PBX3

Pre-B-cell leukemia homeobox 3
Cartoon diagram of a HOXB1–PBX1 heterodimer (violet) binding a DNA fragment (blue). Rendering based on PDB 1b72.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1b72​, 1b8i​, 1du6​, 1lfu​, 1puf​
Identifiers
Symbol	PBX3
External IDs	OMIM: 176312 MGI: 97496 HomoloGene: 21243 GeneCards: PBX3 Gene
Gene ontology Molecular function • RNA polymerase II distal enhancer sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding Cellular component • nucleus • transcription factor complex Biological process • regulation of respiratory gaseous exchange by neurological system process • transcription from RNA polymerase II promoter • anterior compartment pattern formation • posterior compartment specification • respiratory gaseous exchange • adult locomotory behavior • dorsal spinal cord development • positive regulation of transcription from RNA polymerase II promoter • neuron development Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5090	18516
Ensembl	ENSG00000167081	ENSMUSG00000038718
UniProt	P40426	O35317
RefSeq (mRNA)	NM_001134778	NM_001290576
RefSeq (protein)	NP_001128250	NP_001277505
Location (UCSC)	Chr 9: 125.75 – 125.97 Mb	Chr 2: 34.17 – 34.37 Mb
PubMed search

Pre-B-cell leukemia transcription factor 3 is a protein that in humans is encoded by the PBX3 gene.^[1][2]

References

1. Monica K, Galili N, Nourse J, Saltman D, Cleary ML (Dec 1991). "PBX2 and PBX3, new homeobox genes with extensive homology to the human proto-oncogene PBX1". Mol Cell Biol 11 (12): 6149–57. PMC 361792. PMID 1682799.
2. "Entrez Gene: PBX3 pre-B-cell leukemia homeobox 3".

Further reading

• Lu Q, Wright DD, Kamps MP (1994). "Fusion with E2A converts the Pbx1 homeodomain protein into a constitutive transcriptional activator in human leukemias carrying the t(1;19) translocation". Mol. Cell. Biol. 14 (6): 3938–48. PMC 358760. PMID 7910944.
• Shen WF, Rozenfeld S, Kwong A, et al. (1999). "HOXA9 Forms Triple Complexes with PBX2 and MEIS1 in Myeloid Cells". Mol. Cell. Biol. 19 (4): 3051–61. PMC 84099. PMID 10082572.
• Fujino T, Yamazaki Y, Largaespada DA, et al. (2001). "Inhibition of myeloid differentiation by Hoxa9, Hoxb8, and Meis homeobox genes". Exp. Hematol. 29 (7): 856–63. doi:10.1016/S0301-472X(01)00655-5. PMID 11438208.
• Knoepfler PS, Sykes DB, Pasillas M, Kamps MP (2001). "HoxB8 requires its Pbx-interaction motif to block differentiation of primary myeloid progenitors and of most cell line models of myeloid differentiation". Oncogene 20 (39): 5440–8. doi:10.1038/sj.onc.1204710. PMID 11571641.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
• Rhee JW, Arata A, Selleri L, et al. (2004). "Pbx3 Deficiency Results in Central Hypoventilation". Am. J. Pathol. 165 (4): 1343–50. doi:10.1016/S0002-9440(10)63392-5. PMC 1618620. PMID 15466398.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

External links

• PBX3 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
• FactorBook Pbx3

This article incorporates text from the United States National Library of Medicine, which is in the public domain.