EHF (gene)

Ets homologous factor
Identifiers
Symbols	EHF ; ESE3; ESE3B; ESEJ
External IDs	OMIM: 605439 MGI: 1270840 HomoloGene: 7301 GeneCards: EHF Gene
Gene ontology Molecular function • RNA polymerase II core promoter proximal region sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • DNA binding • transcription factor activity, sequence-specific DNA binding Cellular component • nucleus • nucleoplasm • Golgi apparatus Biological process • transcription from RNA polymerase II promoter • multicellular organismal development • cell proliferation • epithelial cell differentiation • positive regulation of transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	26298	13661
Ensembl	ENSG00000135373	ENSMUSG00000012350
UniProt	Q9NZC4	O70273
RefSeq (mRNA)	NM_001206615	NM_007914
RefSeq (protein)	NP_001193544	NP_031940
Location (UCSC)	Chr 11: 34.62 – 34.66 Mb	Chr 2: 103.26 – 103.3 Mb
PubMed search

ETS homologous factor is a protein that in humans is encoded by the EHF gene.^[1][2] This gene encodes a protein that belongs to an ETS transcription factor subfamily characterized by epithelial-specific expression (ESEs). The encoded protein acts as a transcriptional repressor and may be associated with asthma susceptibility. This protein may be involved in epithelial differentiation and carcinogenesis.^[2]

Further reading

Cangemi, R., Mensah, A., Albertini, V., Jain, A., Mello-Grand, M., Chiorino, G., Catapano, C.V. & Carbone, G.M. Reduced expression and tumor suppressor function of the ETS transcription factor ESE-3 in prostate cancer. Oncogene 27, 2877-2885 (2008).

Albino D, Longoni N, Curti L, Mello-Grand M, Pinton S, Civenni G, Thalmann G, D'Ambrosio G, Sarti M, Sessa F, Chiorino G, Catapano CV, Carbone GM. ESE3/EHF controls epithelial cell differentiation and its loss leads to prostate tumors with mesenchymal and stem-like features. Cancer Res. 2012 Jun 1;72(11):2889-900.

Kunderfranco, P., Mello-Grand, M., Cangemi, R., Pellini, S., Mensah, A., Albertini, V., Malek, A., Chiorino, G., Catapano, C.V. & Carbone, G.M. ETS transcription factors control transcription of EZH2 and epigenetic silencing of the tumor suppressor gene Nkx3.1 in prostate cancer. PLoS One 5, e10547 (2010).

References

1. Kleinbaum LA, Duggan C, Ferreira E, Coffey GP, Buttice G, Burton FH (Nov 1999). "Human chromosomal localization, tissue/tumor expression, and regulatory function of the ets family gene EHF". Biochem Biophys Res Commun 264 (1): 119–26. doi:10.1006/bbrc.1999.1493. PMID 10527851.
2. "Entrez Gene: EHF ets homologous factor".

• Fujikawa M, Katagiri T, Tugores A; et al. (2007). "ESE-3, an Ets family transcription factor, is up-regulated in cellular senescence.". Cancer Sci. 98 (9): 1468–75. doi:10.1111/j.1349-7006.2007.00543.x. PMID 17627613.
• Ewing RM, Chu P, Elisma F; et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Park C, Lee I, Kang WK (2007). "Influence of small interfering RNA corresponding to ets homologous factor on senescence-associated modulation of prostate carcinogenesis.". Mol. Cancer Ther. 5 (12): 3191–6. doi:10.1158/1535-7163.MCT-06-0570. PMID 17172423.
• Lim JH, Cho JY, Park YB; et al. (2006). "ESE-3 transcription factor is involved in the expression of death receptor (DR)-5 through putative Ets sites.". Biochem. Biophys. Res. Commun. 350 (3): 736–41. doi:10.1016/j.bbrc.2006.09.102. PMID 17027647.
• Taylor TD, Noguchi H, Totoki Y; et al. (2006). "Human chromosome 11 DNA sequence and analysis including novel gene identification.". Nature 440 (7083): 497–500. doi:10.1038/nature04632. PMID 16554811.
• Appel S, Bringmann A, Grünebach F; et al. (2006). "Epithelial-specific transcription factor ESE-3 is involved in the development of monocyte-derived DCs.". Blood 107 (8): 3265–70. doi:10.1182/blood-2005-06-2480. PMID 16380452.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Silverman ES, Baron RM, Palmer LJ; et al. (2003). "Constitutive and cytokine-induced expression of the ETS transcription factor ESE-3 in the lung.". Am. J. Respir. Cell Mol. Biol. 27 (6): 697–704. doi:10.1165/rcmb.2002-0011oc. PMID 12444029.
• Tugores A, Le J, Sorokina I; et al. (2001). "The epithelium-specific ETS protein EHF/ESE-3 is a context-dependent transcriptional repressor downstream of MAPK signaling cascades.". J. Biol. Chem. 276 (23): 20397–406. doi:10.1074/jbc.M010930200. PMID 11259407.
• Dias Neto E, Correa RG, Verjovski-Almeida S; et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
• Kas K, Finger E, Grall F; et al. (2000). "ESE-3, a novel member of an epithelium-specific ets transcription factor subfamily, demonstrates different target gene specificity from ESE-1.". J. Biol. Chem. 275 (4): 2986–98. doi:10.1074/jbc.275.4.2986. PMID 10644770.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.

External links

• EHF protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.