ZNF350

Zinc finger protein 350
Identifiers
Symbols	ZNF350 ; ZBRK1; ZFQR
External IDs	OMIM: 605422 HomoloGene: 130723 GeneCards: ZNF350 Gene
Gene ontology Molecular function • RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding • transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding • DNA binding • protein binding • metal ion binding Cellular component • nucleus • nucleoplasm • nuclear matrix • transcriptional repressor complex Biological process • negative regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated • regulation of transcription, DNA-templated • negative regulation of transcription, DNA-templated Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	59348	n/a
Ensembl	ENSG00000256683	n/a
UniProt	Q9GZX5	n/a
RefSeq (mRNA)	NM_021632	n/a
RefSeq (protein)	NP_067645	n/a
Location (UCSC)	Chr 19: 51.96 – 51.99 Mb	n/a
PubMed search		n/a

Zinc finger protein 350 is a protein that in humans is encoded by the ZNF350 gene.^[1][2][3]

Interactions

ZNF350 has been shown to interact with BRCA1.^[1]

See also

• Zinc finger

References

1. Zheng L, Pan H, Li S, Flesken-Nikitin A, Chen PL, Boyer TG, Lee WH (Oct 2000). "Sequence-specific transcriptional corepressor function for BRCA1 through a novel zinc finger protein, ZBRK1". Molecular Cell 6 (4): 757–68. doi:10.1016/S1097-2765(00)00075-7. PMID 11090615.
2. Ran Q, Wadhwa R, Bischof O, Venable S, Smith JR, Pereira-Smith OM (Feb 2001). "Characterization of a novel zinc finger gene with increased expression in nondividing normal human cells". Experimental Cell Research 263 (1): 156–62. doi:10.1006/excr.2000.5068. PMID 11161714.
3. "Entrez Gene: ZNF350 zinc finger protein 350".

Further reading

• Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Rutter JL, Smith AM, Dávila MR, Sigurdson AJ, Giusti RM, Pineda MA, Doody MM, Tucker MA, Greene MH, Zhang J, Struewing JP (Aug 2003). "Mutational analysis of the BRCA1-interacting genes ZNF350/ZBRK1 and BRIP1/BACH1 among BRCA1 and BRCA2-negative probands from breast-ovarian cancer families and among early-onset breast cancer cases and reference individuals". Human Mutation 22 (2): 121–8. doi:10.1002/humu.10238. PMID 12872252.
• Yun J, Lee WH (Oct 2003). "Degradation of transcription repressor ZBRK1 through the ubiquitin-proteasome pathway relieves repression of Gadd45a upon DNA damage". Molecular and Cellular Biology 23 (20): 7305–14. doi:10.1128/MCB.23.20.7305-7314.2003. PMC 230312. PMID 14517299.
• Tan W, Zheng L, Lee WH, Boyer TG (Feb 2004). "Functional dissection of transcription factor ZBRK1 reveals zinc fingers with dual roles in DNA-binding and BRCA1-dependent transcriptional repression". The Journal of Biological Chemistry 279 (8): 6576–87. doi:10.1074/jbc.M312270200. PMID 14660588.
• Surpili MJ, Delben TM, Kobarg J (Dec 2003). "Identification of proteins that interact with the central coiled-coil region of the human protein kinase NEK1". Biochemistry 42 (51): 15369–76. doi:10.1021/bi034575v. PMID 14690447.
• Li H, Seth A (Mar 2004). "An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein". Oncogene 23 (10): 1801–8. doi:10.1038/sj.onc.1207319. PMID 14755250.
• Tan W, Kim S, Boyer TG (Dec 2004). "Tetrameric oligomerization mediates transcriptional repression by the BRCA1-dependent Kruppel-associated box-zinc finger protein ZBRK1". The Journal of Biological Chemistry 279 (53): 55153–60. doi:10.1074/jbc.M410926200. PMID 15496401.
• Liao G, Huang J, Fixman ED, Hayward SD (Jan 2005). "The Epstein-Barr virus replication protein BBLF2/3 provides an origin-tethering function through interaction with the zinc finger DNA binding protein ZBRK1 and the KAP-1 corepressor". Journal of Virology 79 (1): 245–56. doi:10.1128/JVI.79.1.245-256.2005. PMC 538732. PMID 15596820.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (Jan 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Bulliard Y, Wiznerowicz M, Barde I, Trono D (Nov 2006). "KRAB can repress lentivirus proviral transcription independently of integration site". The Journal of Biological Chemistry 281 (47): 35742–6. doi:10.1074/jbc.M602843200. PMID 16997916.
• Desjardins S, Belleau P, Labrie Y, Ouellette G, Bessette P, Chiquette J, Laframboise R, Lépine J, Lespérance B, Pichette R, Plante M, Durocher F (Jan 2008). "Genetic variants and haplotype analyses of the ZBRK1/ZNF350 gene in high-risk non BRCA1/2 French Canadian breast and ovarian cancer families". International Journal of Cancer. Journal International Du Cancer 122 (1): 108–16. doi:10.1002/ijc.23058. PMID 17764113.

External links

• ZNF350 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.