ATF5

Activating transcription factor 5
Identifiers
Symbols	ATF5 ; ATFX; HMFN0395
External IDs	OMIM: 606398 MGI: 2141857 HomoloGene: 32142 GeneCards: ATF5 Gene
Gene ontology Molecular function • RNA polymerase II regulatory region sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding • transcription corepressor activity • protein binding Cellular component • nucleoplasm • transcription factor complex • cytoplasm Biological process • regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • circadian rhythm • post-embryonic development • olfactory bulb interneuron development • multicellular organism growth • negative regulation of apoptotic process • positive regulation of transcription from RNA polymerase II promoter • negative regulation of nucleic acid-templated transcription Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	22809	107503
Ensembl	ENSG00000169136	ENSMUSG00000038539
UniProt	Q9Y2D1	O70191
RefSeq (mRNA)	NM_001193646	NM_030693
RefSeq (protein)	NP_001180575	NP_109618
Location (UCSC)	Chr 19: 49.93 – 49.93 Mb	Chr 7: 44.81 – 44.82 Mb
PubMed search

Activating transcription factor 5, also known as ATF5, is a protein that, in humans, is encoded by the ATF5 gene.^[1]

Function

First described by Nishizawa and Nagata,^[2] ATF5 has been classified as a member of the activating transcription factor (ATF)/cAMP response-element binding protein (CREB) family.^[3][4]

ATF5 transcripts and protein are expressed in a wide variety of tissues, in particular, high expression of transcripts in liver. It is also present in a variety of tumor cell types.

ATF5 expression is regulated at both the transcriptional and translational level.

ATF5 is expressed in VZ and SVZ during brain development.

The human ATF5 protein is made up of 282 amino acids.

ATF5 is a transcription factor that contains a bZip domain.

See also

• Activating transcription factor

Interactions

ATF5 has been shown to interact with DISC1^[5] and TRIB3.^[6]

References

1. "Entrez Gene: ATF5 activating transcription factor 5".
2. Pati D, Meistrich ML, Plon SE (July 1999). "Human Cdc34 and Rad6B ubiquitin-conjugating enzymes target repressors of cyclic AMP-induced transcription for proteolysis". Mol. Cell. Biol. 19 (7): 5001–13. PMC 84326. PMID 10373550.
3. Hai T, Hartman MG (July 2001). "The molecular biology and nomenclature of the activating transcription factor/cAMP responsive element binding family of transcription factors: activating transcription factor proteins and homeostasis". Gene 273 (1): 1–11. doi:10.1016/S0378-1119(01)00551-0. PMID 11483355.
4. Vinson C, Myakishev M, Acharya A, Mir AA, Moll JR, Bonovich M (September 2002). "Classification of human B-ZIP proteins based on dimerization properties". Mol. Cell. Biol. 22 (18): 6321–6335. doi:10.1128/MCB.22.18.6321-6335.2002. PMC 135624. PMID 12192032.
5. Morris JA, Kandpal G, Ma L, Austin CP (Jul 2003). "DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation". Hum. Mol. Genet. 12 (13): 1591–1608. doi:10.1093/hmg/ddg162. PMID 12812986.
6. Zhou Y, Li L, Liu Q, Xing G, Kuai X, Sun J, Yin X, Wang J, Zhang L, He F (May 2008). "E3 ubiquitin ligase SIAH1 mediates ubiquitination and degradation of TRB3". Cell. Signal. 20 (5): 942–948. doi:10.1016/j.cellsig.2008.01.010. PMID 18276110.

