ZNF10
| Zinc finger protein 10 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | ZNF10 ; KOX1 | ||||||||||||
| External IDs | OMIM: 194538 HomoloGene: 130674 GeneCards: ZNF10 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 7556 | n/a | |||||||||||
| Ensembl | ENSG00000256223 | n/a | |||||||||||
| UniProt | P21506 | n/a | |||||||||||
| RefSeq (mRNA) | NM_015394 | n/a | |||||||||||
| RefSeq (protein) | NP_056209 | n/a | |||||||||||
| Location (UCSC) |
Chr 12: 133.13 – 133.16 Mb | n/a | |||||||||||
| PubMed search | n/a | ||||||||||||
Zinc finger protein 10 is a protein that in humans is encoded by the ZNF10 gene.[1][2][3]
Function
The protein encoded by this gene contains a C2H2 zinc finger, and has been shown to function as a transcriptional repressor. The Kruppel-associated box (KRAB) domain of this protein is found to be responsible for its transcriptional repression activity. RING finger containing protein TIF1 was reported to interact with the KRAB domain, and may serve as a mediator for the repression activity of this protein.[3]
Interactions
ZNF10 has been shown to interact with TRIM28.[4][5]
References
- ↑ Abrink M, Aveskogh M, Hellman L (Feb 1995). "Isolation of cDNA clones for 42 different Krüppel-related zinc finger proteins expressed in the human monoblast cell line U-937". DNA and Cell Biology 14 (2): 125–36. doi:10.1089/dna.1995.14.125. PMID 7865130.
- ↑ Rousseau-Merck MF, Hillion J, Jonveaux P, Couillin P, Seité P, Thiesen HJ, Berger R (Dec 1993). "Chromosomal localization of 9 KOX zinc finger genes: physical linkages suggest clustering of KOX genes on chromosomes 12, 16, and 19". Human Genetics 92 (6): 583–7. doi:10.1007/BF00420943. PMID 8262519.
- 1 2 "Entrez Gene: ZNF10 zinc finger protein 10".
- ↑ Moosmann P, Georgiev O, Le Douarin B, Bourquin JP, Schaffner W (Dec 1996). "Transcriptional repression by RING finger protein TIF1 beta that interacts with the KRAB repressor domain of KOX1". Nucleic Acids Research 24 (24): 4859–67. doi:10.1093/nar/24.24.4859. PMC 146346. PMID 9016654.
- ↑ Peng H, Begg GE, Harper SL, Friedman JR, Speicher DW, Rauscher FJ (Jun 2000). "Biochemical analysis of the Kruppel-associated box (KRAB) transcriptional repression domain". The Journal of Biological Chemistry 275 (24): 18000–10. doi:10.1074/jbc.M001499200. PMID 10748030.
Further reading
- Huebner K, Druck T, Croce CM, Thiesen HJ (Apr 1991). "Twenty-seven nonoverlapping zinc finger cDNAs from human T cells map to nine different chromosomes with apparent clustering". American Journal of Human Genetics 48 (4): 726–40. PMC 1682948. PMID 2014798.
- Thiesen HJ (Apr 1990). "Multiple genes encoding zinc finger domains are expressed in human T cells". The New Biologist 2 (4): 363–74. PMID 2288909.
- Vissing H, Meyer WK, Aagaard L, Tommerup N, Thiesen HJ (Aug 1995). "Repression of transcriptional activity by heterologous KRAB domains present in zinc finger proteins". FEBS Letters 369 (2-3): 153–7. doi:10.1016/0014-5793(95)00728-R. PMID 7649249.
- Moosmann P, Georgiev O, Le Douarin B, Bourquin JP, Schaffner W (Dec 1996). "Transcriptional repression by RING finger protein TIF1 beta that interacts with the KRAB repressor domain of KOX1". Nucleic Acids Research 24 (24): 4859–67. doi:10.1093/nar/24.24.4859. PMC 146346. PMID 9016654.
- Moosmann P, Georgiev O, Thiesen HJ, Hagmann M, Schaffner W (Jul 1997). "Silencing of RNA polymerases II and III-dependent transcription by the KRAB protein domain of KOX1, a Krüppel-type zinc finger factor". Biological Chemistry 378 (7): 669–77. doi:10.1515/bchm.1997.378.7.669. PMID 9278146.
- Peng H, Begg GE, Harper SL, Friedman JR, Speicher DW, Rauscher FJ (Jun 2000). "Biochemical analysis of the Kruppel-associated box (KRAB) transcriptional repression domain". The Journal of Biological Chemistry 275 (24): 18000–10. doi:10.1074/jbc.M001499200. PMID 10748030.
- Lorenz P, Koczan D, Thiesen HJ (Apr 2001). "Transcriptional repression mediated by the KRAB domain of the human C2H2 zinc finger protein Kox1/ZNF10 does not require histone deacetylation". Biological Chemistry 382 (4): 637–44. doi:10.1515/BC.2001.075. PMID 11405226.
External links
- ZNF10 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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