CREB3

CAMP responsive element binding protein 3
Identifiers
Symbols	CREB3 ; LUMAN; LZIP; sLZIP
External IDs	OMIM: 606443 MGI: 99946 HomoloGene: 31375 GeneCards: CREB3 Gene
Gene ontology Molecular function • RNA polymerase II regulatory region sequence-specific DNA binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • DNA binding • chromatin binding • transcription factor activity, sequence-specific DNA binding • protein binding • cAMP response element binding protein binding • CCR1 chemokine receptor binding • cAMP response element binding • protein homodimerization activity • protein dimerization activity Cellular component • Golgi membrane • nucleus • cytoplasm • endoplasmic reticulum • endoplasmic reticulum membrane • Golgi apparatus • cytosol • membrane • integral component of membrane • nuclear body • integral component of endoplasmic reticulum membrane • neuronal cell body Biological process • regulation of cell growth • positive regulation of defense response to virus by host • transcription, DNA-templated • transcription from RNA polymerase II promoter • chemotaxis • positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response • viral process • establishment of viral latency • release from viral latency • positive regulation of cell migration • response to endoplasmic reticulum stress • regulation of cell proliferation • cytoplasmic sequestering of transcription factor • negative regulation of cell cycle • positive regulation of transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter • induction of positive chemotaxis • positive regulation of calcium ion transport • positive regulation of monocyte chemotaxis • positive regulation of deacetylase activity • negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway • negative regulation of ligand-dependent nuclear receptor transcription coactivator activity Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10488	12913
Ensembl	ENSG00000107175	ENSMUSG00000028466
UniProt	O43889	Q61817
RefSeq (mRNA)	NM_006368	NM_013497
RefSeq (protein)	NP_006359	NP_038525
Location (UCSC)	Chr 9: 35.73 – 35.74 Mb	Chr 4: 43.56 – 43.57 Mb
PubMed search

Cyclic AMP-responsive element-binding protein 3 is a protein that in humans is encoded by the CREB3 gene.^[1][2]

This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-responsive element, an octameric palindrome. The protein interacts with host cell factor C1, which also associates with the herpes simplex virus (HSV) protein VP16 that induces transcription of HSV immediate-early genes. This protein and VP16 both bind to the same site on host cell factor C1. It is thought that the interaction between this protein and host cell factor C1 plays a role in the establishment of latency during HSV infection. An additional transcript variant has been identified, but its biological validity has not been determined.^[2]

See also

• CREB

Interactions

CREB3 has been shown to interact with Host cell factor C1.^[3][4]

References

1. Lu R, Yang P, O'Hare P, Misra V (Sep 1997). "Luman, a new member of the CREB/ATF family, binds to herpes simplex virus VP16-associated host cellular factor". Mol Cell Biol 17 (9): 5117–26. PMC 232362. PMID 9271389.
2. "Entrez Gene: CREB3 cAMP responsive element binding protein 3".
3. Lu, R; Yang P; Padmakumar S; Misra V (Aug 1998). "The herpesvirus transactivator VP16 mimics a human basic domain leucine zipper protein, luman, in its interaction with HCF". J. Virol. (UNITED STATES) 72 (8): 6291–7. ISSN 0022-538X. PMC 109766. PMID 9658067.
4. Freiman, R N; Herr W (Dec 1997). "Viral mimicry: common mode of association with HCF by VP16 and the cellular protein LZIP". Genes Dev. (UNITED STATES) 11 (23): 3122–7. doi:10.1101/gad.11.23.3122. ISSN 0890-9369. PMC 316754. PMID 9389645.

