BLZF1

Basic leucine zipper nuclear factor 1
Identifiers
Symbols	BLZF1 ; GOLGIN-45; JEM-1; JEM-1s; JEM1
External IDs	OMIM: 608692 MGI: 1201607 HomoloGene: 31187 GeneCards: BLZF1 Gene
Gene ontology Molecular function • DNA binding • transcription factor activity, sequence-specific DNA binding • protein binding • enzyme binding • ubiquitin protein ligase binding Cellular component • Golgi membrane • nucleus • nucleoplasm • cytoplasm • Golgi lumen Biological process • mitotic cell cycle • regulation of cell growth • regulation of transcription from RNA polymerase II promoter • Golgi organization • cell proliferation • Golgi to plasma membrane protein transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8548	66352
Ensembl	ENSG00000117475	ENSMUSG00000026577
UniProt	Q9H2G9	Q8R2X8
RefSeq (mRNA)	NM_003666	NM_001160208
RefSeq (protein)	NP_003657	NP_001153680
Location (UCSC)	Chr 1: 169.37 – 169.4 Mb	Chr 1: 164.29 – 164.31 Mb
PubMed search

Golgin-45 is a protein that in humans is encoded by the BLZF1 gene.^[1][2]

Interactions

BLZF1 has been shown to interact with GORASP2.^[3]

References

1. Duprez E, Tong JH, Dérré J, Chen SJ, Berger R, Chen Z, Lanotte M (May 1997). "JEM-1, a novel gene encoding a leucine-zipper nuclear factor upregulated during retinoid-induced maturation of NB4 promyelocytic leukaemia". Oncogene 14 (13): 1563–70. doi:10.1038/sj.onc.1200995. PMID 9129147.
2. "Entrez Gene: BLZF1 basic leucine zipper nuclear factor 1 (JEM-1)".
3. Barr FA, Preisinger C, Kopajtich R, Körner R (Dec 2001). "Golgi matrix proteins interact with p24 cargo receptors and aid their efficient retention in the Golgi apparatus". J. Cell Biol. 155 (6): 885–91. doi:10.1083/jcb.200108102. PMC 2150891. PMID 11739402.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Ting NS, Kao PN, Chan DW, Lintott LG, Lees-Miller SP (1998). "DNA-dependent protein kinase interacts with antigen receptor response element binding proteins NF90 and NF45". J. Biol. Chem. 273 (4): 2136–45. doi:10.1074/jbc.273.4.2136. PMID 9442054.
• Tong JH, Fant X, Duprez E, Benoit G, Uphoff CC, Drexler HG, Pla JC, Lofvenberg E, Lanotte M (1998). "Expression patterns of the JEM-1 gene in normal and tumor cells: ubiquity contrasting with a faint, but retinoid-induced, mRNA expression in promyelocytic NB4 cells". Leukemia 12 (11): 1733–40. doi:10.1038/sj.leu.2401173. PMID 9823948.
• Tong JH, Duprez E, Lanotte M (1999). "JEM-1, a novel nuclear co-factor: localisation and functional interaction with AP-1". Leukemia 13 (12): 1982–92. doi:10.1038/sj/leu/2401560. PMID 10602419.
• Tong JH, Fant X, Benoit G, Chen SJ, Chen Z, Lanotte M (2000). "Genomic organization of the JEM-1 (BLZF1) gene on human chromosome 1q24: molecular cloning and analysis of its promoter region". Genomics 69 (3): 380–90. doi:10.1006/geno.2000.6347. PMID 11056056.
• Short B, Preisinger C, Körner R, Kopajtich R, Byron O, Barr FA (2001). "A GRASP55-rab2 effector complex linking Golgi structure to membrane traffic". J. Cell Biol. 155 (6): 877–83. doi:10.1083/jcb.200108079. PMC 2150909. PMID 11739401.
• Reichman TW, Muñiz LC, Mathews MB (2002). "The RNA binding protein nuclear factor 90 functions as both a positive and negative regulator of gene expression in mammalian cells". Mol. Cell. Biol. 22 (1): 343–56. doi:10.1128/MCB.22.1.343-356.2002. PMC 134226. PMID 11739746.

External links

• BLZF1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.