KLF10

Kruppel-like factor 10
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2EPA​
Identifiers
Symbols	KLF10 ; EGR-alpha; EGRA; TIEG; TIEG1
External IDs	OMIM: 601878 MGI: 1101353 HomoloGene: 4135 GeneCards: KLF10 Gene
Gene ontology Molecular function • core promoter sequence-specific DNA binding • transcription factor activity, sequence-specific DNA binding • protein binding • metal ion binding Cellular component • nucleus Biological process • negative regulation of transcription from RNA polymerase II promoter • skeletal system development • transcription, DNA-templated • transforming growth factor beta receptor signaling pathway • cell-cell signaling • circadian rhythm • cell proliferation • negative regulation of cell proliferation • cellular response to starvation • bone mineralization • somatic stem cell maintenance • regulation of circadian rhythm • positive regulation of osteoclast differentiation • negative regulation of transcription, DNA-templated • cellular response to peptide Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7071	21847
Ensembl	ENSG00000155090	ENSMUSG00000037465
UniProt	Q13118	O89091
RefSeq (mRNA)	NM_001032282	NM_001289471
RefSeq (protein)	NP_001027453	NP_001276400
Location (UCSC)	Chr 8: 102.65 – 102.66 Mb	Chr 15: 38.29 – 38.3 Mb
PubMed search

Krueppel-like factor 10 is a protein that in humans is encoded by the KLF10 gene.^[1][2][3]

See also

• Kruppel-like factors

References

1. Blok LJ, Grossmann ME, Perry JE, Tindall DJ (Mar 1996). "Characterization of an early growth response gene, which encodes a zinc finger transcription factor, potentially involved in cell cycle regulation". Mol Endocrinol 9 (11): 1610–20. doi:10.1210/me.9.11.1610. PMID 8584037.
2. Fautsch MP, Vrabel A, Subramaniam M, Hefferen TE, Spelsberg TC, Wieben ED (Oct 1998). "TGFbeta-inducible early gene (TIEG) also codes for early growth response alpha (EGRalpha): evidence of multiple transcripts from alternate promoters". Genomics 51 (3): 408–16. doi:10.1006/geno.1998.5388. PMID 9721211.
3. "Entrez Gene: KLF10 Kruppel-like factor 10".

