SIX2

SIX homeobox 2
Identifiers
Symbol	SIX2
External IDs	OMIM: 604994 MGI: 102778 HomoloGene: 56518 GeneCards: SIX2 Gene
Gene ontology Molecular function • RNA polymerase II core promoter proximal region sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • transcription factor activity, sequence-specific DNA binding • transcription factor binding • protein complex binding Cellular component • nucleus • nucleoplasm • cytoplasm • plasma membrane • nuclear membrane Biological process • kidney development • chondrocyte differentiation • mesenchymal to epithelial transition involved in metanephros morphogenesis • transcription from RNA polymerase II promoter • protein import into nucleus • mesodermal cell fate specification • cell proliferation • anatomical structure morphogenesis • anterior/posterior axis specification • cell migration • regulation of ossification • regulation of chondrocyte differentiation • middle ear morphogenesis • positive regulation of transcription from RNA polymerase II promoter • embryonic digestive tract morphogenesis • embryonic cranial skeleton morphogenesis • nephron development • nephron morphogenesis • mesenchymal stem cell maintenance involved in nephron morphogenesis • mesenchymal cell differentiation involved in kidney development • regulation of branching involved in ureteric bud morphogenesis • mesenchymal stem cell proliferation • positive regulation of chondrocyte proliferation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10736	20472
Ensembl	ENSG00000170577	ENSMUSG00000024134
UniProt	Q9NPC8	Q62232
RefSeq (mRNA)	NM_016932	NM_011380
RefSeq (protein)	NP_058628	NP_035510
Location (UCSC)	Chr 2: 45.01 – 45.01 Mb	Chr 17: 85.68 – 85.69 Mb
PubMed search

Homeobox protein SIX2 is a protein that in humans is encoded by the SIX2 gene.^[1][2]

References

1. "Entrez Gene: SIX2 sine oculis homeobox homolog 2 (Drosophila)".
2. Oliver, Guillermo (1995). "Homeobox genes and connective tissue patterning" (PDF). Development 121: 693-705. PMID 7720577.

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• López-Ríos J, Tessmar K, Loosli F, et al. (2003). "Six3 and Six6 activity is modulated by members of the groucho family.". Development 130 (1): 185–95. doi:10.1242/dev.00185. PMID 12441302.
• Ikeda K, Watanabe Y, Ohto H, Kawakami K (2002). "Molecular interaction and synergistic activation of a promoter by Six, Eya, and Dach proteins mediated through CREB binding protein.". Mol. Cell. Biol. 22 (19): 6759–66. doi:10.1128/MCB.22.19.6759-6766.2002. PMC 134036. PMID 12215533.
• Buller C, Xu X, Marquis V, et al. (2002). "Molecular effects of Eya1 domain mutations causing organ defects in BOR syndrome.". Hum. Mol. Genet. 10 (24): 2775–81. doi:10.1093/hmg/10.24.2775. PMID 11734542.
• Boucher CA, Winchester CL, Hamilton GM, et al. (2000). "Structure, mapping and expression of the human gene encoding the homeodomain protein, SIX2.". Gene 247 (1–2): 145–51. doi:10.1016/S0378-1119(00)00105-0. PMID 10773454.
• Celli J, van Beusekom E, Hennekam RC, et al. (2000). "Familial syndromic esophageal atresia maps to 2p23-p24". Am. J. Hum. Genet. 66 (2): 436–44. doi:10.1086/302779. PMC 1288096. PMID 10677303.
• Kawakami K, Ohto H, Takizawa T, Saito T (1996). "Identification and expression of six family genes in mouse retina". FEBS Lett. 393 (2–3): 259–63. doi:10.1016/0014-5793(96)00899-X. PMID 8814301.