FOXK2

Forkhead box K2
PDB rendering based on 1jxs.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1JXS​, 2C6Y​
Identifiers
Symbols	FOXK2 ; ILF; ILF-1; ILF1
External IDs	OMIM: 147685 MGI: 1916087 HomoloGene: 18748 GeneCards: FOXK2 Gene
Gene ontology Molecular function • magnesium ion binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • transcription factor activity, sequence-specific DNA binding • protein binding • sequence-specific DNA binding Cellular component • nucleus • nucleoplasm • intracellular membrane-bounded organelle Biological process • regulation of transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • anatomical structure morphogenesis • cell differentiation • positive regulation of transcription from RNA polymerase II promoter Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3607	68837
Ensembl	ENSG00000141568	ENSMUSG00000039275
UniProt	Q01167	Q3UCQ1
RefSeq (mRNA)	NM_004514	NM_001080932
RefSeq (protein)	NP_004505	NP_001074401
Location (UCSC)	Chr 17: 82.52 – 82.64 Mb	Chr 11: 121.26 – 121.31 Mb
PubMed search

Forkhead box protein K2 is a protein that in humans is encoded by the FOXK2 gene.^[1][2]

The protein encoded by this gene contains a fork head DNA binding domain. This protein can bind to the purine-rich motifs of the HIV long terminal repeat (LTR), and to the similar purine-rich motif in the interleukin 2 (IL2) promoter. It may be involved in the regulation of viral and cellular promoter elements.^[2]

References

1. Durand DB, Shaw JP, Bush MR, Replogle RE, Belagaje R, Crabtree GR (Jul 1988). "Characterization of antigen receptor response elements within the interleukin-2 enhancer". Mol Cell Biol 8 (4): 1715–24. PMC 363332. PMID 3260003.
2. "Entrez Gene: FOXK2 forkhead box K2".

Further reading

• Li C, Lusis AJ, Sparkes R; et al. (1992). "Characterization and chromosomal mapping of the gene encoding the cellular DNA binding protein ILF.". Genomics 13 (3): 665–71. doi:10.1016/0888-7543(92)90139-J. PMID 1339390.
• Li C, Lai CF, Sigman DS, Gaynor RB (1991). "Cloning of a cellular factor, interleukin binding factor, that binds to NFAT-like motifs in the human immunodeficiency virus long terminal repeat.". Proc. Natl. Acad. Sci. U.S.A. 88 (17): 7739–43. doi:10.1073/pnas.88.17.7739. PMC 52378. PMID 1909027.
• Nirula A, Moore DJ, Gaynor RB (1997). "Constitutive binding of the transcription factor interleukin-2 (IL-2) enhancer binding factor to the IL-2 promoter.". J. Biol. Chem. 272 (12): 7736–45. doi:10.1074/jbc.272.12.7736. PMID 9065434.
• Wiemann S, Weil B, Wellenreuther R; et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Liu PP, Chen YC, Li C; et al. (2003). "Solution structure of the DNA-binding domain of interleukin enhancer binding factor 1 (FOXK1a).". Proteins 49 (4): 543–53. doi:10.1002/prot.10227. PMID 12402362.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Tsai KL, Huang CY, Chang CH; et al. (2006). "Crystal structure of the human FOXK1a-DNA complex and its implications on the diverse binding specificity of winged helix/forkhead proteins.". J. Biol. Chem. 281 (25): 17400–9. doi:10.1074/jbc.M600478200. PMID 16624804.
• Zody MC, Garber M, Adams DJ; et al. (2006). "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.". Nature 440 (7087): 1045–9. doi:10.1038/nature04689. PMC 2610434. PMID 16625196.
• Beausoleil SA, Villén J, Gerber SA; et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.

External links

• FOXK2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.