ZNF423

Zinc finger protein 423
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2MDG​
Identifiers
Symbols	ZNF423 ; Ebfaz; JBTS19; NPHP14; OAZ; Roaz; ZFP423; Zfp104; hOAZ
External IDs	OMIM: 604557 MGI: 1891217 HomoloGene: 9010 GeneCards: ZNF423 Gene
Gene ontology Molecular function • DNA binding • protein binding • metal ion binding Cellular component • nucleus Biological process • transcription, DNA-templated • Notch signaling pathway • nervous system development • cell differentiation • positive regulation of BMP signaling pathway • negative regulation of transcription, DNA-templated • positive regulation of transcription, DNA-templated Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23090	94187
Ensembl	ENSG00000102935	ENSMUSG00000045333
UniProt	Q2M1K9	Q80TS5
RefSeq (mRNA)	NM_001271620	NM_033327
RefSeq (protein)	NP_001258549	NP_201584
Location (UCSC)	Chr 16: 49.49 – 49.86 Mb	Chr 8: 87.66 – 87.96 Mb
PubMed search

Zinc finger protein 423 is a protein that in humans is encoded by the ZNF423 gene.^[1][2][3]

The protein encoded by this gene is a nuclear protein that belongs to the family of Kruppel-like C2H2 zinc finger proteins. It functions as a DNA-binding transcription factor by using distinct zinc fingers in different signaling pathways. Thus, it is thought that this gene may have multiple roles in signal transduction during development.^[3]

Interactions

ZNF423 has been shown to interact with EBF1^[4] and PARP1.^[5]

References

1. Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Apr 1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
2. Hata A, Seoane J, Lagna G, Montalvo E, Hemmati-Brivanlou A, Massague J (Feb 2000). "OAZ uses distinct DNA- and protein-binding zinc fingers in separate BMP-Smad and Olf signaling pathways". Cell 100 (2): 229–40. doi:10.1016/S0092-8674(00)81561-5. PMID 10660046.
3. "Entrez Gene: ZNF423 zinc finger protein 423".
4. Tsai, R Y; Reed R R (Jun 1997). "Cloning and functional characterization of Roaz, a zinc finger protein that interacts with O/E-1 to regulate gene expression: implications for olfactory neuronal development". J. Neurosci. (UNITED STATES) 17 (11): 4159–69. ISSN 0270-6474. PMID 9151733.
5. Ku, Man-ching; Stewart Shavonne; Hata Akiko (Nov 2003). "Poly(ADP-ribose) polymerase 1 interacts with OAZ and regulates BMP-target genes". Biochem. Biophys. Res. Commun. (United States) 311 (3): 702–7. doi:10.1016/j.bbrc.2003.10.053. ISSN 0006-291X. PMID 14623329.

Further reading

• Warming S, Rachel RA, Jenkins NA, Copeland NG. (2006). "Zfp423 Is Required for Normal Cerebellar Development". Mol Cell Biol. 26 (18): 6913–22. doi:10.1128/MCB.02255-05. PMC 1592861. PMID 16943432.
• Alcaraz WA; Gold DA; Raponi E; et al. (2006). "Zfp423 controls proliferation and differentiation of neural precursors in cerebellar vermis formation". Proc Natl Acad Sci U S A. 103 (51): 19424–9. doi:10.1073/pnas.0609184103. PMC 1748242. PMID 17151198.
• Cheng LE, Reed RR. (2007). "Zfp423/OAZ participates in a developmental switch during olfactory neurogenesis". Neuron 54 (4): 547–57. doi:10.1016/j.neuron.2007.04.029. PMC 2866517. PMID 17521568.
• Cheng LE, Zhang J, Reed RR (2007). "The transcription factor Zfp423/OAZ is required for cerebellar development and CNS midline patterning". Dev Biol. 307 (1): 43–52. doi:10.1016/j.ydbio.2007.04.005. PMC 2866529. PMID 17524391.

• Ota T; Suzuki Y; Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Ku MC, Stewart S, Hata A (2004). "Poly(ADP-ribose) polymerase 1 interacts with OAZ and regulates BMP-target genes". Biochem. Biophys. Res. Commun. 311 (3): 702–7. doi:10.1016/j.bbrc.2003.10.053. PMID 14623329.
• Strausberg RL; Feingold EA; Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Shim S, Bae N, Han JK (2002). "Bone morphogenetic protein-4-induced activation of Xretpos is mediated by Smads and Olf-1/EBF associated zinc finger (OAZ)". Nucleic Acids Res. 30 (14): 3107–17. doi:10.1093/nar/gkf437. PMC 135757. PMID 12136093.
• Tsai RY, Reed RR (1997). "Cloning and functional characterization of Roaz, a zinc finger protein that interacts with O/E-1 to regulate gene expression: implications for olfactory neuronal development". J. Neurosci. 17 (11): 4159–69. PMID 9151733.
• Robertson NG; Khetarpal U; Gutiérrez-Espeleta GA; et al. (1995). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening". Genomics 23 (1): 42–50. doi:10.1006/geno.1994.1457. PMID 7829101.

External links

• OAZ protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.