HOXB7

Homeobox B7
PDB rendering based on 1ahd.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1ahd​, 1hom​, 1san​, 2hoa​, 9ant​
Identifiers
Symbols	HOXB7 ; HHO.C1; HOX2; HOX2C; Hox-2.3
External IDs	OMIM: 142962 MGI: 96188 HomoloGene: 55828 GeneCards: HOXB7 Gene
Gene ontology Molecular function • transcription factor activity, sequence-specific DNA binding • protein binding • sequence-specific DNA binding Cellular component • nucleus • nucleoplasm • cytoplasm Biological process • transcription, DNA-templated • regulation of transcription, DNA-templated • multicellular organismal development • anterior/posterior pattern specification • myeloid cell differentiation • embryonic skeletal system morphogenesis • positive regulation of branching involved in ureteric bud morphogenesis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3217	15415
Ensembl	ENSG00000260027	ENSMUSG00000038721
UniProt	P09629	P09024
RefSeq (mRNA)	NM_004502	NM_010460
RefSeq (protein)	NP_004493	NP_034590
Location (UCSC)	Chr 17: 48.61 – 48.63 Mb	Chr 11: 96.29 – 96.29 Mb
PubMed search

Homeobox protein Hox-B7 is a protein that in humans is encoded by the HOXB7 gene.^[1][2]

Function

This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of melanoma and ovarian carcinoma.^[3]

Interactions

HOXB7 has been shown to interact with PBX1^[4] and CREB-binding protein.^[5]

See also

• Homeobox

References

1. McAlpine PJ, Shows TB (August 1990). "Nomenclature for human homeobox genes". Genomics 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
2. Scott MP (December 1992). "Vertebrate homeobox gene nomenclature". Cell 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459.
3. "Entrez Gene: HOXB7 homeobox B7".
4. Chang CP, Shen WF, Rozenfeld S, Lawrence HJ, Largman C, Cleary ML (March 1995). "Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins". Genes Dev. 9 (6): 663–74. doi:10.1101/gad.9.6.663. PMID 7729685.
5. Chariot A, van Lint C, Chapelier M, Gielen J, Merville MP, Bours V (July 1999). "CBP and histone deacetylase inhibition enhance the transactivation potential of the HOXB7 homeodomain-containing protein". Oncogene 18 (27): 4007–14. doi:10.1038/sj.onc.1202776. PMID 10435624.

Further reading

• Baier LJ, Hannibal MC, Hanley EW, Nabel GJ (1991). "Lymphoid expression and TATAA binding of a human protein containing an Antennapedia homeodomain". Blood 78 (4): 1047–55. PMID 1678287.
• Peverali FA, D'Esposito M, Acampora D, Bunone G, Negri M, Faiella A, Stornaiuolo A, Pannese M, Migliaccio E, Simeone A (1990). "Expression of HOX homeogenes in human neuroblastoma cell culture lines". Differentiation 45 (1): 61–9. doi:10.1111/j.1432-0436.1990.tb00458.x. PMID 1981366.
• Giampaolo A, Acampora D, Zappavigna V, Pannese M, D'Esposito M, Carè A, Faiella A, Stornaiuolo A, Russo G, Simeone A (1989). "Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system". Differentiation 40 (3): 191–7. doi:10.1111/j.1432-0436.1989.tb00598.x. PMID 2570724.
• Shen WF, Largman C, Lowney P, Corral JC, Detmer K, Hauser CA, Simonitch TA, Hack FM, Lawrence HJ (1989). "Lineage-restricted expression of homeobox-containing genes in human hematopoietic cell lines". Proc. Natl. Acad. Sci. U.S.A. 86 (21): 8536–40. doi:10.1073/pnas.86.21.8536. PMC 298317. PMID 2573064.
• Acampora D, D'Esposito M, Faiella A, Pannese M, Migliaccio E, Morelli F, Stornaiuolo A, Nigro V, Simeone A, Boncinelli E (1989). "The human HOX gene family". Nucleic Acids Res. 17 (24): 10385–402. doi:10.1093/nar/17.24.10385. PMC 335308. PMID 2574852.
• Boncinelli E, Acampora D, Pannese M, D'Esposito M, Somma R, Gaudino G, Stornaiuolo A, Cafiero M, Faiella A, Simeone A (1989). "Organization of human class I homeobox genes". Genome 31 (2): 745–56. doi:10.1139/g89-133. PMID 2576652.
• Simeone A, Mavilio F, Acampora D, Giampaolo A, Faiella A, Zappavigna V, D'Esposito M, Pannese M, Russo G, Boncinelli E (1987). "Two human homeobox genes, c1 and c8: structure analysis and expression in embryonic development". Proc. Natl. Acad. Sci. U.S.A. 84 (14): 4914–8. doi:10.1073/pnas.84.14.4914. PMC 305217. PMID 2885844.
• Lill MC, Fuller JF, Herzig R, Crooks GM, Gasson JC (1995). "The role of the homeobox gene, HOX B7, in human myelomonocytic differentiation". Blood 85 (3): 692–7. PMID 7530503.
• Chang CP, Shen WF, Rozenfeld S, Lawrence HJ, Largman C, Cleary ML (1995). "Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins". Genes Dev. 9 (6): 663–74. doi:10.1101/gad.9.6.663. PMID 7729685.
• Corsetti MT, Levi G, Lancia F, Sanseverino L, Ferrini S, Boncinelli E, Corte G (1995). "Nucleolar localisation of three Hox homeoproteins". J. Cell. Sci. 108 (1): 187–93. PMID 7738096.
• Inamori K, Takeshita K, Chiba S, Yazaki Y, Hirai H (1993). "Identification of homeobox genes expressed in human T-lymphocytes". Biochem. Biophys. Res. Commun. 196 (1): 203–8. doi:10.1006/bbrc.1993.2235. PMID 8105782.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Miano JM, Firulli AB, Olson EN, Hara P, Giachelli CM, Schwartz SM (1996). "Restricted expression of homeobox genes distinguishes fetal from adult human smooth muscle cells". Proc. Natl. Acad. Sci. U.S.A. 93 (2): 900–5. doi:10.1073/pnas.93.2.900. PMC 40155. PMID 8570656.
• Apiou F, Flagiello D, Cillo C, Malfoy B, Poupon MF, Dutrillaux B (1996). "Fine mapping of human HOX gene clusters". Cytogenet. Cell Genet. 73 (1-2): 114–5. doi:10.1159/000134320. PMID 8646877.
• Caré A, Silvani A, Meccia E, Mattia G, Stoppacciaro A, Parmiani G, Peschle C, Colombo MP (1996). "HOXB7 constitutively activates basic fibroblast growth factor in melanomas". Mol. Cell. Biol. 16 (9): 4842–51. doi:10.1128/mcb.16.9.4842. PMC 231486. PMID 8756643.
• LeBrun DP, Matthews BP, Feldman BJ, Cleary ML (1997). "The chimeric oncoproteins E2A-PBX1 and E2A-HLF are concentrated within spherical nuclear domains". Oncogene 15 (17): 2059–67. doi:10.1038/sj.onc.1201367. PMID 9366523.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Stelnicki EJ, Kömüves LG, Kwong AO, Holmes D, Klein P, Rozenfeld S, Lawrence HJ, Adzick NS, Harrison M, Largman C (1998). "HOX homeobox genes exhibit spatial and temporal changes in expression during human skin development". J. Invest. Dermatol. 110 (2): 110–5. doi:10.1046/j.1523-1747.1998.00092.x. PMID 9457903.

External links

• HOXB7 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.