.
- Milona MA, Gough JE, Edgar AJ (2004). "Genomic structure and cloning of two transcript isoforms of human Sp8.". BMC Genomics 5: 86. doi:10.1186/1471-2164-5-86. PMC 534095. PMID 15533246.
- Jugessur A, Shi M, Gjessing HK, et al. (2010). "Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.". PLoS ONE 5 (7): e11493. doi:10.1371/journal.pone.0011493. PMC 2901336. PMID 20634891.
- Barber MJ, Mangravite LM, Hyde CL, et al. (2010). "Genome-wide association of lipid-lowering response to statins in combined study populations.". PLoS ONE 5 (3): e9763. doi:10.1371/journal.pone.0009763. PMC 2842298. PMID 20339536.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Ravasi T, Suzuki H, Cannistraci CV, et al. (2010). "An atlas of combinatorial transcriptional regulation in mouse and man.". Cell 140 (5): 744–52. doi:10.1016/j.cell.2010.01.044. PMC 2836267. PMID 20211142.
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