ZNF239

Zinc finger protein 239
Identifiers
Symbols	ZNF239 ; HOK-2; MOK2
External IDs	OMIM: 601069 MGI: 1306812 HomoloGene: 68480 GeneCards: ZNF239 Gene
Gene ontology Molecular function • DNA binding • transcription factor activity, sequence-specific DNA binding • RNA binding • protein binding • metal ion binding Cellular component • nucleus Biological process • transcription, DNA-templated • regulation of transcription, DNA-templated Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8187	22685
Ensembl	ENSG00000196793	ENSMUSG00000042097
UniProt	Q16600	P24399
RefSeq (mRNA)	NM_001099282	NM_001001792
RefSeq (protein)	NP_001092752	NP_001001792
Location (UCSC)	Chr 10: 43.56 – 43.57 Mb	Chr 6: 117.86 – 117.87 Mb
PubMed search

Zinc finger protein 239 is a protein that in humans is encoded by the ZNF239 gene.^[1][2][3]

Function

MOK2 proteins are DNA- and RNA-binding proteins that are mainly associated with nuclear RNP components, including the nucleoli and extranucleolar structures.^[3][4]

Interactions

ZNF239 has been shown to interact with LMNA.^[5]

References

1. Arranz V, Kress M, Ernoult-Lange M (Jan 1996). "Localization of zinc finger Mok2 gene to mouse chromosome 6, a new region of homology with human chromosome 19". Mammalian Genome 7 (1): 77–8. doi:10.1007/s003359900020. PMID 8903737.
2. Ernoult-Lange M, Arranz V, Le Coniat M, Berger R, Kress M (Dec 1995). "Human and mouse Krüppel-like (MOK2) orthologue genes encode two different zinc finger proteins". Journal of Molecular Evolution 41 (6): 784–94. doi:10.1007/bf00173158. PMID 8587123.
3. "Entrez Gene: ZNF239 zinc finger protein 239".
4. Arranz V, Harper F, Florentin Y, Puvion E, Kress M, Ernoult-Lange M (Apr 1997). "Human and mouse MOK2 proteins are associated with nuclear ribonucleoprotein components and bind specifically to RNA and DNA through their zinc finger domains". Molecular and Cellular Biology 17 (4): 2116–26. PMC 232059. PMID 9121460.
5. Dreuillet C, Tillit J, Kress M, Ernoult-Lange M (Nov 2002). "In vivo and in vitro interaction between human transcription factor MOK2 and nuclear lamin A/C". Nucleic Acids Research 30 (21): 4634–42. doi:10.1093/nar/gkf587. PMC 135794. PMID 12409453.

Further reading

• Dreuillet C, Tillit J, Kress M, Ernoult-Lange M (Nov 2002). "In vivo and in vitro interaction between human transcription factor MOK2 and nuclear lamin A/C". Nucleic Acids Research 30 (21): 4634–42. doi:10.1093/nar/gkf587. PMC 135794. PMID 12409453.

\* Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (Jan 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.

External links

• ZNF239 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.