Further reading

• Freiman RN, Herr W (1998). "Viral mimicry: common mode of association with HCF by VP16 and the cellular protein LZIP.". Genes Dev. 11 (23): 3122–7. doi:10.1101/gad.11.23.3122. PMC 316754. PMID 9389645.
• Lu R, Yang P, Padmakumar S, Misra V (1998). "The herpesvirus transactivator VP16 mimics a human basic domain leucine zipper protein, luman, in its interaction with HCF.". J. Virol. 72 (8): 6291–7. PMC 109766. PMID 9658067.
• Lu R, Misra V (2000). "Potential role for luman, the cellular homologue of herpes simplex virus VP16 (alpha gene trans-inducing factor), in herpesvirus latency.". J. Virol. 74 (2): 934–43. doi:10.1128/JVI.74.2.934-943.2000. PMC 111614. PMID 10623756.
• Mahajan SS, Wilson AC (2000). "Mutations in host cell factor 1 separate its role in cell proliferation from recruitment of VP16 and LZIP.". Mol. Cell. Biol. 20 (3): 919–28. doi:10.1128/MCB.20.3.919-928.2000. PMC 85209. PMID 10629049.
• Jin DY, Wang HL, Zhou Y; et al. (2000). "Hepatitis C virus core protein-induced loss of LZIP function correlates with cellular transformation.". EMBO J. 19 (4): 729–40. doi:10.1093/emboj/19.4.729. PMC 305611. PMID 10675342.
• Luciano RL, Wilson AC (2000). "N-terminal transcriptional activation domain of LZIP comprises two LxxLL motifs and the host cell factor-1 binding motif.". Proc. Natl. Acad. Sci. U.S.A. 97 (20): 10757–62. doi:10.1073/pnas.190062797. PMC 27096. PMID 10984507.
• Raggo C, Rapin N, Stirling J; et al. (2002). "Luman, the cellular counterpart of herpes simplex virus VP16, is processed by regulated intramembrane proteolysis.". Mol. Cell. Biol. 22 (16): 5639–49. doi:10.1128/MCB.22.16.5639-5649.2002. PMC 133973. PMID 12138176.
• Mahajan SS, Little MM, Vazquez R, Wilson AC (2003). "Interaction of HCF-1 with a cellular nuclear export factor.". J. Biol. Chem. 277 (46): 44292–9. doi:10.1074/jbc.M205440200. PMID 12235138.
• Luciano RL, Wilson AC (2002). "An activation domain in the C-terminal subunit of HCF-1 is important for transactivation by VP16 and LZIP.". Proc. Natl. Acad. Sci. U.S.A. 99 (21): 13403–8. doi:10.1073/pnas.202200399. PMC 129685. PMID 12271126.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ko J, Jang SW, Kim YS; et al. (2004). "Human LZIP binds to CCR1 and differentially affects the chemotactic activities of CCR1-dependent chemokines.". FASEB J. 18 (7): 890–2. doi:10.1096/fj.03-0867fje. PMID 15001559.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Misra V, Rapin N, Akhova O; et al. (2005). "Zhangfei is a potent and specific inhibitor of the host cell factor-binding transcription factor Luman.". J. Biol. Chem. 280 (15): 15257–66. doi:10.1074/jbc.M500728200. PMID 15705566.
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Liang G, Audas TE, Li Y; et al. (2007). "Luman/CREB3 induces transcription of the endoplasmic reticulum (ER) stress response protein Herp through an ER stress response element.". Mol. Cell. Biol. 26 (21): 7999–8010. doi:10.1128/MCB.01046-06. PMC 1636730. PMID 16940180.
• Blot G, Lopez-Vergès S, Treand C; et al. (2007). "Luman, a new partner of HIV-1 TMgp41, interferes with Tat-mediated transcription of the HIV-1 LTR.". J. Mol. Biol. 364 (5): 1034–47. doi:10.1016/j.jmb.2006.09.080. PMID 17054986.
• Jang SW, Kim YS, Lee YH, Ko J (2007). "Role of human LZIP in differential activation of the NF-kappaB pathway that is induced by CCR1-dependent chemokines.". J. Cell. Physiol. 211 (3): 630–7. doi:10.1002/jcp.20968. PMID 17192849.
• Jang SW, Kim YS, Kim YR; et al. (2007). "Regulation of human LZIP expression by NF-kappaB and its involvement in monocyte cell migration induced by Lkn-1.". J. Biol. Chem. 282 (15): 11092–100. doi:10.1074/jbc.M607962200. PMID 17296613.

External links

• CREB3 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.