HMGB3

High mobility group box 3
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2EQZ​, 2YQI​
Identifiers
Symbols	HMGB3 ; HMG-2a; HMG-4; HMG2A; HMG4
External IDs	OMIM: 300193 MGI: 1098219 HomoloGene: 84734 GeneCards: HMGB3 Gene
Gene ontology Molecular function • four-way junction DNA binding • chromatin binding • double-stranded DNA binding • protein binding • DNA binding, bending • poly(A) RNA binding Cellular component • nucleus • chromosome Biological process • DNA recombination • chromatin remodeling • regulation of transcription, DNA-templated • multicellular organismal development • DNA geometric change • negative regulation of B cell differentiation • negative regulation of myeloid cell differentiation Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3149	15354
Ensembl	ENSG00000029993	ENSMUSG00000015217
UniProt	O15347	O54879
RefSeq (mRNA)	NM_001301228	NM_008253
RefSeq (protein)	NP_001288157	NP_032279
Location (UCSC)	Chr X: 150.98 – 150.99 Mb	Chr X: 71.56 – 71.56 Mb
PubMed search

High-mobility group protein B3 is a protein that in humans is encoded by the HMGB3 gene.^[1][2]

References

1. Vaccari T, Beltrame M, Ferrari S, Bianchi ME (Aug 1998). "Hmg4, a new member of the Hmg1/2 gene family". Genomics 49 (2): 247–52. doi:10.1006/geno.1998.5214. PMID 9598312.
2. "Entrez Gene: HMGB3 high-mobility group box 3".

Further reading

• Davis DL, Burch JB (1992). "Isolation of a chicken HMG2 cDNA clone and evidence for an HMG2-specific 3'-untranslated region.". Gene 113 (2): 251–6. doi:10.1016/0378-1119(92)90403-C. PMID 1572546.
• Shirakawa H, Tsuda K, Yoshida M (1990). "Primary structure of non-histone chromosomal protein HMG2 revealed by the nucleotide sequence.". Biochemistry 29 (18): 4419–23. doi:10.1021/bi00470a022. PMID 2350545.
• Wilke K, Wiemann S, Gaul R, et al. (1997). "Isolation of human and mouse HMG2a cDNAs: evidence for an HMG2a-specific 3' untranslated region". Gene 198 (1–2): 269–74. doi:10.1016/S0378-1119(97)00324-7. PMID 9370291.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature 434 (7031): 325–37. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.

External links

• HMGB3 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)