ZEB1

Zinc finger E-box binding homeobox 1
PDB rendering of ZEB1's homeodomain based on 2e19.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2E19​
Identifiers
Symbols	ZEB1 ; AREB6; BZP; DELTAEF1; FECD6; NIL2A; PPCD3; TCF8; ZFHEP; ZFHX1A
External IDs	OMIM: 189909 MGI: 1344313 HomoloGene: 31779 GeneCards: ZEB1 Gene
Gene ontology Molecular function • transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding • chromatin binding • transcription factor activity, sequence-specific DNA binding • transcription coactivator activity • transcription corepressor activity • protein binding • transcription factor binding • zinc ion binding • E-box binding Cellular component • nucleus • nucleoplasm • transcription factor complex • cytoplasm Biological process • negative regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter • immune response • pattern specification process • central nervous system development • cell proliferation • negative regulation of cell proliferation • regulation of mesenchymal cell proliferation • regulation of transforming growth factor beta receptor signaling pathway • negative regulation of epithelial cell differentiation • regulation of T cell differentiation in thymus • positive regulation of neuron differentiation • negative regulation of transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter • embryonic camera-type eye morphogenesis • embryonic skeletal system morphogenesis • semicircular canal morphogenesis • regulation of smooth muscle cell differentiation • cartilage development • cellular response to amino acid stimulus • cochlea morphogenesis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6935	21417
Ensembl	ENSG00000148516	ENSMUSG00000024238
UniProt	P37275	Q64318
RefSeq (mRNA)	NM_001128128	NM_011546
RefSeq (protein)	NP_001121600	NP_035676
Location (UCSC)	Chr 10: 31.32 – 31.53 Mb	Chr 18: 5.59 – 5.78 Mb
PubMed search

Zinc finger E-box-binding homeobox 1 is a protein that in humans is encoded by the ZEB1 gene.^[1][2][3]

TCF8 encodes a human zinc finger transcription factor that represses T-lymphocyte-specific IL2 gene expression by binding to a negative regulatory domain 100 nucleotides 5-prime of the IL2 transcription start site.^[3][4]

Clinical significance

Mutations of the gene are linked to posterior polymorphous corneal dystrophy 3. A recent study suggested its contributing role in lung cancer invasiveness and metastasis development.^[5]

References

1. Williams TM, Montoya G, Wu Y, Eddy RL, Byers MG, Shows TB (Dec 1992). "The TCF8 gene encoding a zinc finger protein (Nil-2-a) resides on human chromosome 10p11.2". Genomics 14 (1): 194–6. doi:10.1016/S0888-7543(05)80307-6. PMID 1427828.
2. Williams TM, Moolten D, Burlein J, Romano J, Bhaerman R, Godillot A, Mellon M, Rauscher FJ, Kant JA (Feb 1992). "Identification of a zinc finger protein that inhibits IL-2 gene expression". Science 254 (5039): 1791–4. doi:10.1126/science.1840704. PMID 1840704.
3. "Entrez Gene: ZEB1 zinc finger E-box binding homeobox 1".
4. Williams TM, Moolten D, Burlein J, Romano J, Bhaerman R, Godillot A, Mellon M, Rauscher FJ, Kant JA (December 1991). "Identification of a zinc finger protein that inhibits IL-2 gene expression". Science 254 (5039): 1791–4. doi:10.1126/science.1840704. PMID 1840704.
5. Liu W, Huang YJ, Liu C, Yang YY, Liu H, Cui JG, Cheng Y, Gao F, Cai JM, Li BL (2014). "Inhibition of TBK1 attenuates radiation-induced epithelial-mesenchymal transition of A549 human lung cancer cells via activation of GSK-3β and repression of ZEB1". Lab. Invest. 94 (4): 362–70. doi:10.1038/labinvest.2013.153. PMID 24468793.

