CREB1

CAMP responsive element binding protein 1
PDB rendering based on 1dh3.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2LXT​
Identifiers
Symbols	CREB1 ; CREB
External IDs	OMIM: 123810 MGI: 88494 HomoloGene: 3223 ChEMBL: 5587 GeneCards: CREB1 Gene
Gene ontology Molecular function • RNA polymerase II core promoter proximal region sequence-specific DNA binding • RNA polymerase II distal enhancer sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • RNA polymerase II activating transcription factor binding • transcriptional activator activity, RNA polymerase II transcription factor binding • double-stranded DNA binding • transcription factor activity, sequence-specific DNA binding • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding • transcription cofactor activity • protein binding • enzyme binding • histone acetyltransferase binding • cAMP response element binding Cellular component • nucleus • nucleoplasm • nuclear euchromatin • mitochondrion • ATF4-CREB1 transcription factor complex Biological process • toll-like receptor signaling pathway • MyD88-dependent toll-like receptor signaling pathway • MyD88-independent toll-like receptor signaling pathway • transcription from RNA polymerase II promoter • protein phosphorylation • signal transduction • epidermal growth factor receptor signaling pathway • transforming growth factor beta receptor signaling pathway • activation of phospholipase C activity • Notch signaling pathway • synaptic transmission • axon guidance • lactation • memory • circadian rhythm • regulation of cell size • fibroblast growth factor receptor signaling pathway • response to organic substance • negative regulation of transcription by competitive promoter binding • viral process • pituitary gland development • positive regulation of transforming growth factor beta3 production • secretory granule organization • response to glucagon • toll-like receptor 2 signaling pathway • toll-like receptor 3 signaling pathway • toll-like receptor 4 signaling pathway • toll-like receptor 5 signaling pathway • toll-like receptor 9 signaling pathway • toll-like receptor 10 signaling pathway • TRIF-dependent toll-like receptor signaling pathway • Fc-epsilon receptor signaling pathway • toll-like receptor TLR1:TLR2 signaling pathway • toll-like receptor TLR6:TLR2 signaling pathway • positive regulation of multicellular organism growth • response to drug • regulation of circadian rhythm • regulation of apoptotic process • innate immune response • positive regulation of fat cell differentiation • positive regulation of osteoclast differentiation • positive regulation of transcription, DNA-templated • positive regulation of RNA polymerase II transcriptional preinitiation complex assembly • positive regulation of transcription from RNA polymerase II promoter • positive regulation of hormone secretion • positive regulation of lipid biosynthetic process • neurotrophin TRK receptor signaling pathway • phosphatidylinositol-mediated signaling • protein stabilization • stress-activated MAPK cascade • lung saccule development • Type I pneumocyte differentiation • cellular response to zinc ion Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1385	12912
Ensembl	ENSG00000118260	ENSMUSG00000025958
UniProt	P16220	Q01147
RefSeq (mRNA)	NM_004379	NM_001037726
RefSeq (protein)	NP_004370	NP_001032815
Location (UCSC)	Chr 2: 207.53 – 207.6 Mb	Chr 1: 64.53 – 64.6 Mb
PubMed search

CAMP responsive element binding protein 1, also known as CREB-1, is a protein that in humans is encoded by the CREB1 gene.^[1][2] This protein binds the cAMP response element, a DNA nucleotide sequence present in many viral and cellular promoters. The binding of CREB1 stimulates transcription.

This protein is a CREB transcription factor that is a member of the leucine zipper family of DNA-binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in two transcript variants encoding different isoforms.^[3]

See also

• CREB

Interactions

CREB1 has been shown to interact with:

• CEBPB ,^[4]
• CREB binding protein ,^{[5][6][7][8][9][10][11][12][13][14]}
• FHL2 ,^[15]
• FHL3 ,^[15]
• FHL5 .^[15]
• HTATIP ,^[16]
• P53 ,^[11] and
• RPS6KA5 .^[17][18]

