CEBPD
| CCAAT/enhancer binding protein (C/EBP), delta | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | CEBPD ; C/EBP-delta; CELF; CRP3; NF-IL6-beta | ||||||||||||
| External IDs | OMIM: 116898 MGI: 103573 HomoloGene: 3808 GeneCards: CEBPD Gene | ||||||||||||
| |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 1052 | 12609 | |||||||||||
| Ensembl | ENSG00000221869 | n/a | |||||||||||
| UniProt | P49716 | Q00322 | |||||||||||
| RefSeq (mRNA) | NM_005195 | NM_007679 | |||||||||||
| RefSeq (protein) | NP_005186 | NP_031705 | |||||||||||
| Location (UCSC) |
Chr 8: 47.74 – 47.74 Mb | n/a | |||||||||||
| PubMed search | |||||||||||||
CCAAT/enhancer-binding protein delta is a protein that in humans is encoded by the CEBPD gene.[1][2]
Function
The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-alpha. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses, and may be involved in the regulation of genes associated with activation and/or differentiation of macrophages.[3]
Functions
CEBPD is involved in regulation of apoptosis and cell proliferation. It probably acts as tumor suppressor. [4]
One study in mice showed that CEBPD prevents development of tubular injury and tubulointerstitial fibrogenesis during the progression of chronic obstructive nephropathy. [5]
Interactions
CEBPD has been shown to interact with Mothers against decapentaplegic homolog 3.[6]
See also
References
- ↑ Cao Z, Umek RM, McKnight SL (Sep 1991). "Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells". Genes & Development 5 (9): 1538–52. doi:10.1101/gad.5.9.1538. PMID 1840554.
- ↑ Williams SC, Cantwell CA, Johnson PF (Sep 1991). "A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro". Genes & Development 5 (9): 1553–67. doi:10.1101/gad.5.9.1553. PMID 1884998.
- ↑ "Entrez Gene: CEBPD CCAAT/enhancer binding protein (C/EBP), delta".
- ↑ Gery S, Tanosaki S, Hofmann WK, Koppel A, Koeffler HP (Feb 2005). "C/EBPdelta expression in a BCR-ABL-positive cell line induces growth arrest and myeloid differentiation". Oncogene 24 (9): 1589–97. doi:10.1038/sj.onc.1208393. PMID 15674331.
- ↑ Duitman J, Borensztajn KS, Pulskens WP, Leemans JC, Florquin S, Spek CA (Jan 2014). "CCAAT-enhancer binding protein delta (C/EBPδ) attenuates tubular injury and tubulointerstitial fibrogenesis during chronic obstructive nephropathy". Laboratory Investigation; A Journal of Technical Methods and Pathology 94 (1): 89–97. doi:10.1038/labinvest.2013.127. PMID 24247561.
- ↑ Choy L, Derynck R (Mar 2003). "Transforming growth factor-beta inhibits adipocyte differentiation by Smad3 interacting with CCAAT/enhancer-binding protein (C/EBP) and repressing C/EBP transactivation function". The Journal of Biological Chemistry 278 (11): 9609–19. doi:10.1074/jbc.M212259200. PMID 12524424.
Further reading
- Sladek FM, Darnell JE (Apr 1992). "Mechanisms of liver-specific gene expression". Current Opinion in Genetics & Development 2 (2): 256–9. doi:10.1016/S0959-437X(05)80282-5. PMID 1638120.
- Kinoshita S, Akira S, Kishimoto T (Feb 1992). "A member of the C/EBP family, NF-IL6 beta, forms a heterodimer and transcriptionally synergizes with NF-IL6". Proceedings of the National Academy of Sciences of the United States of America 89 (4): 1473–6. doi:10.1073/pnas.89.4.1473. PMC 48473. PMID 1741402.
- Nagulapalli S, Pongubala JM, Atchison ML (Nov 1995). "Multiple proteins physically interact with PU.1. Transcriptional synergy with NF-IL6 beta (C/EBP delta, CRP3)". Journal of Immunology 155 (9): 4330–8. PMID 7594592.
- Wood S, Schertzer M, Yaremko ML (1995). "Sequence identity locates CEBPD and FGFR1 to mapped human loci within proximal 8p". Cytogenetics and Cell Genetics 70 (3-4): 188–91. doi:10.1159/000134030. PMID 7789168.
