HOXB5

Homeobox B5
PDB rendering based on 1hom.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1hom​, 1san​
Identifiers
Symbols	HOXB5 ; HHO.C10; HOX2; HOX2A; HU-1; Hox2.1
External IDs	OMIM: 142960 MGI: 96186 HomoloGene: 37585 GeneCards: HOXB5 Gene
Gene ontology Molecular function • RNA polymerase II distal enhancer sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding • protein binding Cellular component • nucleus Biological process • transcription from RNA polymerase II promoter • anatomical structure morphogenesis • anterior/posterior pattern specification • endothelial cell differentiation • positive regulation of transcription from RNA polymerase II promoter • embryonic skeletal system morphogenesis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3215	15413
Ensembl	ENSG00000120075	ENSMUSG00000038700
UniProt	P09067	P09079
RefSeq (mRNA)	NM_002147	NM_008268
RefSeq (protein)	NP_002138	NP_032294
Location (UCSC)	Chr 17: 48.59 – 48.59 Mb	Chr 11: 96.3 – 96.31 Mb
PubMed search

Homeobox protein Hox-B5 is a protein that in humans is encoded by the HOXB5 gene.^[1][2][3]

Function

This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in lung and gut development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML) and the occurrence of bronchopulmonary sequestration (BPS) and congenital cystic adenomatoid malformation (CCAM) tissue.^[3]

See also

• Homeobox

References

1. McAlpine PJ, Shows TB (Jul 1990). "Nomenclature for human homeobox genes". Genomics 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
2. Scott MP (Nov 1992). "Vertebrate homeobox gene nomenclature". Cell 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459.
3. "Entrez Gene: HOXB5 homeobox B5".

Further reading

• Galang CK, Hauser CA (May 1992). "Cooperative DNA binding of the highly conserved human Hox 2.1 homeodomain gene product". The New Biologist 4 (5): 558–68. PMID 1355360.
• Peverali FA, D'Esposito M, Acampora D, Bunone G, Negri M, Faiella A, Stornaiuolo A, Pannese M, Migliaccio E, Simeone A (Oct 1990). "Expression of HOX homeogenes in human neuroblastoma cell culture lines". Differentiation; Research in Biological Diversity 45 (1): 61–9. doi:10.1111/j.1432-0436.1990.tb00458.x. PMID 1981366.
• Giampaolo A, Acampora D, Zappavigna V, Pannese M, D'Esposito M, Carè A, Faiella A, Stornaiuolo A, Russo G, Simeone A (Jun 1989). "Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system". Differentiation; Research in Biological Diversity 40 (3): 191–7. doi:10.1111/j.1432-0436.1989.tb00598.x. PMID 2570724.
• Acampora D, D'Esposito M, Faiella A, Pannese M, Migliaccio E, Morelli F, Stornaiuolo A, Nigro V, Simeone A, Boncinelli E (Dec 1989). "The human HOX gene family". Nucleic Acids Research 17 (24): 10385–402. doi:10.1093/nar/17.24.10385. PMC 335308. PMID 2574852.
• Boncinelli E, Acampora D, Pannese M, D'Esposito M, Somma R, Gaudino G, Stornaiuolo A, Cafiero M, Faiella A, Simeone A (1990). "Organization of human class I homeobox genes". Genome / National Research Council Canada = Génome / Conseil National De Recherches Canada 31 (2): 745–56. doi:10.1139/g89-133. PMID 2576652.
• Rabin M, Ferguson-Smith A, Hart CP, Ruddle FH (Dec 1986). "Cognate homeo-box loci mapped on homologous human and mouse chromosomes". Proceedings of the National Academy of Sciences of the United States of America 83 (23): 9104–8. doi:10.1073/pnas.83.23.9104. PMC 387083. PMID 2878432.
• Hart CP, Awgulewitsch A, Fainsod A, McGinnis W, Ruddle FH (Nov 1985). "Homeo box gene complex on mouse chromosome 11: molecular cloning, expression in embryogenesis, and homology to a human homeo box locus". Cell 43 (1): 9–18. doi:10.1016/0092-8674(85)90007-8. PMID 3000607.
• Xu WM, Gorman PA, Rider SH, Hedge PJ, Moore G, Prichard C, Sheer D, Solomon E (Nov 1988). "Construction of a genetic map of human chromosome 17 by use of chromosome-mediated gene transfer". Proceedings of the National Academy of Sciences of the United States of America 85 (22): 8563–7. doi:10.1073/pnas.85.22.8563. PMC 282499. PMID 3186746.
• Simeone A, Mavilio F, Bottero L, Giampaolo A, Russo G, Faiella A, Boncinelli E, Peschle C (1986). "A human homoeo box gene specifically expressed in spinal cord during embryonic development". Nature 320 (6064): 763–5. doi:10.1038/320763a0. PMID 3453105.
• Hauser CA, Joyner AL, Klein RD, Learned TK, Martin GR, Tjian R (Nov 1985). "Expression of homologous homeo-box-containing genes in differentiated human teratocarcinoma cells and mouse embryos". Cell 43 (1): 19–28. doi:10.1016/0092-8674(85)90008-X. PMID 4075393.
• Levine M, Rubin GM, Tjian R (Oct 1984). "Human DNA sequences homologous to a protein coding region conserved between homeotic genes of Drosophila". Cell 38 (3): 667–73. doi:10.1016/0092-8674(84)90261-7. PMID 6091895.
• Galang CK, Hauser CA (Aug 1993). "Cooperative DNA binding of the human HoxB5 (Hox-2.1) protein is under redox regulation in vitro". Molecular and Cellular Biology 13 (8): 4609–17. doi:10.1128/mcb.13.8.4609. PMC 360087. PMID 8101633.
• Apiou F, Flagiello D, Cillo C, Malfoy B, Poupon MF, Dutrillaux B (1996). "Fine mapping of human HOX gene clusters". Cytogenetics and Cell Genetics 73 (1-2): 114–5. doi:10.1159/000134320. PMID 8646877.
• Kuliev A, Kukharenko V, Morozov G, Freidine M, Rechitsky S, Verlinsky O, Ivakhnenko V, Gindilis V, Strom C, Verlinsky Y (Feb 1996). "Expression of homebox-containing genes in human preimplantation development and in embryos with chromosomal aneuploidies". Journal of Assisted Reproduction and Genetics 13 (2): 177–81. doi:10.1007/BF02072541. PMID 8688592.
• Sakach M, Safaei R (Aug 1996). "Localization of the HoxB5 protein in the developing CNS of late gestational mouse embryos". International Journal of Developmental Neuroscience 14 (5): 567–73. doi:10.1016/0736-5748(96)00052-4. PMID 8930688.
• Archavachotikul K, Ciccone TJ, Chinoy MR, Nielsen HC, Volpe MV (Mar 2002). "Thyroid hormone affects embryonic mouse lung branching morphogenesis and cellular differentiation". American Journal of Physiology. Lung Cellular and Molecular Physiology 282 (3): L359–69. doi:10.1203/00006450-199904020-00286. PMID 11839528.
• Kosaki K, Kosaki R, Suzuki T, Yoshihashi H, Takahashi T, Sasaki K, Tomita M, McGinnis W, Matsuo N (Feb 2002). "Complete mutation analysis panel of the 39 human HOX genes". Teratology 65 (2): 50–62. doi:10.1002/tera.10009. PMID 11857506.

External links

• HOXB5 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.