NFATC3

Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2XRW​, 2XS0​
Identifiers
Symbols	NFATC3 ; NFAT4; NFATX
External IDs	OMIM: 602698 MGI: 103296 HomoloGene: 27827 GeneCards: NFATC3 Gene
Gene ontology Molecular function • RNA polymerase II core promoter proximal region sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • chromatin binding • protein binding • transcription factor binding Cellular component • nucleus • nucleoplasm • nucleolus • cytoplasm • cytosol Biological process • patterning of blood vessels • response to hypoxia • blood vessel remodeling • stimulatory C-type lectin receptor signaling pathway • regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • inflammatory response • heart development • cardiac muscle hypertrophy in response to stress • T cell differentiation • calcineurin-NFAT signaling cascade • Fc-epsilon receptor signaling pathway • innate immune response • cellular respiration • positive regulation of transcription from RNA polymerase II promoter • thymus development • skeletal muscle fiber development • smooth muscle cell differentiation • cellular response to calcium ion • cellular response to lithium ion • regulation of store-operated calcium entry Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4775	18021
Ensembl	ENSG00000072736	ENSMUSG00000031902
UniProt	Q12968	B5B2U1
RefSeq (mRNA)	NM_004555	NM_010901
RefSeq (protein)	NP_004546	NP_035031
Location (UCSC)	Chr 16: 68.08 – 68.23 Mb	Chr 8: 106.06 – 106.13 Mb
PubMed search

Nuclear factor of activated T-cells, cytoplasmic 3 is a protein that in humans is encoded by the NFATC3 gene.^[1][2]

Function

The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family participate to form this complex also. The product of this gene plays a role in the regulation of gene expression in T cells and immature thymocytes. Four transcript variants encoding distinct isoforms have been identified for this gene.^[2]

See also

• NFAT

References

1. Hoey T, Sun YL, Williamson K, Xu X (May 1995). "Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins". Immunity 2 (5): 461–72. doi:10.1016/1074-7613(95)90027-6. PMID 7749981.
2. "Entrez Gene: NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3".

Further reading

• Rao A, Luo C, Hogan PG (1997). "Transcription factors of the NFAT family: regulation and function". Annual Review of Immunology 15: 707–47. doi:10.1146/annurev.immunol.15.1.707. PMID 9143705.
• Crabtree GR (Mar 1999). "Generic signals and specific outcomes: signaling through Ca2+, calcineurin, and NF-AT". Cell 96 (5): 611–4. doi:10.1016/S0092-8674(00)80571-1. PMID 10089876.
• Horsley V, Pavlath GK (Mar 2002). "NFAT: ubiquitous regulator of cell differentiation and adaptation". The Journal of Cell Biology 156 (5): 771–4. doi:10.1083/jcb.200111073. PMC 2173310. PMID 11877454.
• Masuda ES, Naito Y, Tokumitsu H, Campbell D, Saito F, Hannum C, Arai K, Arai N (May 1995). "NFATx, a novel member of the nuclear factor of activated T cells family that is expressed predominantly in the thymus". Molecular and Cellular Biology 15 (5): 2697–706. doi:10.1128/mcb.15.5.2697. PMC 230500. PMID 7739550.
• Jabado N, Le Deist F, Fisher A, Hivroz C (Nov 1994). "Interaction of HIV gp120 and anti-CD4 antibodies with the CD4 molecule on human CD4+ T cells inhibits the binding activity of NF-AT, NF-kappa B and AP-1, three nuclear factors regulating interleukin-2 gene enhancer activity". European Journal of Immunology 24 (11): 2646–52. doi:10.1002/eji.1830241112. PMID 7957556.
• Vacca A, Farina M, Maroder M, Alesse E, Screpanti I, Frati L, Gulino A (Nov 1994). "Human immunodeficiency virus type-1 tat enhances interleukin-2 promoter activity through synergism with phorbol ester and calcium-mediated activation of the NF-AT cis-regulatory motif". Biochemical and Biophysical Research Communications 205 (1): 467–74. doi:10.1006/bbrc.1994.2689. PMID 7999066.
• Di Somma MM, Majolini MB, Burastero SE, Telford JL, Baldari CT (Sep 1996). "Cyclosporin A sensitivity of the HIV-1 long terminal repeat identifies distinct p56lck-dependent pathways activated by CD4 triggering". European Journal of Immunology 26 (9): 2181–8. doi:10.1002/eji.1830260933. PMID 8814265.
• Masuda ES, Liu J, Imamura R, Imai SI, Arai KI, Arai N (Apr 1997). "Control of NFATx1 nuclear translocation by a calcineurin-regulated inhibitory domain". Molecular and Cellular Biology 17 (4): 2066–75. doi:10.1128/mcb.17.4.2066. PMC 232054. PMID 9121455.
• Chow CW, Rincón M, Cavanagh J, Dickens M, Davis RJ (Nov 1997). "Nuclear accumulation of NFAT4 opposed by the JNK signal transduction pathway". Science 278 (5343): 1638–41. doi:10.1126/science.278.5343.1638. PMID 9374467.
• Amasaki Y, Masuda ES, Imamura R, Arai K, Arai N (Mar 1998). "Distinct NFAT family proteins are involved in the nuclear NFAT-DNA binding complexes from human thymocyte subsets". Journal of Immunology 160 (5): 2324–33. PMID 9498773.
• Zhu J, Shibasaki F, Price R, Guillemot JC, Yano T, Dötsch V, Wagner G, Ferrara P, McKeon F (May 1998). "Intramolecular masking of nuclear import signal on NF-AT4 by casein kinase I and MEKK1". Cell 93 (5): 851–61. doi:10.1016/S0092-8674(00)81445-2. PMID 9630228.
• Aramburu J, Garcia-Cózar F, Raghavan A, Okamura H, Rao A, Hogan PG (Apr 1998). "Selective inhibition of NFAT activation by a peptide spanning the calcineurin targeting site of NFAT". Molecular Cell 1 (5): 627–37. doi:10.1016/S1097-2765(00)80063-5. PMID 9660947.
• Imamura R, Masuda ES, Naito Y, Imai S, Fujino T, Takano T, Arai K, Arai N (Oct 1998). "Carboxyl-terminal 15-amino acid sequence of NFATx1 is possibly created by tissue-specific splicing and is essential for transactivation activity in T cells". Journal of Immunology 161 (7): 3455–63. PMID 9759864.
• Loftus BJ, Kim UJ, Sneddon VP, Kalush F, Brandon R, Fuhrmann J, Mason T, Crosby ML, Barnstead M, Cronin L, Deslattes Mays A, Cao Y, Xu RX, Kang HL, Mitchell S, Eichler EE, Harris PC, Venter JC, Adams MD (Sep 1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q". Genomics 60 (3): 295–308. doi:10.1006/geno.1999.5927. PMID 10493829.
• Amasaki Y, Adachi S, Ishida Y, Iwata M, Arai N, Arai K, Miyatake S (Jul 2002). "A constitutively nuclear form of NFATx shows efficient transactivation activity and induces differentiation of CD4(+)CD8(+) T cells". The Journal of Biological Chemistry 277 (28): 25640–8. doi:10.1074/jbc.M201860200. PMID 11997392.
• Chagnon P, Michaud J, Mitchell G, Mercier J, Marion JF, Drouin E, Rasquin-Weber A, Hudson TJ, Richter A (Dec 2002). "A missense mutation (R565W) in cirhin (FLJ14728) in North American Indian childhood cirrhosis". American Journal of Human Genetics 71 (6): 1443–9. doi:10.1086/344580. PMC 378590. PMID 12417987.

External links

• NFATC3 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.