Retinoblastoma-like protein 2

Retinoblastoma-like 2
Identifiers
Symbols	RBL2 ; P130; Rb2
External IDs	OMIM: 180203 MGI: 105085 HomoloGene: 4098 GeneCards: RBL2 Gene
Gene ontology Molecular function • DNA binding • protein binding Cellular component • nucleus • nucleoplasm • transcription factor complex • nucleolus • cytoplasm • extracellular exosome Biological process • mitotic cell cycle • transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter • chromatin modification • regulation of lipid kinase activity • regulation of cell cycle Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5934	19651
Ensembl	ENSG00000103479	ENSMUSG00000031666
UniProt	Q08999	Q64700
RefSeq (mRNA)	NM_005611	NM_001282000
RefSeq (protein)	NP_005602	NP_001268929
Location (UCSC)	Chr 16: 53.43 – 53.49 Mb	Chr 8: 91.07 – 91.12 Mb
PubMed search

Retinoblastoma-like protein 2 is a protein that in humans is encoded by the RBL2 gene.^[1][2]

Interactions

Retinoblastoma-like protein 2 has been shown to interact with:

• BRCA1,^[3]
• BRF1^[4]
• C-Raf,^[5]
• Cyclin E1,^[6][7]
• Cyclin-dependent kinase 2,^[6][8]
• HDAC1,^[9][10]
• Prohibitin,^[11] and
• RBBP8.^[12][13]

See also

• Pocket protein family

References

1. Mayol X, Graña X, Baldi A, Sang N, Hu Q, Giordano A (Sep 1993). "Cloning of a new member of the retinoblastoma gene family (pRb2) which binds to the E1A transforming domain". Oncogene 8 (9): 2561–6. PMID 8361765.
2. Baldi A, Boccia V, Claudio PP, De Luca A, Giordano A (May 1996). "Genomic structure of the human retinoblastoma-related Rb2/p130 gene". Proceedings of the National Academy of Sciences of the United States of America 93 (10): 4629–32. doi:10.1073/pnas.93.10.4629. PMC 39329. PMID 8643454.
3. Fan S, Yuan R, Ma YX, Xiong J, Meng Q, Erdos M, Zhao JN, Goldberg ID, Pestell RG, Rosen EM (Aug 2001). "Disruption of BRCA1 LXCXE motif alters BRCA1 functional activity and regulation of RB family but not RB protein binding". Oncogene 20 (35): 4827–41. doi:10.1038/sj.onc.1204666. PMID 11521194.
4. Sutcliffe JE, Cairns CA, McLees A, Allison SJ, Tosh K, White RJ (Jun 1999). "RNA polymerase III transcription factor IIIB is a target for repression by pocket proteins p107 and p130". Molecular and Cellular Biology 19 (6): 4255–61. doi:10.1128/mcb.19.6.4255. PMC 104385. PMID 10330166.
5. Wang S, Ghosh RN, Chellappan SP (Dec 1998). "Raf-1 physically interacts with Rb and regulates its function: a link between mitogenic signaling and cell cycle regulation". Molecular and Cellular Biology 18 (12): 7487–98. doi:10.1128/mcb.18.12.7487. PMC 109329. PMID 9819434.
6. Shanahan F, Seghezzi W, Parry D, Mahony D, Lees E (Feb 1999). "Cyclin E associates with BAF155 and BRG1, components of the mammalian SWI-SNF complex, and alters the ability of BRG1 to induce growth arrest". Molecular and Cellular Biology 19 (2): 1460–9. doi:10.1128/mcb.19.2.1460. PMC 116074. PMID 9891079.
7. Li Y, Graham C, Lacy S, Duncan AM, Whyte P (Dec 1993). "The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E". Genes & Development 7 (12A): 2366–77. doi:10.1101/gad.7.12a.2366. PMID 8253383.
8. Lacy S, Whyte P (May 1997). "Identification of a p130 domain mediating interactions with cyclin A/cdk 2 and cyclin E/cdk 2 complexes". Oncogene 14 (20): 2395–406. doi:10.1038/sj.onc.1201085. PMID 9188854.
9. Ferreira R, Magnaghi-Jaulin L, Robin P, Harel-Bellan A, Trouche D (Sep 1998). "The three members of the pocket proteins family share the ability to repress E2F activity through recruitment of a histone deacetylase". Proceedings of the National Academy of Sciences of the United States of America 95 (18): 10493–8. doi:10.1073/pnas.95.18.10493. PMC 27922. PMID 9724731.
10. Bouzahzah B, Fu M, Iavarone A, Factor VM, Thorgeirsson SS, Pestell RG (Aug 2000). "Transforming growth factor-beta1 recruits histone deacetylase 1 to a p130 repressor complex in transgenic mice in vivo". Cancer Research 60 (16): 4531–7. PMID 10969803.
11. Wang S, Nath N, Adlam M, Chellappan S (Jun 1999). "Prohibitin, a potential tumor suppressor, interacts with RB and regulates E2F function". Oncogene 18 (23): 3501–10. doi:10.1038/sj.onc.1202684. PMID 10376528.
12. Meloni AR, Smith EJ, Nevins JR (Aug 1999). "A mechanism for Rb/p130-mediated transcription repression involving recruitment of the CtBP corepressor". Proceedings of the National Academy of Sciences of the United States of America 96 (17): 9574–9. doi:10.1073/pnas.96.17.9574. PMC 22250. PMID 10449734.
13. Fusco C, Reymond A, Zervos AS (Aug 1998). "Molecular cloning and characterization of a novel retinoblastoma-binding protein". Genomics 51 (3): 351–8. doi:10.1006/geno.1998.5368. PMID 9721205.

