POU3F2

POU class 3 homeobox 2
Identifiers
Symbols	POU3F2 ; BRN2; N-Oct3; OCT7; OTF-7; OTF7; POUF3; brn-2; oct-7
External IDs	OMIM: 600494 MGI: 101895 HomoloGene: 4095 ChEMBL: 4189 GeneCards: POU3F2 Gene
Gene ontology Molecular function • RNA polymerase II core promoter proximal region sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • RNA polymerase II transcription coactivator activity • transcription factor activity, sequence-specific DNA binding • protein binding • identical protein binding Cellular component • nucleus • transcription factor complex Biological process • transcription from RNA polymerase II promoter • positive regulation of cell proliferation • epidermis development • negative regulation of gene expression • astrocyte development • cerebral cortex radially oriented cell migration • forebrain ventricular zone progenitor cell division • hypothalamus cell differentiation • neurohypophysis development • myelination in peripheral nervous system • neuron differentiation • positive regulation of multicellular organism growth • positive regulation of transcription from RNA polymerase II promoter • regulation of axonogenesis • cellular response to organic substance Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5454	18992
Ensembl	ENSG00000184486	ENSMUSG00000095139
UniProt	P20265	P31360
RefSeq (mRNA)	NM_005604	NM_008899
RefSeq (protein)	NP_005595	NP_032925
Location (UCSC)	Chr 6: 98.83 – 98.84 Mb	Chr 4: 22.48 – 22.49 Mb
PubMed search

POU domain, class 3, transcription factor 2 is a protein that in humans is encoded by the POU3F2 gene.^[1][2]

Function

N-Oct-3 is a protein belonging to a large family of transcription factors that bind to the octameric DNA sequence ATGCAAAT. Most of these proteins share a highly homologous region, referred to as the POU domain, which occurs in several mammalian transcription factors, including the octamer-binding proteins Oct1 (POU2F1; MIM 164175) and Oct2 (POU2F2; MIM 164176), and the pituitary protein Pit1 (PIT1; MIM 173110). Class III POU genes are expressed predominantly in the CNS. It is likely that CNS-specific transcription factors such as these play an important role in mammalian neurogenesis by regulating their diverse patterns of gene expression.[supplied by OMIM]^[2]

Disease Linkage

The POU3F2 protein associates with the Bipolar disorder. Is involved in the neocortex development in mice, and is linked to a single nucletide polymorphism, Rs1906252, that is associated with a cognitive phenotype: processing information speed.^[3]

Interactions

POU3F2 has been shown to interact with PQBP1.^[4]

See also

• Octamer transcription factor

References

1. Schreiber E, Tobler A, Malipiero U, Schaffner W, Fontana A (Mar 1993). "cDNA cloning of human N-Oct3, a nervous-system specific POU domain transcription factor binding to the octamer DNA motif". Nucleic Acids Res 21 (2): 253–8. doi:10.1093/nar/21.2.253. PMC 309100. PMID 8441633.
2. "Entrez Gene: POU3F2 POU domain, class 3, transcription factor 2".
3. "Genome-wide association study reveals two new risk loci for bipolar disorder".
4. Waragai M, Lammers CH, Takeuchi S, Imafuku I, Udagawa Y, Kanazawa I, Kawabata M, Mouradian MM, Okazawa H (Jun 1999). "PQBP-1, a novel polyglutamine tract-binding protein, inhibits transcription activation by Brn-2 and affects cell survival". Hum. Mol. Genet. 8 (6): 977–87. doi:10.1093/hmg/8.6.977. PMID 10332029.

