FOXA2

Forkhead box A2
Identifiers
Symbols	FOXA2 ; HNF3B; TCF3B
External IDs	OMIM: 600288 MGI: 1347476 HomoloGene: 7762 GeneCards: FOXA2 Gene
Gene ontology Molecular function • RNA polymerase II core promoter proximal region sequence-specific DNA binding • RNA polymerase II transcription factor activity, sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding • DNA binding • transcription factor activity, sequence-specific DNA binding • transcription factor binding • protein domain specific binding • transcription regulatory region DNA binding Cellular component • nucleus • cytoplasm Biological process • positive regulation of transcription from RNA polymerase II promoter by glucose • negative regulation of transcription from RNA polymerase II promoter by glucose • in utero embryonic development • ectoderm formation • cell fate specification • regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • adult locomotory behavior • anatomical structure morphogenesis • negative regulation of epithelial to mesenchymal transition • chromatin modification • regulation of steroid metabolic process • cell differentiation in hindbrain • dorsal/ventral neural tube patterning • signal transduction involved in regulation of gene expression • cell differentiation • regulation of blood coagulation • endocrine pancreas development • somite rostral/caudal axis specification • negative regulation of glucokinase activity • positive regulation of embryonic development • negative regulation of sequence-specific DNA binding transcription factor activity • negative regulation of neuron differentiation • positive regulation of neuron differentiation • positive regulation of smoothened signaling pathway • positive regulation of transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter • cell development • neuron fate specification • epithelial tube branching involved in lung morphogenesis • lung epithelial cell differentiation • regulation of insulin secretion involved in cellular response to glucose stimulus • connective tissue development • response to interleukin-6 • dopaminergic neuron differentiation • primitive streak formation • positive regulation of cell-cell adhesion mediated by cadherin • positive regulation of gastrulation • negative regulation of detection of glucose Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3170	15376
Ensembl	ENSG00000125798	ENSMUSG00000037025
UniProt	Q9Y261	P35583
RefSeq (mRNA)	NM_021784	NM_001291065
RefSeq (protein)	NP_068556	NP_001277994
Location (UCSC)	Chr 20: 22.58 – 22.59 Mb	Chr 2: 148.04 – 148.05 Mb
PubMed search

Hepatocyte nuclear factor 3-beta (HNF-3B), also known as forkhead box protein A2 (FOXA2) or transcription factor 3B (TCF-3B) is a protein that in humans is encoded by the FOXA2 gene.^[1][2][3]

Function

Forkhead box protein A2 is a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific genes such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. This gene has been linked to sporadic cases of maturity onset diabetes of the young. Transcript variants encoding different isoforms have been identified for this gene.^[1]

References

1. "Entrez Gene: forkhead box A2".
2. Mincheva A, Lichter P, Schütz G, Kaestner KH (February 1997). "Assignment of the human genes for hepatocyte nuclear factor 3-alpha, -beta, and -gamma (HNF3A, HNF3B, HNF3G) to 14q12-q13, 20p11, and 19q13.2-q13.4". Genomics 39 (3): 417–9. doi:10.1006/geno.1996.4477. PMID 9119385.
3. Wang H, Gauthier BR, Hagenfeldt-Johansson KA, Iezzi M, Wollheim CB (May 2002). "Foxa2 (HNF3beta ) controls multiple genes implicated in metabolism-secretion coupling of glucose-induced insulin release". J. Biol. Chem. 277 (20): 17564–70. doi:10.1074/jbc.M111037200. PMID 11875061.