Further reading

• Pati D, Meistrich ML, Plon SE (1999). "Human Cdc34 and Rad6B ubiquitin-conjugating enzymes target repressors of cyclic AMP-induced transcription for proteolysis". Mol. Cell. Biol. 19 (7): 5001–13. PMC 84326. PMID 10373550.
• White JH, McIllhinney RA, Wise A, Ciruela F, Chan WY, Emson PC, Billinton A, Marshall FH (2001). "The GABAB receptor interacts directly with the related transcription factors CREB2 and ATFx". Proc. Natl. Acad. Sci. U.S.A. 97 (25): 13967–13972. doi:10.1073/pnas.240452197. PMC 17684. PMID 11087824.
• Peters CS, Liang X, Li S, Kannan S, Peng Y, Taub R, Diamond RH (2001). "ATF-7, a novel bZIP protein, interacts with the PRL-1 protein-tyrosine phosphatase". J. Biol. Chem. 276 (17): 13718–26. doi:10.1074/jbc.M011562200. PMID 11278933.
• Morris JA, Kandpal G, Ma L, Austin CP (2004). "DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation". Hum. Mol. Genet. 12 (13): 1591–1608. doi:10.1093/hmg/ddg162. PMID 12812986.
• Yamada S, Ohira M, Horie H, Ando K, Takayasu H, Suzuki Y, Sugano S, Hirata T, Goto T, Matsunaga T, Hiyama E, Hayashi Y, Ando H, Suita S, Kaneko M, Sasaki F, Hashizume K, Ohnuma N, Nakagawara A (2004). "Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas". Oncogene 23 (35): 5901–5911. doi:10.1038/sj.onc.1207782. PMID 15221005.
• Liu W, Sun M, Jiang J, Shen X, Sun Q, Liu W, Shen H, Gu J (2004). "Cyclin D3 interacts with human activating transcription factor 5 and potentiates its transcription activity". Biochem. Biophys. Res. Commun. 321 (4): 954–960. doi:10.1016/j.bbrc.2004.07.053. PMID 15358120.
• Forgacs E, Gupta SK, Kerry JA, Semmes OJ (2005). "The bZIP transcription factor ATFx binds human T-cell leukemia virus type 1 (HTLV-1) Tax and represses HTLV-1 long terminal repeat-mediated transcription". J. Virol. 79 (11): 6932–6939. doi:10.1128/JVI.79.11.6932-6939.2005. PMC 1112100. PMID 15890932.
• Al Sarraj J, Vinson C, Thiel G (2005). "Regulation of asparagine synthetase gene transcription by the basic region leucine zipper transcription factors ATF5 and CHOP". Biol. Chem. 386 (9): 873–879. doi:10.1515/BC.2005.102. PMID 16164412.
• Angelastro JM, Canoll PD, Kuo J, Weicker M, Costa A, Bruce JN, Greene LA (2006). "Selective destruction of glioblastoma cells by interference with the activity or expression of ATF5". Oncogene 25 (6): 907–916. doi:10.1038/sj.onc.1209116. PMID 16170340.
• Wei Y, Jiang J, Sun M, Chen X, Wang H, Gu J (2006). "ATF5 increases cisplatin-induced apoptosis through up-regulation of cyclin D3 transcription in HeLa cells". Biochem. Biophys. Res. Commun. 339 (2): 591–596. doi:10.1016/j.bbrc.2005.11.054. PMID 16300731.
• Kakiuchi C, Ishiwata M, Nanko S, Kunugi H, Minabe Y, Nakamura K, Mori N, Fujii K, Yamada K, Yoshikawa T, Kato T (2007). "Association analysis of ATF4 and ATF5, genes for interacting-proteins of DISC1, in bipolar disorder". Neurosci. Lett. 417 (3): 316–321. doi:10.1016/j.neulet.2007.02.054. PMID 17346882.
• Watatani Y, Ichikawa K, Nakanishi N, Fujimoto M, Takeda H, Kimura N, Hirose H, Takahashi S, Takahashi Y (2008). "Stress-induced translation of ATF5 mRNA is regulated by the 5'-untranslated region". J. Biol. Chem. 283 (5): 2543–2553. doi:10.1074/jbc.M707781200. PMID 18055463.

External links

• ATF5 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.