HOXA3

Homeobox A3
Identifiers
Symbols	HOXA3 ; HOX1; HOX1E
External IDs	OMIM: 142954 MGI: 96175 HomoloGene: 40725 GeneCards: HOXA3 Gene
Gene ontology Molecular function • transcription factor activity, sequence-specific DNA binding • protein binding • sequence-specific DNA binding • HMG box domain binding Cellular component • nucleoplasm Biological process • angiogenesis • blood vessel remodeling • transcription, DNA-templated • regulation of transcription, DNA-templated • positive regulation of cell proliferation • anterior/posterior pattern specification • specification of organ position • glossopharyngeal nerve morphogenesis • thyroid gland development • thymus development • organ formation • embryonic skeletal system morphogenesis • cartilage development • parathyroid gland development Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3200	15400
Ensembl	ENSG00000105997	ENSMUSG00000079560
UniProt	O43365	P02831
RefSeq (mRNA)	NM_030661	NM_010452
RefSeq (protein)	NP_109377	NP_034582
Location (UCSC)	Chr 7: 27.11 – 27.15 Mb	Chr 6: 52.17 – 52.21 Mb
PubMed search

Homeobox protein Hox-A3 is a protein that in humans is encoded by the HOXA3 gene.^[1][2][3]

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Three transcript variants encoding two different isoforms have been found for this gene.^[3]

Regulation

The HOXA3 gene is repressed by the microRNA miR-10a.^[4]

See also

• Homeobox

References

1. McAlpine PJ, Shows TB (Aug 1990). "Nomenclature for human homeobox genes". Genomics 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
2. Scott MP (Dec 1992). "Vertebrate homeobox gene nomenclature". Cell 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459.
3. "Entrez Gene: HOXA3 homeobox A3".
4. Han L, Witmer PD, Casey E, Valle D, Sukumar S (2007). "DNA methylation regulates MicroRNA expression". Cancer Biol Ther 6 (8): 1284–8. PMID 17660710.

Further reading

• Apiou F, Flagiello D, Cillo C, et al. (1996). "Fine mapping of human HOX gene clusters". Cytogenet. Cell Genet. 73 (1–2): 114–5. doi:10.1159/000134320. PMID 8646877.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Manley NR, Capecchi MR (1998). "Hox group 3 paralogs regulate the development and migration of the thymus, thyroid, and parathyroid glands". Dev. Biol. 195 (1): 1–15. doi:10.1006/dbio.1997.8827. PMID 9520319.
• <Please add first missing authors to populate metadata.> (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
• Mulder GB, Manley N, Maggio-Price L (1999). "Retinoic acid-induced thymic abnormalities in the mouse are associated with altered pharyngeal morphology, thymocyte maturation defects, and altered expression of Hoxa3 and Pax1". Teratology 58 (6): 263–75. doi:10.1002/(SICI)1096-9926(199812)58:6<263::AID-TERA8>3.0.CO;2-A. PMID 9894676.
• Manzanares M, Nardelli J, Gilardi-Hebenstreit P, et al. (2002). "Krox20 and kreisler co-operate in the transcriptional control of segmental expression of Hoxb3 in the developing hindbrain". EMBO J. 21 (3): 365–76. doi:10.1093/emboj/21.3.365. PMC 125344. PMID 11823429.
• Kosaki K, Kosaki R, Suzuki T, et al. (2002). "Complete mutation analysis panel of the 39 human HOX genes". Teratology 65 (2): 50–62. doi:10.1002/tera.10009. PMID 11857506.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kim J, Bhinge AA, Morgan XC, Iyer VR (2005). "Mapping DNA-protein interactions in large genomes by sequence tag analysis of genomic enrichment". Nat. Methods 2 (1): 47–53. doi:10.1038/nmeth726. PMID 15782160.
• Wissmüller S, Kosian T, Wolf M, et al. (2006). "The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors". Nucleic Acids Res. 34 (6): 1735–44. doi:10.1093/nar/gkl105. PMC 1421504. PMID 16582099.

External links

• HOXA3 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.