Further reading

• Subramaniam M, Harris SA, Oursler MJ, et al. (1996). "Identification of a novel TGF-beta-regulated gene encoding a putative zinc finger protein in human osteoblasts.". Nucleic Acids Res. 23 (23): 4907–12. doi:10.1093/nar/23.23.4907. PMC 307482. PMID 8532536.
• Tachibana I, Imoto M, Adjei PN, et al. (1997). "Overexpression of the TGFbeta-regulated zinc finger encoding gene, TIEG, induces apoptosis in pancreatic epithelial cells.". J. Clin. Invest. 99 (10): 2365–74. doi:10.1172/JCI119418. PMC 508075. PMID 9153278.
• Subramaniam M, Hefferan TE, Tau K, et al. (1998). "Tissue, cell type, and breast cancer stage-specific expression of a TGF-beta inducible early transcription factor gene.". J. Cell. Biochem. 68 (2): 226–36. doi:10.1002/(SICI)1097-4644(19980201)68:2<226::AID-JCB9>3.0.CO;2-X. PMID 9443078.
• Cook T, Gebelein B, Mesa K, et al. (1998). "Molecular cloning and characterization of TIEG2 reveals a new subfamily of transforming growth factor-beta-inducible Sp1-like zinc finger-encoding genes involved in the regulation of cell growth.". J. Biol. Chem. 273 (40): 25929–36. doi:10.1074/jbc.273.40.25929. PMID 9748269.
• Hefferan TE, Reinholz GG, Rickard DJ, et al. (2000). "Overexpression of a nuclear protein, TIEG, mimics transforming growth factor-beta action in human osteoblast cells.". J. Biol. Chem. 275 (27): 20255–9. doi:10.1074/jbc.C000135200. PMID 10816551.
• Gunther M, Laithier M, Brison O (2000). "A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening.". Mol. Cell. Biochem. 210 (1-2): 131–42. doi:10.1023/A:1007177623283. PMID 10976766.
• Antonello D, Moore PS, Zamboni G, et al. (2002). "Absence of mutations in the transforming growth factor-beta inducible early gene 1, TIEG1, in pancreatic cancer.". Cancer Lett. 183 (2): 179–83. doi:10.1016/S0304-3835(01)00802-3. PMID 12065093.
• Johnsen SA, Subramaniam M, Monroe DG, et al. (2002). "Modulation of transforming growth factor beta (TGFbeta)/Smad transcriptional responses through targeted degradation of TGFbeta-inducible early gene-1 by human seven in absentia homologue.". J. Biol. Chem. 277 (34): 30754–9. doi:10.1074/jbc.M204812200. PMID 12072443.
• Johnsen SA, Subramaniam M, Janknecht R, Spelsberg TC (2002). "TGFbeta inducible early gene enhances TGFbeta/Smad-dependent transcriptional responses.". Oncogene 21 (37): 5783–90. doi:10.1038/sj.onc.1205681. PMID 12173049.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Chrisman HR, Tindall DJ (2003). "Identification and characterization of a consensus DNA binding element for the zinc finger transcription factor TIEG/EGRalpha.". DNA Cell Biol. 22 (3): 187–99. doi:10.1089/104454903321655819. PMID 12804117.
• Noti JD, Johnson AK, Dillon JD (2004). "The zinc finger transcription factor transforming growth factor beta-inducible early gene-1 confers myeloid-specific activation of the leukocyte integrin CD11d promoter.". J. Biol. Chem. 279 (26): 26948–58. doi:10.1074/jbc.M310634200. PMID 15087465.
• Reinholz MM, An MW, Johnsen SA, et al. (2004). "Differential gene expression of TGF beta inducible early gene (TIEG), Smad7, Smad2 and Bard1 in normal and malignant breast tissue.". Breast Cancer Res. Treat. 86 (1): 75–88. doi:10.1023/B:BREA.0000032926.74216.7d. PMID 15218362.
• Johnsen SA, Subramaniam M, Effenberger KE, and Spelsberg TC (2004). "The TGFβ Inducible Early Gene Plays a Central Role in the Anti-Proliferative Response to TGFβ.". Signal Transduction 4: 29–35. doi:10.1002/sita.200400032.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Subramaniam M, Gorny G, Johnsen SA, Monroe DG, Evans GL, Fraser DG, Rickard DJ, Rasmussen K, van Deursen JMA, Turner RT, Oursler MJ, and Spelsberg TC (2005). "TIEG1 Null Mouse-Derived Osteoblasts Are Defective in Mineralization and in Support of Osteoclast Differentiation In Vitro.". Mol. Cell. Biol. 25 (3): 1191–1199. doi:10.1128/MCB.25.3.1191-1199.2005. PMC 543998. PMID 15657444.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
• Fueki N, Sagara H, Akimoto K, et al. (2007). "Interleukin-10 regulates transforming growth factor-beta signaling in cultured human bronchial epithelial cells.". Respiration; international review of thoracic diseases 74 (4): 454–9. doi:10.1159/000101057. PMID 17377371.
• Jin W, Di G, Li J, et al. (2007). "TIEG1 induces apoptosis through mitochondrial apoptotic pathway and promotes apoptosis induced by homoharringtonine and velcade.". FEBS Lett. 581 (20): 3826–32. doi:10.1016/j.febslet.2007.07.008. PMID 17659279.
• Subramaniam M, Hawse JR, Johnsen SA, and Spelsberg TC (2007). "TIEG1: An Important Regulator of Multiple Biological Processes and Disease States.". J. Cell. Biochem. 102 (3): 539–548. doi:10.1002/jcb.21492. PMID 17729309.

External links

• KLF10 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.