Further reading

• Soprano KJ, Purev E, Vuocolo S, Soprano DR (Aug 2006). "Rb2/p130 and protein phosphatase 2A: key mediators of ovarian carcinoma cell growth suppression by all-trans retinoic acid". Oncogene 25 (38): 5315–25. doi:10.1038/sj.onc.1209679. PMID 16936753.
• De Falco G, Giordano A (Aug 2006). "pRb2/p130: a new candidate for retinoblastoma tumor formation". Oncogene 25 (38): 5333–40. doi:10.1038/sj.onc.1209614. PMID 16936755.
• Hijmans EM, Voorhoeve PM, Beijersbergen RL, van 't Veer LJ, Bernards R (Jun 1995). "E2F-5, a new E2F family member that interacts with p130 in vivo". Molecular and Cellular Biology 15 (6): 3082–9. doi:10.1128/mcb.15.6.3082. PMC 230539. PMID 7760804.
• Sardet C, Vidal M, Cobrinik D, Geng Y, Onufryk C, Chen A, Weinberg RA (Mar 1995). "E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle". Proceedings of the National Academy of Sciences of the United States of America 92 (6): 2403–7. doi:10.1073/pnas.92.6.2403. PMC 42492. PMID 7892279.
• Yeung RS, Bell DW, Testa JR, Mayol X, Baldi A, Graña X, Klinga-Levan K, Knudson AG, Giordano A (Dec 1993). "The retinoblastoma-related gene, RB2, maps to human chromosome 16q12 and rat chromosome 19". Oncogene 8 (12): 3465–8. PMID 8247552.
• Li Y, Graham C, Lacy S, Duncan AM, Whyte P (Dec 1993). "The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E". Genes & Development 7 (12A): 2366–77. doi:10.1101/gad.7.12a.2366. PMID 8253383.
• Hannon GJ, Demetrick D, Beach D (Dec 1993). "Isolation of the Rb-related p130 through its interaction with CDK2 and cyclins". Genes & Development 7 (12A): 2378–91. doi:10.1101/gad.7.12a.2378. PMID 8253384.
• Lavender P, Vandel L, Bannister AJ, Kouzarides T (Jun 1997). "The HMG-box transcription factor HBP1 is targeted by the pocket proteins and E1A". Oncogene 14 (22): 2721–8. doi:10.1038/sj.onc.1201243. PMID 9178770.
• Lacy S, Whyte P (May 1997). "Identification of a p130 domain mediating interactions with cyclin A/cdk 2 and cyclin E/cdk 2 complexes". Oncogene 14 (20): 2395–406. doi:10.1038/sj.onc.1201085. PMID 9188854.
• Shao Z, Siegert JL, Ruppert S, Robbins PD (Jul 1997). "Rb interacts with TAF(II)250/TFIID through multiple domains". Oncogene 15 (4): 385–92. doi:10.1038/sj.onc.1201204. PMID 9242374.
• Sterner JM, Dew-Knight S, Musahl C, Kornbluth S, Horowitz JM (May 1998). "Negative regulation of DNA replication by the retinoblastoma protein is mediated by its association with MCM7". Molecular and Cellular Biology 18 (5): 2748–57. doi:10.1128/mcb.18.5.2748. PMC 110654. PMID 9566894.
• Woitach JT, Zhang M, Niu CH, Thorgeirsson SS (Aug 1998). "A retinoblastoma-binding protein that affects cell-cycle control and confers transforming ability". Nature Genetics 19 (4): 371–4. doi:10.1038/1258. PMID 9697699.
• Veal E, Eisenstein M, Tseng ZH, Gill G (Sep 1998). "A cellular repressor of E1A-stimulated genes that inhibits activation by E2F". Molecular and Cellular Biology 18 (9): 5032–41. doi:10.1128/mcb.18.9.5032. PMC 109088. PMID 9710587.
• Fusco C, Reymond A, Zervos AS (Aug 1998). "Molecular cloning and characterization of a novel retinoblastoma-binding protein". Genomics 51 (3): 351–8. doi:10.1006/geno.1998.5368. PMID 9721205.
• Ferreira R, Magnaghi-Jaulin L, Robin P, Harel-Bellan A, Trouche D (Sep 1998). "The three members of the pocket proteins family share the ability to repress E2F activity through recruitment of a histone deacetylase". Proceedings of the National Academy of Sciences of the United States of America 95 (18): 10493–8. doi:10.1073/pnas.95.18.10493. PMC 27922. PMID 9724731.
• Paramio JM, Laín S, Segrelles C, Lane EB, Jorcano JL (Aug 1998). "Differential expression and functionally co-operative roles for the retinoblastoma family of proteins in epidermal differentiation". Oncogene 17 (8): 949–57. doi:10.1038/sj.onc.1202031. PMID 9747874.
• Wang S, Ghosh RN, Chellappan SP (Dec 1998). "Raf-1 physically interacts with Rb and regulates its function: a link between mitogenic signaling and cell cycle regulation". Molecular and Cellular Biology 18 (12): 7487–98. doi:10.1128/mcb.18.12.7487. PMC 109329. PMID 9819434.
• Yang R, Müller C, Huynh V, Fung YK, Yee AS, Koeffler HP (Mar 1999). "Functions of cyclin A1 in the cell cycle and its interactions with transcription factor E2F-1 and the Rb family of proteins". Molecular and Cellular Biology 19 (3): 2400–7. doi:10.1128/mcb.19.3.2400. PMC 84032. PMID 10022926.

External links

• RBL2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.