Further reading

• Hara Y, Rovescalli AC, Kim Y, Nirenberg M (1992). "Structure and evolution of four POU domain genes expressed in mouse brain.". Proc. Natl. Acad. Sci. U.S.A. 89 (8): 3280–4. doi:10.1073/pnas.89.8.3280. PMC 48850. PMID 1565620.
• Schreiber E, Harshman K, Kemler I, Malipiero U, Schaffner W, Fontana A (1990). "Astrocytes and glioblastoma cells express novel octamer-DNA binding proteins distinct from the ubiquitous Oct-1 and B cell type Oct-2 proteins.". Nucleic Acids Res. 18 (18): 5495–503. doi:10.1093/nar/18.18.5495. PMC 332229. PMID 2216722.
• He X, Treacy MN, Simmons DM, Ingraham HA, Swanson LW, Rosenfeld MG (1989). "Expression of a large family of POU-domain regulatory genes in mammalian brain development.". Nature 340 (6228): 35–41. doi:10.1038/340035a0. PMID 2739723.
• Eisen T, Easty DJ, Bennett DC, Goding CR (1995). "The POU domain transcription factor Brn-2: elevated expression in malignant melanoma and regulation of melanocyte-specific gene expression.". Oncogene 11 (10): 2157–64. PMID 7478537.
• Atanasoski S, Toldo SS, Malipiero U, Schreiber E, Fries R, Fontana A (1995). "Isolation of the human genomic brain-2/N-Oct 3 gene (POUF3) and assignment to chromosome 6q16.". Genomics 26 (2): 272–80. doi:10.1016/0888-7543(95)80211-4. PMID 7601453.
• Thomson JA, Murphy K, Baker E, Sutherland GR, Parsons PG, Sturm RA, Thomson F (1995). "The brn-2 gene regulates the melanocytic phenotype and tumorigenic potential of human melanoma cells.". Oncogene 11 (4): 691–700. PMID 7651733.
• Atanasoski S, Schreiber E, Fontana A, Herr W (1997). "N-Oct 5 is generated by in vitro proteolysis of the neural POU-domain protein N-Oct 3.". Oncogene 14 (11): 1287–94. doi:10.1038/sj.onc.1200953. PMID 9178889.
• Petersenn S, Rasch AC, Heyens M, Schulte HM (1998). "Structure and regulation of the human growth hormone-releasing hormone receptor gene.". Mol. Endocrinol. 12 (2): 233–47. doi:10.1210/me.12.2.233. PMID 9482665.
• Kuhlbrodt K, Herbarth B, Sock E, Enderich J, Hermans-Borgmeyer I, Wegner M (1998). "Cooperative function of POU proteins and SOX proteins in glial cells.". J. Biol. Chem. 273 (26): 16050–7. doi:10.1074/jbc.273.26.16050. PMID 9632656.
• Waragai M, Lammers CH, Takeuchi S, Imafuku I, Udagawa Y, Kanazawa I, Kawabata M, Mouradian MM, Okazawa H (1999). "PQBP-1, a novel polyglutamine tract-binding protein, inhibits transcription activation by Brn-2 and affects cell survival.". Hum. Mol. Genet. 8 (6): 977–87. doi:10.1093/hmg/8.6.977. PMID 10332029.
• Smit DJ, Smith AG, Parsons PG, Muscat GE, Sturm RA (2000). "Domains of Brn-2 that mediate homodimerization and interaction with general and melanocytic transcription factors.". Eur. J. Biochem. 267 (21): 6413–22. doi:10.1046/j.1432-1327.2000.01737.x. PMID 11029584.
• Jaegle M, Ghazvini M, Mandemakers W, Piirsoo M, Driegen S, Levavasseur F, Raghoenath S, Grosveld F, Meijer D (2003). "The POU proteins Brn-2 and Oct-6 share important functions in Schwann cell development.". Genes Dev. 17 (11): 1380–91. doi:10.1101/gad.258203. PMC 196070. PMID 12782656.
• Goodall J, Martinozzi S, Dexter TJ, Champeval D, Carreira S, Larue L, Goding CR (2004). "Brn-2 expression controls melanoma proliferation and is directly regulated by beta-catenin.". Mol. Cell. Biol. 24 (7): 2915–22. doi:10.1128/MCB.24.7.2915-2922.2004. PMC 371132. PMID 15024079.
• Goodall J, Wellbrock C, Dexter TJ, Roberts K, Marais R, Goding CR (2004). "The Brn-2 transcription factor links activated BRAF to melanoma proliferation.". Mol. Cell. Biol. 24 (7): 2923–31. doi:10.1128/MCB.24.7.2923-2931.2004. PMC 371133. PMID 15024080.
• Cobrinik D, Francis RO, Abramson DH, Lee TC (2007). "Rb induces a proliferative arrest and curtails Brn-2 expression in retinoblastoma cells.". Mol. Cancer 5 (1): 72. doi:10.1186/1476-4598-5-72. PMC 1764425. PMID 17163992.

External links

• POU3F2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.