Testicular receptor 4

Nuclear receptor subfamily 2, group C, member 2
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3P0U​
Identifiers
Symbols	NR2C2 ; TAK1; TR4
External IDs	OMIM: 601426 MGI: 1352466 HomoloGene: 2475 IUPHAR: 614 ChEMBL: 5716 GeneCards: NR2C2 Gene
Gene ontology Molecular function • transcription factor activity, sequence-specific DNA binding • steroid hormone receptor activity • transcription coactivator activity • receptor activity • protein binding • zinc ion binding • sequence-specific DNA binding • protein heterodimerization activity Cellular component • nucleoplasm Biological process • regulation of transcription, DNA-templated • transcription initiation from RNA polymerase II promoter • spermatogenesis • nervous system development • gene expression • cerebellum development • cell differentiation • p38MAPK cascade • positive regulation of embryonic development • steroid hormone mediated signaling pathway • positive regulation of myoblast differentiation • positive regulation of transcription from RNA polymerase II promoter • positive regulation of behavior • meiotic cell cycle • activation of mitophagy in response to mitochondrial depolarization Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7182	22026
Ensembl	ENSG00000177463	ENSMUSG00000005893
UniProt	P49116	P49117
RefSeq (mRNA)	NM_001291694	NM_011630
RefSeq (protein)	NP_001278623	NP_035760
Location (UCSC)	Chr 3: 14.95 – 15.05 Mb	Chr 6: 92.09 – 92.17 Mb
PubMed search

Testicular receptor 4 also known as NR2C2 (nuclear receptor subfamily 2, group C, member 2) is a protein that in humans is encoded by the NR2C2 gene.^[1][2][3]

The testicular receptor 4 is a member of the nuclear receptor family of transcription factors.

Interactions

Testicular receptor 4 has been shown to interact with

• Androgen receptor,^[4]
• Estrogen receptor alpha,^[5] and
• Hepatocyte nuclear factor 4 alpha.^[6]

See also

• Testicular receptor

References

1. "Entrez Gene: NR2C2".
2. Chang C, Da Silva SL, Ideta R, Lee Y, Yeh S, Burbach JP (Jun 1994). "Human and rat TR4 orphan receptors specify a subclass of the steroid receptor superfamily". Proceedings of the National Academy of Sciences of the United States of America 91 (13): 6040–4. doi:10.1073/pnas.91.13.6040. PMC 44133. PMID 8016112.
3. Yoshikawa T, DuPont BR, Leach RJ, Detera-Wadleigh SD (Jul 1996). "New variants of the human and rat nuclear hormone receptor, TR4: expression and chromosomal localization of the human gene". Genomics 35 (2): 361–6. doi:10.1006/geno.1996.0368. PMID 8661150.
4. Lee YF, Shyr CR, Thin TH, Lin WJ, Chang C (Dec 1999). "Convergence of two repressors through heterodimer formation of androgen receptor and testicular orphan receptor-4: a unique signaling pathway in the steroid receptor superfamily". Proceedings of the National Academy of Sciences of the United States of America 96 (26): 14724–9. doi:10.1073/pnas.96.26.14724. PMC 24715. PMID 10611280.
5. Shyr CR, Hu YC, Kim E, Chang C (Apr 2002). "Modulation of estrogen receptor-mediated transactivation by orphan receptor TR4 in MCF-7 cells". The Journal of Biological Chemistry 277 (17): 14622–8. doi:10.1074/jbc.M110051200. PMID 11844790.
6. Lin WJ, Li J, Lee YF, Yeh SD, Altuwaijri S, Ou JH, Chang C (Mar 2003). "Suppression of hepatitis B virus core promoter by the nuclear orphan receptor TR4". The Journal of Biological Chemistry 278 (11): 9353–60. doi:10.1074/jbc.M205944200. PMID 12522137.

