CAMP responsive element modulator

CAMP responsive element modulator
PDB rendering based on 1dh3.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1dh3​
Identifiers
Symbols	CREM ; CREM-2; ICER; hCREM-2
External IDs	OMIM: 123812 HomoloGene: 84591 GeneCards: CREM Gene
Gene ontology Molecular function • core promoter sequence-specific DNA binding • DNA binding • transcription factor activity, sequence-specific DNA binding • protein binding • cAMP response element binding protein binding Cellular component • nucleus • transcription factor complex • cytoplasm Biological process • glucose metabolic process • transcription, DNA-templated • regulation of transcription, DNA-templated • fatty acid metabolic process • glycosphingolipid metabolic process • signal transduction • multicellular organismal development • spermatogenesis • cell differentiation • circadian regulation of gene expression • regulation of circadian rhythm • negative regulation of transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter • retinoic acid receptor signaling pathway • response to cAMP Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1390	12916
Ensembl	ENSG00000095794	ENSMUSG00000063889
UniProt	Q03060	P27699
RefSeq (mRNA)	NM_001267562	NM_001110850
RefSeq (protein)	NP_001254491	NP_001104320
Location (UCSC)	Chr 10: 35.13 – 35.21 Mb	Chr 18: 3.27 – 3.34 Mb
PubMed search

cAMP-responsive element modulator is a protein that in humans is encoded by the CREM gene.^[1][2][3]

Function

This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription.^[3]

Interactions

CAMP responsive element modulator has been shown to interact with FHL5.^[4][5]

References

1. Meyer TE, Habener JF (Nov 1992). "Cyclic AMP response element binding protein CREB and modulator protein CREM are products of distinct genes". Nucleic Acids Research 20 (22): 6106. doi:10.1093/nar/20.22.6106. PMC 334485. PMID 1461747.
2. Masquilier D, Foulkes NS, Mattei MG, Sassone-Corsi P (Nov 1993). "Human CREM gene: evolutionary conservation, chromosomal localization, and inducibility of the transcript". Cell Growth & Differentiation 4 (11): 931–7. PMID 7916662.
3. "Entrez Gene: CREM cAMP responsive element modulator".
4. Fimia GM, De Cesare D, Sassone-Corsi P (Nov 2000). "A family of LIM-only transcriptional coactivators: tissue-specific expression and selective activation of CREB and CREM". Molecular and Cellular Biology 20 (22): 8613–22. doi:10.1128/MCB.20.22.8613-8622.2000. PMC 102166. PMID 11046156.
5. Fimia GM, De Cesare D, Sassone-Corsi P (Mar 1999). "CBP-independent activation of CREM and CREB by the LIM-only protein ACT". Nature 398 (6723): 165–9. doi:10.1038/18237. PMID 10086359.

