Rev-ErbA

nuclear receptor subfamily 1, group D, member 1
Identifiers
Symbol	NR1D1
Alt. symbols	ear-1, hRev, Rev-ErbAalpha, THRA1
Entrez	9572
HUGO	7962
OMIM	602408
RefSeq	NM_021724
UniProt	P20393
Other data
Locus	Chr. 17 q11.2

nuclear receptor subfamily 1, group D, member 2
Identifiers
Symbol	NR1D2
Alt. symbols	BD73, RVR, EAR-1r, HZF2, Hs.37288
Entrez	9975
HUGO	7963
OMIM	602304
RefSeq	XM_001130839
UniProt	Q14995
Other data
Locus	Chr. 3 p24.1

The Rev-ErbA proteins are members of the nuclear receptor family of intracellular transcription factors. There are two forms of the receptor, alpha and beta, each encoded by a separate gene (NR1D1 and NR1D2 respectively).^[1][2]

The rev-Erb-α gene is highly unusual in that it is encoded on the opposite strand of the alpha-thyroid hormone receptor (TR) gene.^[1]

The rev-Erb-α protein is a key regulatory component of the circadian clock.^[3][4] In addition, rev-Erb-α appears also to regulate the breakdown of cartilage.^[5]

References

1. Lazar MA, Jones KE, Chin WW (1990). "Isolation of a cDNA encoding human Rev-ErbA alpha: transcription from the noncoding DNA strand of a thyroid hormone receptor gene results in a related protein that does not bind thyroid hormone". DNA Cell Biol. 9 (2): 77–83. doi:10.1089/dna.1990.9.77. PMID 1971514.
2. Dumas B, Harding HP, Choi HS, Lehmann KA, Chung M, Lazar MA, Moore DD (1994). "A new orphan member of the nuclear hormone receptor superfamily closely related to Rev-Erb". Mol. Endocrinol. 8 (8): 996–1005. doi:10.1210/me.8.8.996. PMID 7997240.
3. Yin L, Wang J, Klein PS, Lazar MA (2006). "Nuclear receptor Rev-erbalpha is a critical lithium-sensitive component of the circadian clock". Science 311 (5763): 1002–5. doi:10.1126/science.1121613. PMID 16484495.
4. Wang J, Yin L, Lazar MA (2006). "The orphan nuclear receptor Rev-erb alpha regulates circadian expression of plasminogen activator inhibitor type 1". J. Biol. Chem. 281 (45): 33842–8. doi:10.1074/jbc.M607873200. PMID 16968709.
5. Chaturvedi P, Pratta M, Steplewski K, Connor J, Kumar S (2006). "Functional characterization of an orphan nuclear receptor, Rev-ErbAalpha, in chondrocytes and its potential role in osteoarthritis". Arthritis Rheum. 54 (11): 3513–22. doi:10.1002/art.22170. PMID 17075855.

External links

• HZF-2alpha at the US National Library of Medicine Medical Subject Headings (MeSH)
• HZF-2beta at the US National Library of Medicine Medical Subject Headings (MeSH)
• NR1D1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)