HSF2

Heat shock transcription factor 2
Identifiers
Symbols HSF2 ; HSF 2; HSTF 2
External IDs OMIM: 140581 MGI: 96239 HomoloGene: 37931 GeneCards: HSF2 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 3298 15500
Ensembl ENSG00000025156 ENSMUSG00000019878
UniProt Q03933 P38533
RefSeq (mRNA) NM_001135564 NM_008297
RefSeq (protein) NP_001129036 NP_032323
Location (UCSC) Chr 6:
122.4 – 122.43 Mb
Chr 10:
57.49 – 57.51 Mb
PubMed search

Heat shock factor protein 2 is a protein that in humans is encoded by the HSF2 gene.[1][2]

Function

HSF2, as well as the related gene HSF1, encodes a protein that binds specifically to the heat-shock element and has homology to HSFs of other species. Heat shock transcription factors activate heat-shock response genes under conditions of heat or other stresses. Although the names HSF1 and HSF2 were chosen for historical reasons, these peptides should be referred to as heat-shock transcription factors.[2]

Interactions

HSF2 has been shown to interact with Nucleoporin 62[3] and HSF1.[4]

See also

References

  1. ↑ Schuetz TJ, Gallo GJ, Sheldon L, Tempst P, Kingston RE (Sep 1991). "Isolation of a cDNA for HSF2: evidence for two heat shock factor genes in humans". Proc Natl Acad Sci U S A 88 (16): 6911–5. doi:10.1073/pnas.88.16.6911. PMC 52203. PMID 1871106.
  2. 1 2 "Entrez Gene: HSF2 heat shock transcription factor 2".
  3. ↑ Yoshima T, Yura T, Yanagi H (Nov 1997). "The trimerization domain of human heat shock factor 2 is able to interact with nucleoporin p62". Biochem. Biophys. Res. Commun. 240 (1): 228–33. doi:10.1006/bbrc.1997.7662. PMID 9367915.
  4. ↑ He H, Soncin F, Grammatikakis N, Li Y, Siganou A, Gong J, Brown SA, Kingston RE, Calderwood SK (Sep 2003). "Elevated expression of heat shock factor (HSF) 2A stimulates HSF1-induced transcription during stress". J. Biol. Chem. 278 (37): 35465–75. doi:10.1074/jbc.M304663200. PMID 12813038.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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