TEAD2

TEA domain family member 2
PDB rendering based on 2hzd.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3L15​
Identifiers
Symbols	TEAD2 ; ETF; TEAD-2; TEF-4; TEF4
External IDs	OMIM: 601729 MGI: 104904 HomoloGene: 19662 GeneCards: TEAD2 Gene
Gene ontology Molecular function • DNA binding • transcription factor activity, sequence-specific DNA binding • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding • protein binding Cellular component • nucleus • nucleoplasm • transcription factor complex Biological process • vasculogenesis • neural tube closure • embryonic heart tube morphogenesis • regulation of transcription, DNA-templated • transcription initiation from RNA polymerase II promoter • gene expression • notochord development • hippo signaling • positive regulation of transcription from RNA polymerase II promoter • paraxial mesoderm development • lateral mesoderm development • negative regulation of cell death • cellular response to retinoic acid • regulation of stem cell differentiation Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8463	21677
Ensembl	ENSG00000074219	ENSMUSG00000030796
UniProt	Q15562	P48301
RefSeq (mRNA)	NM_001256658	NM_001285498
RefSeq (protein)	NP_001243587	NP_001272427
Location (UCSC)	Chr 19: 49.34 – 49.36 Mb	Chr 7: 45.22 – 45.23 Mb
PubMed search

Transcriptional enhancer factor TEF-4 also known as TEA domain family member 2 (TEAD-2) is a protein that in humans is encoded by the TEAD2 gene.^[1][2] TEAD-2 is a transcription factor.

Function

TEAD2 is a member of the mammalian TEAD transcription factor family (initially named the transcriptional enhancer factor (TEF) family), which contain the TEA/ATTS DNA-binding domain.^[3]

Clinical significance

Recent animal models indicating a possible association of TEAD2 with anencephaly.^[4]

References

1. Jacquemin P, Hwang JJ, Martial JA, Dollé P, Davidson I (September 1996). "A novel family of developmentally regulated mammalian transcription factors containing the TEA/ATTS DNA binding domain". J. Biol. Chem. 271 (36): 21775–85. doi:10.1074/jbc.271.36.21775. PMID 8702974.
2. Jacquemin P, Depetris D, Mattei MG, Martial JA, Davidson I (January 1999). "Localization of human transcription factor TEF-4 and TEF-5 (TEAD2, TEAD3) genes to chromosomes 19q13.3 and 6p21.2 using fluorescence in situ hybridization and radiation hybrid analysis". Genomics 55 (1): 127–9. doi:10.1006/geno.1998.5628. PMID 9889009.
3. Bürglin, TR (Jul 1991). "The TEA domain: a novel, highly conserved DNA-binding motif". Cell 66 (1): 11–12. doi:10.1016/0092-8674(91)90132-I. PMID 2070413.
4. Kaneko KJ, Kohn MJ, Liu C, Depamphilis ML (2007). "Transcription factor TEAD2 is involved in neural tube closure". Genesis 45 (9): 577–87. doi:10.1002/dvg.20330. PMC 2765819. PMID 17868131.

Further reading

• Vaudin P, Delanoue R, Davidson I, et al. (1999). "TONDU (TDU), a novel human protein related to the product of vestigial (vg) gene of Drosophila melanogaster interacts with vertebrate TEF factors and substitutes for Vg function in wing formation.". Development 126 (21): 4807–16. PMID 10518497.
• Zhao B, Ye X, Yu J, et al. (2008). "TEAD mediates YAP-dependent gene induction and growth control.". Genes Dev. 22 (14): 1962–71. doi:10.1101/gad.1664408. PMC 2492741. PMID 18579750.
• Belandia B, Parker MG (2000). "Functional interaction between the p160 coactivator proteins and the transcriptional enhancer factor family of transcription factors.". J. Biol. Chem. 275 (40): 30801–5. doi:10.1074/jbc.C000484200. PMID 10934189.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Tian W, Yu J, Tomchick DR, et al. (2010). "Structural and functional analysis of the YAP-binding domain of human TEAD2.". Proc. Natl. Acad. Sci. U.S.A. 107 (16): 7293–8. doi:10.1073/pnas.1000293107. PMC 2867681. PMID 20368466.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Zhang H, Liu CY, Zha ZY, et al. (2009). "TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition.". J. Biol. Chem. 284 (20): 13355–62. doi:10.1074/jbc.M900843200. PMC 2679435. PMID 19324877.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Vassilev A, Kaneko KJ, Shu H, et al. (2001). "TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm.". Genes Dev. 15 (10): 1229–41. doi:10.1101/gad.888601. PMC 313800. PMID 11358867.

External links

• TEAD2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)