NFIA

Nuclear factor I/A
Identifiers
Symbols	NFIA ; CTF; NF-I/A; NF1-A; NFI-A; NFI-L
External IDs	OMIM: 600727 MGI: 108056 HomoloGene: 4086 GeneCards: NFIA Gene
Gene ontology Molecular function • RNA polymerase II core promoter proximal region sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • chromatin binding • transcription factor activity, sequence-specific DNA binding • transcription factor binding Cellular component • nucleus • nucleoplasm • cell junction Biological process • negative regulation of transcription from RNA polymerase II promoter • DNA replication • regulation of transcription, DNA-templated • transcription from RNA polymerase II promoter • viral genome replication • positive regulation of transcription from RNA polymerase II promoter • synapse maturation Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4774	18027
Ensembl	ENSG00000162599	ENSMUSG00000028565
UniProt	Q12857	Q02780
RefSeq (mRNA)	NM_001134673	NM_001122952
RefSeq (protein)	NP_001128145	NP_001116424
Location (UCSC)	Chr 1: 60.87 – 61.46 Mb	Chr 4: 97.77 – 98.12 Mb
PubMed search

Nuclear factor 1 A-type is a protein that in humans is encoded by the NFIA gene.^[1][2]

Nuclear factor I (NFI) proteins constitute a family of dimeric DNA-binding proteins with similar, and possibly identical, DNA-binding specificity. They function as cellular transcription factors and as replication factors for adenovirus DNA replication. Diversity in this protein family is generated by multiple genes, differential splicing, and heterodimerization.[supplied by OMIM]^[2]

References

1. Qian F, Kruse U, Lichter P, Sippel AE (Dec 1995). "Chromosomal localization of the four genes (NFIA, B, C, and X) for the human transcription factor nuclear factor I by FISH". Genomics 28 (1): 66–73. doi:10.1006/geno.1995.1107. PMID 7590749.
2. "Entrez Gene: NFIA nuclear factor I/A".

Further reading

• Leahy P, Crawford DR, Grossman G, et al. (1999). "CREB binding protein coordinates the function of multiple transcription factors including nuclear factor I to regulate phosphoenolpyruvate carboxykinase (GTP) gene transcription.". J. Biol. Chem. 274 (13): 8813–22. doi:10.1074/jbc.274.13.8813. PMID 10085123.
• das Neves L, Duchala CS, Tolentino-Silva F, et al. (1999). "Disruption of the murine nuclear factor I-A gene (Nfia) results in perinatal lethality, hydrocephalus, and agenesis of the corpus callosum.". Proc. Natl. Acad. Sci. U.S.A. 96 (21): 11946–51. doi:10.1073/pnas.96.21.11946. PMC 18392. PMID 10518556.
• Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Xu H, Uno JK, Inouye M, et al. (2005). "NF1 transcriptional factor(s) is required for basal promoter activation of the human intestinal NaPi-IIb cotransporter gene.". Am. J. Physiol. Gastrointest. Liver Physiol. 288 (2): G175–81. doi:10.1152/ajpgi.00396.2004. PMID 15458926.
• Wang W, Stock RE, Gronostajski RM, et al. (2005). "A role for nuclear factor I in the intrinsic control of cerebellar granule neuron gene expression.". J. Biol. Chem. 279 (51): 53491–7. doi:10.1074/jbc.M410370200. PMID 15466411.
• Champ PC, Maurice S, Vargason JM, et al. (2005). "Distributions of Z-DNA and nuclear factor I in human chromosome 22: a model for coupled transcriptional regulation.". Nucleic Acids Res. 32 (22): 6501–10. doi:10.1093/nar/gkh988. PMC 545456. PMID 15598822.
• Berry FB, O'Neill MA, Coca-Prados M, Walter MA (2005). "FOXC1 transcriptional regulatory activity is impaired by PBX1 in a filamin A-mediated manner.". Mol. Cell. Biol. 25 (4): 1415–24. doi:10.1128/MCB.25.4.1415-1424.2005. PMC 548007. PMID 15684392.
• Fazi F, Rosa A, Fatica A, et al. (2006). "A minicircuitry composed of microRNA-223 and transcription factors NFI-A and C/EBPalpha regulates human granulopoiesis.". Cell 123 (5): 819–31. doi:10.1016/j.cell.2005.09.023. PMID 16325577.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
• Lin YL, Wang YH, Lee HJ (2006). "Transcriptional regulation of the human TR2 orphan receptor gene by nuclear factor 1-A.". Biochem. Biophys. Res. Commun. 350 (2): 430–6. doi:10.1016/j.bbrc.2006.09.061. PMID 17010934.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Lu W, Quintero-Rivera F, Fan Y, et al. (2007). "NFIA haploinsufficiency is associated with a CNS malformation syndrome and urinary tract defects.". PLoS Genet. 3 (5): e80. doi:10.1371/journal.pgen.0030080. PMC 1877820. PMID 17530927.

External links

• NFIA protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.