- Cleutjens CB, van Eekelen CC, van Dekken H, Smit EM, Hagemeijer A, Wagner MJ, Wells DE, Trapman J (May 1993). "The human C/EBP delta (CRP3/CELF) gene: structure and chromosomal localization". Genomics 16 (2): 520–3. doi:10.1006/geno.1993.1220. PMID 8314590.
- Chen PL, Riley DJ, Chen Y, Lee WH (Nov 1996). "Retinoblastoma protein positively regulates terminal adipocyte differentiation through direct interaction with C/EBPs". Genes & Development 10 (21): 2794–804. doi:10.1101/gad.10.21.2794. PMID 8946919.
- Xia C, Cheshire JK, Patel H, Woo P (Dec 1997). "Cross-talk between transcription factors NF-kappa B and C/EBP in the transcriptional regulation of genes". The International Journal of Biochemistry & Cell Biology 29 (12): 1525–39. doi:10.1016/S1357-2725(97)00083-6. PMID 9570146.
- Zhu Y, Saunders MA, Yeh H, Deng WG, Wu KK (Mar 2002). "Dynamic regulation of cyclooxygenase-2 promoter activity by isoforms of CCAAT/enhancer-binding proteins". The Journal of Biological Chemistry 277 (9): 6923–8. doi:10.1074/jbc.M108075200. PMID 11741938.
- Angeloni D, Lee JD, Johnson BE, Teh BT, Dean M, Lerman MI, Sterneck E (Dec 2001). "C306A single nucleotide polymorphism in the human CEBPD gene that maps at 8p11.1-p11.2". Molecular and Cellular Probes 15 (6): 395–7. doi:10.1006/mcpr.2001.0377. PMID 11851384.
- Gao H, Parkin S, Johnson PF, Schwartz RC (Oct 2002). "C/EBP gamma has a stimulatory role on the IL-6 and IL-8 promoters". The Journal of Biological Chemistry 277 (41): 38827–37. doi:10.1074/jbc.M206224200. PMID 12177065.
- Dearth LR, DeWille J (Mar 2003). "Posttranscriptional and posttranslational regulation of C/EBP delta in G0 growth-arrested mammary epithelial cells". The Journal of Biological Chemistry 278 (13): 11246–55. doi:10.1074/jbc.M207930200. PMID 12554732.
- Milde-Langosch K, Löning T, Bamberger AM (May 2003). "Expression of the CCAAT/enhancer-binding proteins C/EBPalpha, C/EBPbeta and C/EBPdelta in breast cancer: correlations with clinicopathologic parameters and cell-cycle regulatory proteins". Breast Cancer Research and Treatment 79 (2): 175–85. doi:10.1023/A:1023929504884. PMID 12825852.
- Kovács KA, Steinmann M, Magistretti PJ, Halfon O, Cardinaux JR (Sep 2003). "CCAAT/enhancer-binding protein family members recruit the coactivator CREB-binding protein and trigger its phosphorylation". The Journal of Biological Chemistry 278 (38): 36959–65. doi:10.1074/jbc.M303147200. PMID 12857754.
- Chen YW, Hubal MJ, Hoffman EP, Thompson PD, Clarkson PM (Dec 2003). "Molecular responses of human muscle to eccentric exercise". Journal of Applied Physiology 95 (6): 2485–94. doi:10.1152/japplphysiol.01161.2002. PMID 12937035.
- Li R, Strohmeyer R, Liang Z, Lue LF, Rogers J (Sep 2004). "CCAAT/enhancer binding protein delta (C/EBPdelta) expression and elevation in Alzheimer's disease". Neurobiology of Aging 25 (8): 991–9. doi:10.1016/j.neurobiolaging.2003.10.016. PMID 15212823.
- Sivko GS, Sanford DC, Dearth LD, Tang D, DeWille JW (Nov 2004). "CCAAT/Enhancer binding protein delta (c/EBPdelta) regulation and expression in human mammary epithelial cells: II. Analysis of activating signal transduction pathways, transcriptional, post-transcriptional, and post-translational control". Journal of Cellular Biochemistry 93 (4): 844–56. doi:10.1002/jcb.20224. PMID 15389878.
External links
- CEBPD protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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