CDX1

Caudal type homeobox 1
Identifiers
Symbols	CDX1 ; MGC116915
External IDs	OMIM: 600746 MGI: 88360 HomoloGene: 1366 GeneCards: CDX1 Gene
Gene ontology Molecular function • RNA polymerase II distal enhancer sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding • protein binding Cellular component • nucleus Biological process • transcription from RNA polymerase II promoter • organ morphogenesis • anterior/posterior pattern specification • positive regulation of transcription from RNA polymerase II promoter • bone morphogenesis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1044	12590
Ensembl	ENSG00000113722	ENSMUSG00000024619
UniProt	P47902	P18111
RefSeq (mRNA)	NM_001804	NM_009880
RefSeq (protein)	NP_001795	NP_034010
Location (UCSC)	Chr 5: 150.17 – 150.18 Mb	Chr 18: 61.02 – 61.04 Mb
PubMed search

Homeobox protein CDX-1 is a protein that in humans is encoded by the CDX1 gene.^[1][2]

Function

This gene is a member of the caudal-related homeobox transcription factor family. The encoded DNA-binding protein regulates intestine-specific gene expression and enterocyte differentiation. It has been shown to induce expression of the intestinal alkaline phosphatase gene, and inhibit beta-catenin/T-cell factor transcriptional activity.^[2]

References

1. Bonner CA, Loftus SK, Wasmuth JJ (Jul 1995). "Isolation, characterization, and precise physical localization of human CDX1, a caudal-type homeobox gene". Genomics 28 (2): 206–11. doi:10.1006/geno.1995.1132. PMID 8530027.
2. "Entrez Gene: CDX1 caudal type homeobox transcription factor 1".

Further reading

• "Positional cloning of a gene involved in the pathogenesis of Treacher Collins syndrome. The Treacher Collins Syndrome Collaborative Group". Nature Genetics 12 (2): 130–6. Feb 1996. doi:10.1038/ng0296-130. PMID 8563749.
• Mallo GV, Rechreche H, Frigerio JM, Rocha D, Zweibaum A, Lacasa M, Jordan BR, Dusetti NJ, Dagorn JC, Iovanna JL (Feb 1997). "Molecular cloning, sequencing and expression of the mRNA encoding human Cdx1 and Cdx2 homeobox. Down-regulation of Cdx1 and Cdx2 mRNA expression during colorectal carcinogenesis". International Journal of Cancer. Journal International Du Cancer 74 (1): 35–44. doi:10.1002/(SICI)1097-0215(19970220)74:1<35::AID-IJC7>3.0.CO;2-1. PMID 9036867.
• Mizoshita T, Inada K, Tsukamoto T, Kodera Y, Yamamura Y, Hirai T, Kato T, Joh T, Itoh M, Tatematsu M (2002). "Expression of Cdx1 and Cdx2 mRNAs and relevance of this expression to differentiation in human gastrointestinal mucosa--with special emphasis on participation in intestinal metaplasia of the human stomach". Gastric Cancer 4 (4): 185–91. doi:10.1007/PL00011741. PMID 11846061.
• Suh ER, Ha CS, Rankin EB, Toyota M, Traber PG (Sep 2002). "DNA methylation down-regulates CDX1 gene expression in colorectal cancer cell lines". The Journal of Biological Chemistry 277 (39): 35795–800. doi:10.1074/jbc.M205567200. PMID 12124393.
• Domon-Dell C, Schneider A, Moucadel V, Guerin E, Guenot D, Aguillon S, Duluc I, Martin E, Iovanna J, Launay JF, Duclos B, Chenard MP, Meyer C, Oudet P, Kedinger M, Gaub MP, Freund JN (Sep 2003). "Cdx1 homeobox gene during human colon cancer progression". Oncogene 22 (39): 7913–21. doi:10.1038/sj.onc.1206756. PMID 12970739.
• Wong NA, Britton MP, Choi GS, Stanton TK, Bicknell DC, Wilding JL, Bodmer WF (Jan 2004). "Loss of CDX1 expression in colorectal carcinoma: promoter methylation, mutation, and loss of heterozygosity analyses of 37 cell lines". Proceedings of the National Academy of Sciences of the United States of America 101 (2): 574–9. doi:10.1073/pnas.0307190101. PMC 327189. PMID 14704280.
• Rankin EB, Xu W, Silberg DG, Suh E (May 2004). "Putative intestine-specific enhancers located in 5' sequence of the CDX1 gene regulate CDX1 expression in the intestine". American Journal of Physiology. Gastrointestinal and Liver Physiology 286 (5): G872–80. doi:10.1152/ajpgi.00326.2003. PMID 14715525.
• Béland M, Pilon N, Houle M, Oh K, Sylvestre JR, Prinos P, Lohnes D (Jun 2004). "Cdx1 autoregulation is governed by a novel Cdx1-LEF1 transcription complex". Molecular and Cellular Biology 24 (11): 5028–38. doi:10.1128/MCB.24.11.5028-5038.2004. PMC 416402. PMID 15143193.
• Guo RJ, Huang E, Ezaki T, Patel N, Sinclair K, Wu J, Klein P, Suh ER, Lynch JP (Aug 2004). "Cdx1 inhibits human colon cancer cell proliferation by reducing beta-catenin/T-cell factor transcriptional activity". The Journal of Biological Chemistry 279 (35): 36865–75. doi:10.1074/jbc.M405213200. PMID 15215241.
• Alkhoury F, Malo MS, Mozumder M, Mostafa G, Hodin RA (Aug 2005). "Differential regulation of intestinal alkaline phosphatase gene expression by Cdx1 and Cdx2". American Journal of Physiology. Gastrointestinal and Liver Physiology 289 (2): G285–90. doi:10.1152/ajpgi.00037.2005. PMID 15774940.
• Wong NA, Wilding J, Bartlett S, Liu Y, Warren BF, Piris J, Maynard N, Marshall R, Bodmer WF (May 2005). "CDX1 is an important molecular mediator of Barrett's metaplasia". Proceedings of the National Academy of Sciences of the United States of America 102 (21): 7565–70. doi:10.1073/pnas.0502031102. PMC 1140438. PMID 15894614.

External links

• CDX1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.