EGR3

Early growth response 3
Identifiers
Symbols	EGR3 ; EGR-3; PILOT
External IDs	OMIM: 602419 MGI: 1306780 HomoloGene: 37923 GeneCards: EGR3 Gene
Gene ontology Molecular function • DNA binding • transcription factor activity, sequence-specific DNA binding • metal ion binding Cellular component • nucleus • cytoplasm Biological process • positive regulation of endothelial cell proliferation • cell migration involved in sprouting angiogenesis • transcription, DNA-templated • regulation of transcription, DNA-templated • neuromuscular synaptic transmission • peripheral nervous system development • muscle organ development • circadian rhythm • positive regulation of T cell differentiation in thymus • endothelial cell chemotaxis • cellular response to vascular endothelial growth factor stimulus • negative regulation of apoptotic process • cellular response to fibroblast growth factor stimulus • regulation of gamma-delta T cell differentiation • cellular response to cAMP • cellular response to gonadotropin stimulus Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1960	13655
Ensembl	ENSG00000179388	ENSMUSG00000033730
UniProt	Q06889	P43300
RefSeq (mRNA)	NM_001199880	NM_001289925
RefSeq (protein)	NP_001186809	NP_001276854
Location (UCSC)	Chr 8: 22.69 – 22.69 Mb	Chr 14: 70.08 – 70.08 Mb
PubMed search

Early growth response protein 3 is a protein that in humans is encoded by the EGR3 gene.^[1][2][3]

The gene encodes a transcriptional regulator that belongs to the EGR family of C2H2-type zinc-finger proteins. It is an immediate-early growth response gene which is induced by mitogenic stimulation. The protein encoded by this gene participates in the transcriptional regulation of genes in controlling biological rhythm. It may also play a role in muscle development.^[3]

References

1. Patwardhan S, Gashler A, Siegel MG, Chang LC, Joseph LJ, Shows TB, Le Beau MM, Sukhatme VP (Aug 1991). "EGR3, a novel member of the Egr family of genes encoding immediate-early transcription factors". Oncogene 6 (6): 917–28. PMID 1906159.
2. Yang Y, Dong B, Mittelstadt PR, Xiao H, Ashwell JD (May 2002). "HIV Tat binds Egr proteins and enhances Egr-dependent transactivation of the Fas ligand promoter". J Biol Chem 277 (22): 19482–19487. doi:10.1074/jbc.M201687200. PMID 11909874.
3. "Entrez Gene: EGR3 early growth response 3".

Further reading

• Yamada K, Gerber DJ, Iwayama Y, et al. (2007). "Genetic analysis of the calcineurin pathway identifies members of the EGR gene family, specifically EGR3, as potential susceptibility candidates in schizophrenia". Proc. Natl. Acad. Sci. U.S.A. 104 (8): 2815–2820. doi:10.1073/pnas.0610765104. PMC 1815264. PMID 17360599.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Yoo YG, Lee MO (2004). "Hepatitis B virus X protein induces expression of Fas ligand gene through enhancing transcriptional activity of early growth response factor". J. Biol. Chem. 279 (35): 36242–36249. doi:10.1074/jbc.M401290200. PMID 15173177.
• Inoue A, Omoto Y, Yamaguchi Y, et al. (2005). "Transcription factor EGR3 is involved in the estrogen-signaling pathway in breast cancer cells". J. Mol. Endocrinol. 32 (3): 649–661. doi:10.1677/jme.0.0320649. PMID 15171706.
• Liu D, Jia H, Holmes DI, et al. (2004). "Vascular endothelial growth factor-regulated gene expression in endothelial cells: KDR-mediated induction of Egr3 and the related nuclear receptors Nur77, Nurr1, and Nor1". Arterioscler. Thromb. Vasc. Biol. 23 (11): 2002–2007. doi:10.1161/01.ATV.0000098644.03153.6F. PMID 14525795.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Tourtellotte WG, Milbrandt J (1998). "Sensory ataxia and muscle spindle agenesis in mice lacking the transcription factor Egr3". Nat. Genet. 20 (1): 87–91. doi:10.1038/1757. PMID 9731539.
• Morris ME, Viswanathan N, Kuhlman S, et al. (1998). "A screen for genes induced in the suprachiasmatic nucleus by light". Science 279 (5356): 1544–1547. doi:10.1126/science.279.5356.1544. PMID 9488654.
• Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–828. doi:10.1101/gr.6.9.807. PMID 8889549.
• Mages HW, Stamminger T, Rilke O, et al. (1993). "Expression of PILOT, a putative transcription factor, requires two signals and is cyclosporin A sensitive in T cells". Int. Immunol. 5 (1): 63–70. doi:10.1093/intimm/5.1.63. PMID 8443122.

External links

• EGR3 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.