ETV4

Ets variant 4
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4CO8​, 4UUV​
Identifiers
Symbols	ETV4 ; E1A-F; E1AF; PEA3; PEAS3
External IDs	OMIM: 600711 MGI: 99423 HomoloGene: 1504 GeneCards: ETV4 Gene
Gene ontology Molecular function • RNA polymerase II core promoter proximal region sequence-specific DNA binding • RNA polymerase II transcription factor activity, sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • protein binding Cellular component • nucleolus Biological process • transcription from RNA polymerase II promoter • motor neuron axon guidance • cell differentiation • negative regulation of mammary gland epithelial cell proliferation • positive regulation of transcription from RNA polymerase II promoter • stem cell differentiation • branching involved in mammary gland duct morphogenesis • regulation of branching involved in mammary gland duct morphogenesis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2118	18612
Ensembl	ENSG00000175832	ENSMUSG00000017724
UniProt	P43268	P28322
RefSeq (mRNA)	NM_001079675	NM_008815
RefSeq (protein)	NP_001073143	NP_032841
Location (UCSC)	Chr 17: 43.53 – 43.58 Mb	Chr 11: 101.77 – 101.79 Mb
PubMed search

ETS translocation variant 4 (ETV4), also known as polyoma enhancer activator 3 (PEA3), is a member of the PEA3 subfamily of Ets transcription factors.^[1][2]

References

1. Isobe M, Yamagishi F, Yoshida K, Higashino F, Fujinaga K (Jul 1995). "Assignment of the ets-related transcription factor E1A-F gene (ETV4) to human chromosome region 17q21". Genomics 28 (2): 357–9. doi:10.1006/geno.1995.1158. PMID 8530053.
2. "Entrez Gene: ETV4 Ets variant gene 4 (E1A enhancer binding protein, E1AF)".

