NFIB (gene)

Nuclear factor I/B
Identifiers
Symbols	NFIB ; CTF; HMGIC/NFIB; NF-I/B; NF1-B; NFI-B; NFI-RED; NFIB2; NFIB3
External IDs	OMIM: 600728 MGI: 103188 HomoloGene: 4087 GeneCards: NFIB Gene
Gene ontology Molecular function • RNA polymerase II core promoter proximal region sequence-specific DNA binding • RNA polymerase II transcription factor activity, sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • RNA polymerase II transcription corepressor activity • DNA binding • double-stranded DNA binding Cellular component • nucleus • nucleoplasm • nucleolus • cerebellar mossy fiber Biological process • negative regulation of transcription from RNA polymerase II promoter • chondrocyte differentiation • DNA replication • transcription from RNA polymerase II promoter • glial cell differentiation • principal sensory nucleus of trigeminal nerve development • anterior commissure morphogenesis • hindbrain development • negative regulation of DNA binding • positive regulation of transcription from RNA polymerase II promoter • Clara cell differentiation • Type I pneumocyte differentiation • Type II pneumocyte differentiation • lung ciliated cell differentiation • commissural neuron axon guidance • negative regulation of mesenchymal cell proliferation involved in lung development • negative regulation of epithelial cell proliferation involved in lung morphogenesis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4781	18028
Ensembl	ENSG00000147862	ENSMUSG00000008575
UniProt	O00712	P97863
RefSeq (mRNA)	NM_001190737	NM_001113209
RefSeq (protein)	NP_001177666	NP_001106680
Location (UCSC)	Chr 9: 14.08 – 14.4 Mb	Chr 4: 82.29 – 82.71 Mb
PubMed search

Nuclear factor 1 B-type is a protein that in humans is encoded by the NFIB gene.^[1][2]

References

1. Qian F, Kruse U, Lichter P, Sippel AE (Dec 1995). "Chromosomal localization of the four genes (NFIA, B, C, and X) for the human transcription factor nuclear factor I by FISH". Genomics 28 (1): 66–73. doi:10.1006/geno.1995.1107. PMID 7590749.
2. "Entrez Gene: NFIB nuclear factor I/B".

Further reading

• Liu Y, Bernard HU, Apt D (1997). "NFI-B3, a novel transcriptional repressor of the nuclear factor I family, is generated by alternative RNA processing.". J. Biol. Chem. 272 (16): 10739–45. doi:10.1074/jbc.272.16.10739. PMID 9099724.
• Geurts JM, Schoenmakers EF, Röijer E, et al. (1998). "Identification of NFIB as recurrent translocation partner gene of HMGIC in pleomorphic adenomas". Oncogene 16 (7): 865–72. doi:10.1038/sj.onc.1201609. PMID 9484777.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Norquay LD, Yang X, Sheppard P, et al. (2003). "RFX1 and NF-1 associate with P sequences of the human growth hormone locus in pituitary chromatin". Mol. Endocrinol. 17 (6): 1027–38. doi:10.1210/me.2003-0025. PMID 12624117.
• Sheeter D, Du P, Rought S, et al. (2003). "Surface CD4 expression modulated by a cellular factor induced by HIV type 1 infection". AIDS Res. Hum. Retroviruses 19 (2): 117–23. doi:10.1089/088922203762688621. PMID 12639247.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Mukhopadhyay SS, Rosen JM (2007). "The C-terminal domain of the Nuclear Factor I-B2 isoform is glycosylated and transactivates the WAP gene in the JEG-3 cells". Biochem. Biophys. Res. Commun. 358 (3): 770–6. doi:10.1016/j.bbrc.2007.04.185. PMC 1942171. PMID 17511965.

External links

• NFIB protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.