KLF6
Krueppel-like factor 6 is a protein that in humans is encoded by the KLF6 gene.[1]
It is a tumor suppressor gene.[2]
Function
This gene encodes a nuclear protein that has three zinc fingers at the end of its C-terminal domain, a serine/threonine-rich central region, and an acidic domain lying within the N-terminal region. The zinc fingers of this protein are responsible for the specific DNA binding with the guanine-rich core promoter elements. The central region might be involved in activation or posttranslational regulatory pathways, and the acidic N-terminal domain might play an important role in the process of transcriptional activation. It is capable of activating transcription approximately 4-fold either on homologous or heterologous promoters. The DNA binding and transcriptional activity of this protein, in conjunction with its expression pattern, suggests that this protein may participate in the regulation and/or maintenance of the basal expression of pregnancy-specific glycoprotein genes and possibly other TATA box-less genes. Two transcript variants encoding the same protein have been found for this gene.[3]
Interactions
KLF6 has been shown to interact with Sp1 transcription factor.[4]
See also
References
- ↑ Onyango P, Koritschoner NP, Patrito LC, Zenke M, Weith A (Feb 1998). "Assignment of the gene encoding the core promoter element binding protein (COPEB) to human chromosome 10p15 by somatic hybrid analysis and fluorescence in situ hybridization". Genomics 48 (1): 143–4. doi:10.1006/geno.1997.5124. PMID 9503030.
- ↑ Li D, Yea S, Dolios G, Martignetti JA, Narla G, Wang R, Walsh MJ, Friedman SL (Oct 2005). "Regulation of Kruppel-like factor 6 tumor suppressor activity by acetylation". Cancer Research 65 (20): 9216–25. doi:10.1158/0008-5472.CAN-05-1040. PMID 16230382.
- ↑ "Entrez Gene: KLF6 Kruppel-like factor 6".
- ↑ Botella LM, Sánchez-Elsner T, Sanz-Rodriguez F, Kojima S, Shimada J, Guerrero-Esteo M, Cooreman MP, Ratziu V, Langa C, Vary CP, Ramirez JR, Friedman S, Bernabéu C (Dec 2002). "Transcriptional activation of endoglin and transforming growth factor-beta signaling components by cooperative interaction between Sp1 and KLF6: their potential role in the response to vascular injury". Blood 100 (12): 4001–10. doi:10.1182/blood.V100.12.4001. PMID 12433697.
Further reading
- Narla G, Friedman SL, Martignetti JA (Apr 2003). "Krüppel cripples prostate cancer: KLF6 progress and prospects". The American Journal of Pathology 162 (4): 1047–52. doi:10.1016/S0002-9440(10)63901-6. PMC 1851219. PMID 12651597.
- El Rouby S, Newcomb EW (Dec 1996). "Identification of Bcd, a novel proto-oncogene expressed in B-cells". Oncogene 13 (12): 2623–30. PMID 9000136.
- Koritschoner NP, Bocco JL, Panzetta-Dutari GM, Dumur CI, Flury A, Patrito LC (Apr 1997). "A novel human zinc finger protein that interacts with the core promoter element of a TATA box-less gene". The Journal of Biological Chemistry 272 (14): 9573–80. doi:10.1074/jbc.272.14.9573. PMID 9083102.
- Suzuki T, Yamamoto T, Kurabayashi M, Nagai R, Yazaki Y, Horikoshi M (Aug 1998). "Isolation and initial characterization of GBF, a novel DNA-binding zinc finger protein that binds to the GC-rich binding sites of the HIV-1 promoter". Journal of Biochemistry 124 (2): 389–95. doi:10.1093/oxfordjournals.jbchem.a022124. PMID 9685731.
- Ratziu V, Lalazar A, Wong L, Dang Q, Collins C, Shaulian E, Jensen S, Friedman SL (Aug 1998). "Zf9, a Kruppel-like transcription factor up-regulated in vivo during early hepatic fibrosis". Proceedings of the National Academy of Sciences of the United States of America 95 (16): 9500–5. doi:10.1073/pnas.95.16.9500. PMC 21367. PMID 9689109.
- Okano J, Opitz OG, Nakagawa H, Jenkins TD, Friedman SL, Rustgi AK (May 2000). "The Krüppel-like transcriptional factors Zf9 and GKLF coactivate the human keratin 4 promoter and physically interact". FEBS Letters 473 (1): 95–100. doi:10.1016/S0014-5793(00)01468-X. PMID 10802067.