Further reading

• Friedman LS, Ostermeyer EA, Lynch ED, Welcsh P, Szabo CI, Meza JE, Anderson LA, Dowd P, Lee MK, Rowell SE (Jan 1995). "22 genes from chromosome 17q21: cloning, sequencing, and characterization of mutations in breast cancer families and tumors". Genomics 25 (1): 256–63. doi:10.1016/0888-7543(95)80133-7. PMID 7774926.
• Liu SH, Peng BH, Ma JT, Liu YC, Ng SY (1995). "Serum response element associated transcription factors in mouse embryos: serum response factor, YY1, and PEA3 factor". Developmental Genetics 16 (3): 229–40. doi:10.1002/dvg.1020160303. PMID 7796532.
• Friedman LS, Ostermeyer EA, Lynch ED, Szabo CI, Anderson LA, Dowd P, Lee MK, Rowell SE, Boyd J, King MC (Dec 1994). "The search for BRCA1". Cancer Research 54 (24): 6374–82. PMID 7987831.
• Higashino F, Yoshida K, Fujinaga Y, Kamio K, Fujinaga K (Feb 1993). "Isolation of a cDNA encoding the adenovirus E1A enhancer binding protein: a new human member of the ets oncogene family". Nucleic Acids Research 21 (3): 547–53. doi:10.1093/nar/21.3.547. PMC 309151. PMID 8441666.
• Urano F, Umezawa A, Hong W, Kikuchi H, Hata J (Feb 1996). "A novel chimera gene between EWS and E1A-F, encoding the adenovirus E1A enhancer-binding protein, in extraosseous Ewing's sarcoma". Biochemical and Biophysical Research Communications 219 (2): 608–12. doi:10.1006/bbrc.1996.0281. PMID 8605035.
• Coutte L, Monté D, Baert J, de Launoit Y (Nov 1999). "Genomic organization of the human e1af gene,a member of Ets transcription factors". Gene 240 (1): 201–7. doi:10.1016/S0378-1119(99)00400-X. PMID 10564827.
• Mastrangelo T, Modena P, Tornielli S, Bullrich F, Testi MA, Mezzelani A, Radice P, Azzarelli A, Pilotti S, Croce CM, Pierotti MA, Sozzi G (Aug 2000). "A novel zinc finger gene is fused to EWS in small round cell tumor". Oncogene 19 (33): 3799–804. doi:10.1038/sj.onc.1203762. PMID 10949935.
• Davidson B, Goldberg I, Gotlieb WH, Kopolovic J, Ben-Baruch G, Reich R (Apr 2003). "PEA3 is the second Ets family transcription factor involved in tumor progression in ovarian carcinoma". Clinical Cancer Research 9 (4): 1412–9. PMID 12684413.
• Span PN, Manders P, Heuvel JJ, Beex LV, Sweep CG (May 2003). "E1AF expression levels are not associated with prognosis in human breast cancer". Breast Cancer Research and Treatment 79 (1): 129–31. doi:10.1023/A:1023338424677. PMID 12779089.
• Anderson NL, Polanski M, Pieper R, Gatlin T, Tirumalai RS, Conrads TP, Veenstra TD, Adkins JN, Pounds JG, Fagan R, Lobley A (Apr 2004). "The human plasma proteome: a nonredundant list developed by combination of four separate sources". Molecular & Cellular Proteomics 3 (4): 311–26. doi:10.1074/mcp.M300127-MCP200. PMID 14718574.
• Liu Y, Borchert GL, Phang JM (Apr 2004). "Polyoma enhancer activator 3, an ets transcription factor, mediates the induction of cyclooxygenase-2 by nitric oxide in colorectal cancer cells". The Journal of Biological Chemistry 279 (18): 18694–700. doi:10.1074/jbc.M308136200. PMID 14976201.
• Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (Sep 2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Research 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Davidson B, Goldberg I, Tell L, Vigdorchik S, Baekelandt M, Berner A, Kristensen GB, Reich R, Kopolovic J (2004). "The clinical role of the PEA3 transcription factor in ovarian and breast carcinoma in effusions". Clinical & Experimental Metastasis 21 (3): 191–9. doi:10.1023/B:CLIN.0000037703.37275.35. PMID 15387369.
• Fauquette V, Perrais M, Cerulis S, Jonckheere N, Ducourouble MP, Aubert JP, Pigny P, Van Seuningen I (Feb 2005). "The antagonistic regulation of human MUC4 and ErbB-2 genes by the Ets protein PEA3 in pancreatic cancer cells: implications for the proliferation/differentiation balance in the cells". The Biochemical Journal 386 (Pt 1): 35–45. doi:10.1042/BJ20040706. PMC 1134764. PMID 15461591.
• Zhu X, Jiang J, Shen H, Wang H, Zong H, Li Z, Yang Y, Niu Z, Liu W, Chen X, Hu Y, Gu J (Apr 2005). "Elevated beta1,4-galactosyltransferase I in highly metastatic human lung cancer cells. Identification of E1AF as important transcription activator". The Journal of Biological Chemistry 280 (13): 12503–16. doi:10.1074/jbc.M413631200. PMID 15611127.
• Takahashi A, Higashino F, Aoyagi M, Yoshida K, Itoh M, Kobayashi M, Totsuka Y, Kohgo T, Shindoh M (Feb 2005). "E1AF degradation by a ubiquitin-proteasome pathway". Biochemical and Biophysical Research Communications 327 (2): 575–80. doi:10.1016/j.bbrc.2004.12.045. PMID 15629152.
• Nosho K, Yoshida M, Yamamoto H, Taniguchi H, Adachi Y, Mikami M, Hinoda Y, Imai K (May 2005). "Association of Ets-related transcriptional factor E1AF expression with overexpression of matrix metalloproteinases, COX-2 and iNOS in the early stage of colorectal carcinogenesis". Carcinogenesis 26 (5): 892–9. doi:10.1093/carcin/bgi029. PMID 15695237.

External links

• ETV4 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.