PBX2

Pre-B-cell leukemia homeobox 2
Cartoon diagram of a HOXB1–PBX1 heterodimer (violet) binding a DNA fragment (blue). Rendering based on PDB 1b72.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1b72​, 1b8i​, 1du6​, 1lfu​, 1puf​
Identifiers
Symbols	PBX2 ; G17; HOX12; PBX2MHC
External IDs	OMIM: 176311 MGI: 1341793 HomoloGene: 48115 GeneCards: PBX2 Gene
Gene ontology Molecular function • chromatin binding • transcription factor activity, sequence-specific DNA binding • protein binding • transcription factor binding • sequence-specific DNA binding Cellular component • nucleus • transcription factor complex Biological process • transcription, DNA-templated • proximal/distal pattern formation • embryonic limb morphogenesis • positive regulation of transcription from RNA polymerase II promoter Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5089	18515
Ensembl	ENSG00000204304	ENSMUSG00000034673
UniProt	P40425	O35984
RefSeq (mRNA)	NM_002586	NM_017463
RefSeq (protein)	NP_002577	NP_059491
Location (UCSC)	Chr 6: 32.18 – 32.19 Mb	Chr 17: 34.59 – 34.6 Mb
PubMed search

Pre-B-cell leukemia transcription factor 2 is a protein that in humans is encoded by the PBX2 gene.^[1][2]

Function

This gene encodes a ubiquitously expressed member of the TALE/PBX homeobox family. It was identified by its similarity to a homeobox gene which is involved in t(1;19) translocation in acute pre-B-cell leukemias. This protein is a transcriptional activator which binds to the TLX1 promoter. The gene is located within the major histocompatibility complex (MHC) on chromosome 6.^[2]

Interactions

PBX2 has been shown to interact with HOXA9.^[3]

References

1. Sugaya K, Fukagawa T, Matsumoto K, Mita K, Takahashi E, Ando A, Inoko H, Ikemura T (Sep 1994). "Three genes in the human MHC class III region near the junction with the class II: gene for receptor of advanced glycosylation end products, PBX2 homeobox gene and a notch homolog, human counterpart of mouse mammary tumor gene int-3". Genomics 23 (2): 408–19. doi:10.1006/geno.1994.1517. PMID 7835890.
2. "Entrez Gene: PBX2 pre-B-cell leukemia homeobox 2".
3. Shen WF, Rozenfeld S, Kwong A, Köm ves LG, Lawrence HJ, Largman C (Apr 1999). "HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells". Molecular and Cellular Biology 19 (4): 3051–61. PMC 84099. PMID 10082572.

Further reading

• Monica K, Galili N, Nourse J, Saltman D, Cleary ML (Dec 1991). "PBX2 and PBX3, new homeobox genes with extensive homology to the human proto-oncogene PBX1". Molecular and Cellular Biology 11 (12): 6149–57. PMC 361792. PMID 1682799.
• Aguado B, Campbell RD (Feb 1995). "The novel gene G17, located in the human major histocompatibility complex, encodes PBX2, a homeodomain-containing protein". Genomics 25 (3): 650–9. doi:10.1016/0888-7543(95)80007-9. PMID 7759099.
• Lu Q, Wright DD, Kamps MP (Jun 1994). "Fusion with E2A converts the Pbx1 homeodomain protein into a constitutive transcriptional activator in human leukemias carrying the t(1;19) translocation". Molecular and Cellular Biology 14 (6): 3938–48. PMC 358760. PMID 7910944.
• Katsanis N, Fitzgibbon J, Fisher EM (Jul 1996). "Paralogy mapping: identification of a region in the human MHC triplicated onto human chromosomes 1 and 9 allows the prediction and isolation of novel PBX and NOTCH loci". Genomics 35 (1): 101–8. doi:10.1006/geno.1996.0328. PMID 8661110.
• Berthelsen J, Zappavigna V, Mavilio F, Blasi F (Mar 1998). "Prep1, a novel functional partner of Pbx proteins". The EMBO Journal 17 (5): 1423–33. doi:10.1093/emboj/17.5.1423. PMC 1170490. PMID 9482739.
• Shen WF, Rozenfeld S, Kwong A, Köm ves LG, Lawrence HJ, Largman C (Apr 1999). "HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells". Molecular and Cellular Biology 19 (4): 3051–61. PMC 84099. PMID 10082572.
• Fujino T, Yamazaki Y, Largaespada DA, Jenkins NA, Copeland NG, Hirokawa K, Nakamura T (Jul 2001). "Inhibition of myeloid differentiation by Hoxa9, Hoxb8, and Meis homeobox genes". Experimental Hematology 29 (7): 856–63. doi:10.1016/S0301-472X(01)00655-5. PMID 11438208.
• Brake RL, Kees UR, Watt PM (May 2002). "A complex containing PBX2 contributes to activation of the proto-oncogene HOX11". Biochemical and Biophysical Research Communications 294 (1): 23–34. doi:10.1016/S0006-291X(02)00426-6. PMID 12054735.
• Okada Y, Nagai R, Sato T, Matsuura E, Minami T, Morita I, Doi T (Jun 2003). "Homeodomain proteins MEIS1 and PBXs regulate the lineage-specific transcription of the platelet factor 4 gene". Blood 101 (12): 4748–56. doi:10.1182/blood-2002-02-0380. PMID 12609849.
• Longobardi E, Blasi F (Oct 2003). "Overexpression of PREP-1 in F9 teratocarcinoma cells leads to a functionally relevant increase of PBX-2 by preventing its degradation". The Journal of Biological Chemistry 278 (40): 39235–41. doi:10.1074/jbc.M304704200. PMID 12871956.
• Xie T, Rowen L, Aguado B, Ahearn ME, Madan A, Qin S, Campbell RD, Hood L (Dec 2003). "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse". Genome Research 13 (12): 2621–36. doi:10.1101/gr.1736803. PMC 403804. PMID 14656967.
• Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM (Jan 2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.

External links

• PBX2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.