Further reading

• Zhang Y, Ali TZ, Zhou H; et al. (2010). "ErbB3 binding protein 1 represses metastasis-promoting gene anterior gradient protein 2 in prostate cancer.". Cancer Res. 70 (1): 240–8. doi:10.1158/0008-5472.CAN-09-2904. PMID 20048076.
• Lee HS, Bae EJ, Yi SH; et al. (2010). "Foxa2 and Nurr1 synergistically yield A9 nigral dopamine neurons exhibiting improved differentiation, function, and cell survival.". Stem Cells 28 (3): 501–12. doi:10.1002/stem.294. PMID 20049900.
• Akagi T, Luong QT, Gui D; et al. (2008). "Induction of sodium iodide symporter gene and molecular characterisation of HNF3 beta/FoxA2, TTF-1 and C/EBP beta in thyroid carcinoma cells.". Br. J. Cancer 99 (5): 781–8. doi:10.1038/sj.bjc.6604544. PMC 2528161. PMID 18682709.
• Lamba V, Panetta JC, Strom S, Schuetz EG (2010). "Genetic predictors of interindividual variability in hepatic CYP3A4 expression.". J. Pharmacol. Exp. Ther. 332 (3): 1088–99. doi:10.1124/jpet.109.160804. PMC 2835441. PMID 19934400.
• Popovic J, Klajn A, Petrovic I, Stevanovic M (2010). "Tissue-specific Forkhead protein FOXA2 up-regulates SOX14 gene expression.". Biochim. Biophys. Acta 1799 (5-6): 411–8. doi:10.1016/j.bbagrm.2010.01.002. PMID 20074681.
• Dayoub R, Groitl P, Dobner T; et al. (2010). "Foxa2 (HNF-3beta) regulates expression of hepatotrophic factor ALR in liver cells.". Biochem. Biophys. Res. Commun. 395 (4): 465–70. doi:10.1016/j.bbrc.2010.04.023. PMID 20382118.
• Talmud PJ, Drenos F, Shah S; et al. (2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.". Am. J. Hum. Genet. 85 (5): 628–42. doi:10.1016/j.ajhg.2009.10.014. PMC 2775832. PMID 19913121.
• Tabassum R, Chavali S, Dwivedi OP; et al. (2008). "Genetic variants of FOXA2: risk of type 2 diabetes and effect on metabolic traits in North Indians.". J. Hum. Genet. 53 (11-12): 957–65. doi:10.1007/s10038-008-0335-6. PMID 18797817.
• Bochkis IM, Rubins NE, White P; et al. (2008). "Hepatocyte-specific ablation of Foxa2 alters bile acid homeostasis and results in endoplasmic reticulum stress.". Nat. Med. 14 (8): 828–36. doi:10.1038/nm.1853. PMID 18660816.
• Long Y, Chen E, Liu C; et al. (2009). "The correlation of hepatocyte nuclear factor 4 alpha and 3 beta with hepatitis B virus replication in the liver of chronic hepatitis B patients.". J. Viral Hepat. 16 (8): 537–46. doi:10.1111/j.1365-2893.2009.01089.x. PMID 19302415.
• Banerjee A, Meyer K, Mazumdar B; et al. (2010). "Hepatitis C virus differentially modulates activation of forkhead transcription factors and insulin-induced metabolic gene expression.". J. Virol. 84 (12): 5936–46. doi:10.1128/JVI.02344-09. PMC 2876629. PMID 20357092.
• Ishii K, Yoshida Y, Akechi Y; et al. (2008). "Hepatic differentiation of human bone marrow-derived mesenchymal stem cells by tetracycline-regulated hepatocyte nuclear factor 3beta.". Hepatology 48 (2): 597–606. doi:10.1002/hep.22362. PMID 18666263.
• Song Y, Washington MK, Crawford HC (2010). "Loss of FOXA1/2 is essential for the epithelial-to-mesenchymal transition in pancreatic cancer.". Cancer Res. 70 (5): 2115–25. doi:10.1158/0008-5472.CAN-09-2979. PMC 2831111. PMID 20160041.
• Howell JJ, Stoffel M (2009). "Nuclear export-independent inhibition of Foxa2 by insulin.". J. Biol. Chem. 284 (37): 24816–24. doi:10.1074/jbc.M109.042135. PMC 2757185. PMID 19589781.
• Xing C, Cohen JC, Boerwinkle E (2010). "A weighted false discovery rate control procedure reveals alleles at FOXA2 that influence fasting glucose levels.". Am. J. Hum. Genet. 86 (3): 440–6. doi:10.1016/j.ajhg.2010.01.025. PMC 2833364. PMID 20152958.
• Martin CC, Flemming BP, Wang Y; et al. (2008). "Foxa2 and MafA regulate islet-specific glucose-6-phosphatase catalytic subunit-related protein gene expression.". J. Mol. Endocrinol. 41 (5): 315–28. doi:10.1677/JME-08-0062. PMC 2614309. PMID 18753309.
• Pandey AK, Bhardwaj V, Datta M (2009). "Tumour necrosis factor-alpha attenuates insulin action on phosphoenolpyruvate carboxykinase gene expression and gluconeogenesis by altering the cellular localization of Foxa2 in HepG2 cells.". FEBS J. 276 (14): 3757–69. doi:10.1111/j.1742-4658.2009.07091.x. PMID 19769745.
• Uetzmann L, Burtscher I, Lickert H (2008). "A mouse line expressing Foxa2-driven Cre recombinase in node, notochord, floorplate, and endoderm.". Genesis 46 (10): 515–22. doi:10.1002/dvg.20410. PMID 18798232.
• Bailey SD, Xie C, Do R; et al. (2010). "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.". Diabetes Care 33 (10): 2250–3. doi:10.2337/dc10-0452. PMC 2945168. PMID 20628086.

External links

• FactorBook FOXA2

This article incorporates text from the United States National Library of Medicine, which is in the public domain.