Further reading

• Don J, Stelzer G (Feb 2002). "The expanding family of CREB/CREM transcription factors that are involved with spermatogenesis". Molecular and Cellular Endocrinology 187 (1-2): 115–24. doi:10.1016/S0303-7207(01)00696-7. PMID 11988318.
• Yan C, Miller CL, Abe J (Mar 2007). "Regulation of phosphodiesterase 3 and inducible cAMP early repressor in the heart". Circulation Research 100 (4): 489–501. doi:10.1161/01.RES.0000258451.44949.d7. PMID 17332439.
• Pongubala JM, Atchison ML (Apr 1995). "Activating transcription factor 1 and cyclic AMP response element modulator can modulate the activity of the immunoglobulin kappa 3' enhancer". The Journal of Biological Chemistry 270 (17): 10304–13. doi:10.1074/jbc.270.17.10304. PMID 7730336.
• Walker WH, Sanborn BM, Habener JF (Dec 1994). "An isoform of transcription factor CREM expressed during spermatogenesis lacks the phosphorylation domain and represses cAMP-induced transcription". Proceedings of the National Academy of Sciences of the United States of America 91 (26): 12423–7. doi:10.1073/pnas.91.26.12423. PMC 45450. PMID 7809053.
• Fujimoto T, Fujisawa J, Yoshida M (Feb 1994). "Novel isoforms of human cyclic AMP-responsive element modulator (hCREM) mRNA". Journal of Biochemistry 115 (2): 298–303. PMID 8206879.
• de Groot RP, den Hertog J, Vandenheede JR, Goris J, Sassone-Corsi P (Oct 1993). "Multiple and cooperative phosphorylation events regulate the CREM activator function". The EMBO Journal 12 (10): 3903–11. PMC 413673. PMID 8404858.
• Bodor J, Walker W, Flemington E, Spetz AL, Habener JF (Dec 1995). "Modulation of Tax and PKA-mediated expression of HTLV-I promoter via cAMP response element binding and modulator proteins CREB and CREM". FEBS Letters 377 (3): 413–8. doi:10.1016/0014-5793(95)01299-0. PMID 8549766.
• Nantel F, Monaco L, Foulkes NS, Masquilier D, LeMeur M, Henriksén K, Dierich A, Parvinen M, Sassone-Corsi P (Mar 1996). "Spermiogenesis deficiency and germ-cell apoptosis in CREM-mutant mice". Nature 380 (6570): 159–62. doi:10.1038/380159a0. PMID 8600390.
• Blendy JA, Kaestner KH, Weinbauer GF, Nieschlag E, Schütz G (Mar 1996). "Severe impairment of spermatogenesis in mice lacking the CREM gene". Nature 380 (6570): 162–5. doi:10.1038/380162a0. PMID 8600391.
• Bodor J, Spetz AL, Strominger JL, Habener JF (Apr 1996). "cAMP inducibility of transcriptional repressor ICER in developing and mature human T lymphocytes". Proceedings of the National Academy of Sciences of the United States of America 93 (8): 3536–41. doi:10.1073/pnas.93.8.3536. PMC 39645. PMID 8622971.
• Gellersen B, Kempf R, Telgmann R (Jan 1997). "Human endometrial stromal cells express novel isoforms of the transcriptional modulator CREM and up-regulate ICER in the course of decidualization". Molecular Endocrinology 11 (1): 97–113. doi:10.1210/me.11.1.97. PMID 8994192.
• Laurance ME, Kwok RP, Huang MS, Richards JP, Lundblad JR, Goodman RH (Jan 1997). "Differential activation of viral and cellular promoters by human T-cell lymphotropic virus-1 tax and cAMP-responsive element modulator isoforms". The Journal of Biological Chemistry 272 (5): 2646–51. doi:10.1074/jbc.272.5.2646. PMID 9006899.
• Bonny C, Cooker LA, Goldberg E (Mar 1998). "Deoxyribonucleic acid-protein interactions and expression of the human testis-specific lactate dehydrogenase promoter: transcription factor Sp1 plays a major role". Biology of Reproduction 58 (3): 754–9. doi:10.1095/biolreprod58.3.754. PMID 9510963.
• Müller FU, Bokník P, Knapp J, Neumann J, Vahlensieck U, Oetjen E, Scheld HH, Schmitz W (Sep 1998). "Identification and expression of a novel isoform of cAMP response element modulator in the human heart". FASEB Journal 12 (12): 1191–9. PMID 9737722.
• Fimia GM, De Cesare D, Sassone-Corsi P (Mar 1999). "CBP-independent activation of CREM and CREB by the LIM-only protein ACT". Nature 398 (6723): 165–9. doi:10.1038/18237. PMID 10086359.
• Pati D, Meistrich ML, Plon SE (Jul 1999). "Human Cdc34 and Rad6B ubiquitin-conjugating enzymes target repressors of cyclic AMP-induced transcription for proteolysis". Molecular and Cellular Biology 19 (7): 5001–13. doi:10.1128/mcb.19.7.5001. PMC 84326. PMID 10373550.
• Inada A, Someya Y, Yamada Y, Ihara Y, Kubota A, Ban N, Watanabe R, Tsuda K, Seino Y (Jul 1999). "The cyclic AMP response element modulator family regulates the insulin gene transcription by interacting with transcription factor IID". The Journal of Biological Chemistry 274 (30): 21095–103. doi:10.1074/jbc.274.30.21095. PMID 10409662.
• Zauli G, Secchiero P, Rodella L, Gibellini D, Mirandola P, Mazzoni M, Milani D, Dowd DR, Capitani S, Vitale M (Feb 2000). "HIV-1 Tat-mediated inhibition of the tyrosine hydroxylase gene expression in dopaminergic neuronal cells". The Journal of Biological Chemistry 275 (6): 4159–65. doi:10.1074/jbc.275.6.4159. PMID 10660577.

External links

• CREM protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.