Further reading

• Franklin AJ, Jetton TL, Shelton KD, Magnuson MA (1994). "BZP, a novel serum-responsive zinc finger protein that inhibits gene transcription.". Mol. Cell. Biol. 14 (10): 6773–88. PMC 359208. PMID 7935395.
• Watanabe Y, Kawakami K, Hirayama Y, Nagano K (1994). "Transcription factors positively and negatively regulating the Na,K-ATPase alpha 1 subunit gene.". J. Biochem. 114 (6): 849–55. PMID 8138542.
• Ikeda K, Halle JP, Stelzer G, Meisterernst M, Kawakami K (1998). "Involvement of negative co-factor NC2 in active repression by zinc finger-homeodomain transcription factor AREB6.". Mol. Cell. Biol. 18 (1): 10–8. doi:10.1128/mcb.18.1.10. PMC 121442. PMID 9418848.
• Turner J, Crossley M (1998). "Cloning and characterization of mCtBP2, a co-repressor that associates with basic Krüppel-like factor and other mammalian transcriptional regulators.". EMBO J. 17 (17): 5129–40. doi:10.1093/emboj/17.17.5129. PMC 1170841. PMID 9724649.
• Postigo AA, Dean DC (1999). "ZEB represses transcription through interaction with the corepressor CtBP.". Proc. Natl. Acad. Sci. U.S.A. 96 (12): 6683–8. doi:10.1073/pnas.96.12.6683. PMC 21975. PMID 10359772.
• Hlubek F, Löhberg C, Meiler J, Jung A, Kirchner T, Brabletz T (2001). "Tip60 is a cell-type-specific transcriptional regulator.". J. Biochem. 129 (4): 635–41. doi:10.1093/oxfordjournals.jbchem.a002901. PMID 11275565.
• Locklin RM, Riggs BL, Hicok KC, Horton HF, Byrne MC, Khosla S (2002). "Assessment of gene regulation by bone morphogenetic protein 2 in human marrow stromal cells using gene array technology.". J. Bone Miner. Res. 16 (12): 2192–204. doi:10.1359/jbmr.2001.16.12.2192. PMID 11760832.
• Shaheduzzaman S, Krishnan V, Petrovic A, Bittner M, Meltzer P, Trent J, Venkatesan S, Zeichner S (2002). "Effects of HIV-1 Nef on cellular gene expression profiles.". J. Biomed. Sci. 9 (1): 82–96. doi:10.1007/BF02256581. PMID 11810028.
• Guaita S, Puig I, Franci C, Garrido M, Dominguez D, Batlle E, Sancho E, Dedhar S, De Herreros AG, Baulida J (2002). "Snail induction of epithelial to mesenchymal transition in tumor cells is accompanied by MUC1 repression and ZEB1 expression.". J. Biol. Chem. 277 (42): 39209–16. doi:10.1074/jbc.M206400200. PMID 12161443.
• Costantino ME, Stearman RP, Smith GE, Darling DS (2002). "Cell-specific phosphorylation of Zfhep transcription factor.". Biochem. Biophys. Res. Commun. 296 (2): 368–73. doi:10.1016/S0006-291X(02)00880-X. PMID 12163027.
• Postigo AA (2003). "Opposing functions of ZEB proteins in the regulation of the TGFbeta/BMP signaling pathway.". EMBO J. 22 (10): 2443–52. doi:10.1093/emboj/cdg225. PMC 155983. PMID 12743038.
• Postigo AA, Depp JL, Taylor JJ, Kroll KL (2003). "Regulation of Smad signaling through a differential recruitment of coactivators and corepressors by ZEB proteins.". EMBO J. 22 (10): 2453–62. doi:10.1093/emboj/cdg226. PMC 155984. PMID 12743039.
• Dillner NB, Sanders MM (2004). "Transcriptional activation by the zinc-finger homeodomain protein delta EF1 in estrogen signaling cascades.". DNA Cell Biol. 23 (1): 25–34. doi:10.1089/104454904322745907. PMID 14965470.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Shimizu S, Krafchak C, Fuse N, Epstein MP, Schteingart MT, Sugar A, Eibschitz-Tsimhoni M, Downs CA, Rozsa F, Trager EH, Reed DM, Boehnke M, Moroi SE, Richards JE (2005). "A locus for posterior polymorphous corneal dystrophy (PPCD3) maps to chromosome 10.". Am. J. Med. Genet. A 130 (4): 372–7. doi:10.1002/ajmg.a.30267. PMC 1249494. PMID 15384081.
• Eger A, Aigner K, Sonderegger S, Dampier B, Oehler S, Schreiber M, Berx G, Cano A, Beug H, Foisner R (2005). "DeltaEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells.". Oncogene 24 (14): 2375–85. doi:10.1038/sj.onc.1208429. PMID 15674322.

External links

• FactorBook ZEB1