References

1. Hoeffler JP, Meyer TE, Yun Y, Jameson JL, Habener JF (Dec 1988). "Cyclic AMP-responsive DNA-binding protein: structure based on a cloned placental cDNA". Science 242 (4884): 1430–3. doi:10.1126/science.2974179. PMID 2974179.
2. Taylor AK, Klisak I, Mohandas T, Sparkes RS, Li C, Gaynor R, Lusis AJ (Jul 1990). "Assignment of the human gene for CREB1 to chromosome 2q32.3-q34". Genomics 7 (3): 416–21. doi:10.1016/0888-7543(90)90176-U. PMID 2142119.
3. "Entrez Gene: CREB1 cAMP responsive element binding protein 1".
4. Chen Y, Zhuang S, Cassenaer S, Casteel DE, Gudi T, Boss GR, Pilz RB (Jun 2003). "Synergism between calcium and cyclic GMP in cyclic AMP response element-dependent transcriptional regulation requires cooperation between CREB and C/EBP-beta". Molecular and Cellular Biology 23 (12): 4066–82. doi:10.1128/MCB.23.12.4066-4082.2003. PMC 156132. PMID 12773552.
5. Shi Y, Venkataraman SL, Dodson GE, Mabb AM, LeBlanc S, Tibbetts RS (Apr 2004). "Direct regulation of CREB transcriptional activity by ATM in response to genotoxic stress". Proceedings of the National Academy of Sciences of the United States of America 101 (16): 5898–903. doi:10.1073/pnas.0307718101. PMC 395895. PMID 15073328.
6. Kim J, Jia L, Stallcup MR, Coetzee GA (Feb 2005). "The role of protein kinase A pathway and cAMP responsive element-binding protein in androgen receptor-mediated transcription at the prostate-specific antigen locus". Journal of Molecular Endocrinology 34 (1): 107–18. doi:10.1677/jme.1.01701. PMID 15691881.
7. Shimomura A, Ogawa Y, Kitani T, Fujisawa H, Hagiwara M (Jul 1996). "Calmodulin-dependent protein kinase II potentiates transcriptional activation through activating transcription factor 1 but not cAMP response element-binding protein". The Journal of Biological Chemistry 271 (30): 17957–60. doi:10.1074/jbc.271.30.17957. PMID 8663317.
8. Radhakrishnan I, Pérez-Alvarado GC, Parker D, Dyson HJ, Montminy MR, Wright PE (Dec 1997). "Solution structure of the KIX domain of CBP bound to the transactivation domain of CREB: a model for activator:coactivator interactions". Cell 91 (6): 741–52. doi:10.1016/S0092-8674(00)80463-8. PMID 9413984.
9. Sano Y, Tokitou F, Dai P, Maekawa T, Yamamoto T, Ishii S (Oct 1998). "CBP alleviates the intramolecular inhibition of ATF-2 function". The Journal of Biological Chemistry 273 (44): 29098–105. doi:10.1074/jbc.273.44.29098. PMID 9786917.
10. Zor T, Mayr BM, Dyson HJ, Montminy MR, Wright PE (Nov 2002). "Roles of phosphorylation and helix propensity in the binding of the KIX domain of CREB-binding protein by constitutive (c-Myb) and inducible (CREB) activators". The Journal of Biological Chemistry 277 (44): 42241–8. doi:10.1074/jbc.M207361200. PMID 12196545.
11. Giebler HA, Lemasson I, Nyborg JK (Jul 2000). "p53 recruitment of CREB binding protein mediated through phosphorylated CREB: a novel pathway of tumor suppressor regulation". Molecular and Cellular Biology 20 (13): 4849–58. doi:10.1128/MCB.20.13.4849-4858.2000. PMC 85936. PMID 10848610.
12. Zhang Q, Vo N, Goodman RH (Jul 2000). "Histone binding protein RbAp48 interacts with a complex of CREB binding protein and phosphorylated CREB". Molecular and Cellular Biology 20 (14): 4970–8. doi:10.1128/MCB.20.14.4970-4978.2000. PMC 85947. PMID 10866654.
13. Ernst P, Wang J, Huang M, Goodman RH, Korsmeyer SJ (Apr 2001). "MLL and CREB bind cooperatively to the nuclear coactivator CREB-binding protein". Molecular and Cellular Biology 21 (7): 2249–58. doi:10.1128/MCB.21.7.2249-2258.2001. PMC 86859. PMID 11259575.
14. Ledo F, Kremer L, Mellström B, Naranjo JR (Sep 2002). "Ca2+-dependent block of CREB-CBP transcription by repressor DREAM". The EMBO Journal 21 (17): 4583–92. doi:10.1093/emboj/cdf440. PMC 126180. PMID 12198160.
15. Fimia GM, De Cesare D, Sassone-Corsi P (Nov 2000). "A family of LIM-only transcriptional coactivators: tissue-specific expression and selective activation of CREB and CREM". Molecular and Cellular Biology 20 (22): 8613–22. doi:10.1128/MCB.20.22.8613-8622.2000. PMC 102166. PMID 11046156.
16. Gavaravarapu S, Kamine J (Mar 2000). "Tip60 inhibits activation of CREB protein by protein kinase A". Biochemical and Biophysical Research Communications 269 (3): 758–66. doi:10.1006/bbrc.2000.2358. PMID 10720489.
17. Deak M, Clifton AD, Lucocq LM, Alessi DR (Aug 1998). "Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB". The EMBO Journal 17 (15): 4426–41. doi:10.1093/emboj/17.15.4426. PMC 1170775. PMID 9687510.
18. Wang X, Li W, Williams M, Terada N, Alessi DR, Proud CG (Aug 2001). "Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase". The EMBO Journal 20 (16): 4370–9. doi:10.1093/emboj/20.16.4370. PMC 125559. PMID 11500364.

Further reading

• Don J, Stelzer G (Feb 2002). "The expanding family of CREB/CREM transcription factors that are involved with spermatogenesis". Molecular and Cellular Endocrinology 187 (1-2): 115–24. doi:10.1016/S0303-7207(01)00696-7. PMID 11988318.
• Pandey SC (Oct 2004). "The gene transcription factor cyclic AMP-responsive element binding protein: role in positive and negative affective states of alcohol addiction". Pharmacology & Therapeutics 104 (1): 47–58. doi:10.1016/j.pharmthera.2004.08.002. PMID 15500908.
• Wu H, Zhou Y, Xiong ZQ (Jul 2007). "Transducer of regulated CREB and late phase long-term synaptic potentiation". The FEBS Journal 274 (13): 3218–23. doi:10.1111/j.1742-4658.2007.05891.x. PMID 17565597.
• Kitagawa K (Jul 2007). "CREB and cAMP response element-mediated gene expression in the ischemic brain". The FEBS Journal 274 (13): 3210–7. doi:10.1111/j.1742-4658.2007.05890.x. PMID 17565598.
• Takemori H, Kajimura J, Okamoto M (Jul 2007). "TORC-SIK cascade regulates CREB activity through the basic leucine zipper domain". The FEBS Journal 274 (13): 3202–9. doi:10.1111/j.1742-4658.2007.05889.x. PMID 17565599.
• Siu YT, Jin DY (Jul 2007). "CREB--a real culprit in oncogenesis". The FEBS Journal 274 (13): 3224–32. doi:10.1111/j.1742-4658.2007.05884.x. PMID 17565603.

External links

• CREB1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.