Further reading

• Hirose T, Fujimoto W, Tamaai T, Kim KH, Matsuura H, Jetten AM (Dec 1994). "TAK1: molecular cloning and characterization of a new member of the nuclear receptor superfamily". Molecular Endocrinology 8 (12): 1667–80. doi:10.1210/me.8.12.1667. PMID 7708055.
• Young WJ, Smith SM, Chang C (Jan 1997). "Induction of the intronic enhancer of the human ciliary neurotrophic factor receptor (CNTFRalpha) gene by the TR4 orphan receptor. A member of steroid receptor superfamily". The Journal of Biological Chemistry 272 (5): 3109–16. doi:10.1074/jbc.272.5.3109. PMID 9006963.
• Lee CH, Chinpaisal C, Wei LN (Sep 1998). "A novel nuclear receptor heterodimerization pathway mediated by orphan receptors TR2 and TR4". The Journal of Biological Chemistry 273 (39): 25209–15. doi:10.1074/jbc.273.39.25209. PMID 9737983.
• Lee YF, Shyr CR, Thin TH, Lin WJ, Chang C (Dec 1999). "Convergence of two repressors through heterodimer formation of androgen receptor and testicular orphan receptor-4: a unique signaling pathway in the steroid receptor superfamily". Proceedings of the National Academy of Sciences of the United States of America 96 (26): 14724–9. doi:10.1073/pnas.96.26.14724. PMC 24715. PMID 10611280.
• Wang X, Yeh S, Wu G, Hsu CL, Wang L, Chiang T, Yang Y, Guo Y, Chang C (Nov 2001). "Identification and characterization of a novel androgen receptor coregulator ARA267-alpha in prostate cancer cells". The Journal of Biological Chemistry 276 (44): 40417–23. doi:10.1074/jbc.M104765200. PMID 11509567.
• Yeung KC, Rose DW, Dhillon AS, Yaros D, Gustafsson M, Chatterjee D, McFerran B, Wyche J, Kolch W, Sedivy JM (Nov 2001). "Raf kinase inhibitor protein interacts with NF-kappaB-inducing kinase and TAK1 and inhibits NF-kappaB activation". Molecular and Cellular Biology 21 (21): 7207–17. doi:10.1128/MCB.21.21.7207-7217.2001. PMC 99896. PMID 11585904.
• Shyr CR, Hu YC, Kim E, Chang C (Apr 2002). "Modulation of estrogen receptor-mediated transactivation by orphan receptor TR4 in MCF-7 cells". The Journal of Biological Chemistry 277 (17): 14622–8. doi:10.1074/jbc.M110051200. PMID 11844790.
• Tanabe O, Katsuoka F, Campbell AD, Song W, Yamamoto M, Tanimoto K, Engel JD (Jul 2002). "An embryonic/fetal beta-type globin gene repressor contains a nuclear receptor TR2/TR4 heterodimer". The EMBO Journal 21 (13): 3434–42. doi:10.1093/emboj/cdf340. PMC 126089. PMID 12093744.
• Yang Y, Wang X, Dong T, Kim E, Lin WJ, Chang C (Feb 2003). "Identification of a novel testicular orphan receptor-4 (TR4)-associated protein as repressor for the selective suppression of TR4-mediated transactivation". The Journal of Biological Chemistry 278 (9): 7709–17. doi:10.1074/jbc.M207116200. PMID 12486131.
• Lin WJ, Li J, Lee YF, Yeh SD, Altuwaijri S, Ou JH, Chang C (Mar 2003). "Suppression of hepatitis B virus core promoter by the nuclear orphan receptor TR4". The Journal of Biological Chemistry 278 (11): 9353–60. doi:10.1074/jbc.M205944200. PMID 12522137.
• Takaesu G, Surabhi RM, Park KJ, Ninomiya-Tsuji J, Matsumoto K, Gaynor RB (Feb 2003). "TAK1 is critical for IkappaB kinase-mediated activation of the NF-kappaB pathway". Journal of Molecular Biology 326 (1): 105–15. doi:10.1016/S0022-2836(02)01404-3. PMID 12547194.
• Inui S, Lee YF, Chang E, Shyr CR, Chang C (Feb 2003). "Differential and bi-directional regulation between TR2/TR4 orphan nuclear receptors and a specific ligand mediated-peroxisome proliferator-activated receptor alpha in human HaCaT keratinocytes". Journal of Dermatological Science 31 (1): 65–71. doi:10.1016/S0923-1811(02)00152-4. PMID 12615366.
• Ishitani T, Takaesu G, Ninomiya-Tsuji J, Shibuya H, Gaynor RB, Matsumoto K (Dec 2003). "Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling". The EMBO Journal 22 (23): 6277–88. doi:10.1093/emboj/cdg605. PMC 291846. PMID 14633987.
• Cheung PC, Nebreda AR, Cohen P (Feb 2004). "TAB3, a new binding partner of the protein kinase TAK1". The Biochemical Journal 378 (Pt 1): 27–34. doi:10.1042/BJ20031794. PMC 1223947. PMID 14670075.
• Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G (Feb 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nature Cell Biology 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.

External links

• FactorBook TR4