- Narla G, Heath KE, Reeves HL, Li D, Giono LE, Kimmelman AC, Glucksman MJ, Narla J, Eng FJ, Chan AM, Ferrari AC, Martignetti JA, Friedman SL (Dec 2001). "KLF6, a candidate tumor suppressor gene mutated in prostate cancer". Science 294 (5551): 2563–6. doi:10.1126/science.1066326. PMID 11752579.
- Botella LM, Sánchez-Elsner T, Sanz-Rodriguez F, Kojima S, Shimada J, Guerrero-Esteo M, Cooreman MP, Ratziu V, Langa C, Vary CP, Ramirez JR, Friedman S, Bernabéu C (Dec 2002). "Transcriptional activation of endoglin and transforming growth factor-beta signaling components by cooperative interaction between Sp1 and KLF6: their potential role in the response to vascular injury". Blood 100 (12): 4001–10. doi:10.1182/blood.V100.12.4001. PMID 12433697.
- Chen HK, Liu XQ, Lin J, Chen TY, Feng QS, Zeng YX (Oct 2002). "[Mutation analysis of KLF6 gene in human nasopharyngeal carcinomas]". Ai Zheng = Aizheng = Chinese Journal of Cancer 21 (10): 1047–50. PMID 12508640.
- Warke VG, Nambiar MP, Krishnan S, Tenbrock K, Geller DA, Koritschoner NP, Atkins JL, Farber DL, Tsokos GC (Apr 2003). "Transcriptional activation of the human inducible nitric-oxide synthase promoter by Kruppel-like factor 6". The Journal of Biological Chemistry 278 (17): 14812–9. doi:10.1074/jbc.M300787200. PMID 12590140.
- Chen C, Hyytinen ER, Sun X, Helin HJ, Koivisto PA, Frierson HF, Vessella RL, Dong JT (Apr 2003). "Deletion, mutation, and loss of expression of KLF6 in human prostate cancer". The American Journal of Pathology 162 (4): 1349–54. doi:10.1016/S0002-9440(10)63930-2. PMC 1851229. PMID 12651626.
- Jeng YM, Hsu HC (Jul 2003). "KLF6, a putative tumor suppressor gene, is mutated in astrocytic gliomas". International Journal of Cancer. Journal International Du Cancer 105 (5): 625–9. doi:10.1002/ijc.11123. PMID 12740910.
- Bayat A, Watson JS, Stanley JK, Ferguson MW, Ollier WE (Jun 2003). "Genetic susceptibility to dupuytren disease: association of Zf9 transcription factor gene". Plastic and Reconstructive Surgery 111 (7): 2133–9. doi:10.1097/01.PRS.0000060531.98180.32. PMID 12794452.
- Reeves HL, Narla G, Ogunbiyi O, Haq AI, Katz A, Benzeno S, Hod E, Harpaz N, Goldberg S, Tal-Kremer S, Eng FJ, Arthur MJ, Martignetti JA, Friedman SL (Apr 2004). "Kruppel-like factor 6 (KLF6) is a tumor-suppressor gene frequently inactivated in colorectal cancer". Gastroenterology 126 (4): 1090–103. doi:10.1053/j.gastro.2004.01.005. PMID 15057748.
- Kimmelman AC, Qiao RF, Narla G, Banno A, Lau N, Bos PD, Nuñez Rodriguez N, Liang BC, Guha A, Martignetti JA, Friedman SL, Chan AM (Jun 2004). "Suppression of glioblastoma tumorigenicity by the Kruppel-like transcription factor KLF6". Oncogene 23 (29): 5077–83. doi:10.1038/sj.onc.1207662. PMID 15064720.
- Glinsky GV, Glinskii AB, Stephenson AJ, Hoffman RM, Gerald WL (Mar 2004). "Gene expression profiling predicts clinical outcome of prostate cancer". The Journal of Clinical Investigation 113 (6): 913–23. doi:10.1172/JCI20032. PMC 362118. PMID 15067324.
- Rubinstein M, Idelman G, Plymate SR, Narla G, Friedman SL, Werner H (Aug 2004). "Transcriptional activation of the insulin-like growth factor I receptor gene by the Kruppel-like factor 6 (KLF6) tumor suppressor protein: potential interactions between KLF6 and p53". Endocrinology 145 (8): 3769–77. doi:10.1210/en.2004-0173. PMID 15131018.
External links
- KLF6 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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