HOXC13

Homeobox C13
Identifiers
Symbols	HOXC13 ; ECTD9; HOX3; HOX3G
External IDs	OMIM: 142976 MGI: 99560 HomoloGene: 7770 GeneCards: HOXC13 Gene
Gene ontology Molecular function • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • chromatin binding • protein binding • sequence-specific DNA binding Cellular component • nucleus Biological process • hair follicle development • transcription from RNA polymerase II promoter • anatomical structure morphogenesis • anterior/posterior pattern specification • nail development • tongue morphogenesis • positive regulation of transcription from RNA polymerase II promoter Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3229	15422
Ensembl	ENSG00000123364	ENSMUSG00000001655
UniProt	P31276	P50207
RefSeq (mRNA)	NM_017410	NM_010464
RefSeq (protein)	NP_059106	NP_034594
Location (UCSC)	Chr 12: 53.94 – 53.95 Mb	Chr 15: 102.92 – 102.93 Mb
PubMed search

Homeobox protein Hox-C13 is a protein that in humans is encoded by the HOXC13 gene.^[1][2][3]

Function

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene may play a role in the development of hair, nail, and filiform papilla.^[3]

See also

• Homeobox

References

1. McAlpine PJ, Shows TB (Jul 1990). "Nomenclature for human homeobox genes". Genomics 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
2. Scott MP (Nov 1992). "Vertebrate homeobox gene nomenclature". Cell 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459.
3. "Entrez Gene: HOXC13 homeobox C13".

Further reading

• Godwin AR, Capecchi MR (Dec 1999). "Hair defects in Hoxc13 mutant mice". The Journal of Investigative Dermatology. Symposium Proceedings / the Society for Investigative Dermatology, Inc. [And] European Society for Dermatological Research 4 (3): 244–7. doi:10.1038/sj.jidsp.5640221. PMID 10674376.
• Panagopoulos I, Isaksson M, Billström R, Strömbeck B, Mitelman F, Johansson B (Jan 2003). "Fusion of the NUP98 gene and the homeobox gene HOXC13 in acute myeloid leukemia with t(11;12)(p15;q13)". Genes, Chromosomes & Cancer 36 (1): 107–12. doi:10.1002/gcc.10139. PMID 12461755.
• Acampora D, D'Esposito M, Faiella A, Pannese M, Migliaccio E, Morelli F, Stornaiuolo A, Nigro V, Simeone A, Boncinelli E (Dec 1989). "The human HOX gene family". Nucleic Acids Research 17 (24): 10385–402. doi:10.1093/nar/17.24.10385. PMC 335308. PMID 2574852.
• Rabin M, Ferguson-Smith A, Hart CP, Ruddle FH (Dec 1986). "Cognate homeo-box loci mapped on homologous human and mouse chromosomes". Proceedings of the National Academy of Sciences of the United States of America 83 (23): 9104–8. doi:10.1073/pnas.83.23.9104. PMC 387083. PMID 2878432.
• Apiou F, Flagiello D, Cillo C, Malfoy B, Poupon MF, Dutrillaux B (1996). "Fine mapping of human HOX gene clusters". Cytogenetics and Cell Genetics 73 (1-2): 114–5. doi:10.1159/000134320. PMID 8646877.
• Flagiello D, Gibaud A, Dutrillaux B, Poupon MF, Malfoy B (Oct 1997). "Distinct patterns of all-trans retinoic acid dependent expression of HOXB and HOXC homeogenes in human embryonal and small-cell lung carcinoma cell lines". FEBS Letters 415 (3): 263–7. doi:10.1016/S0014-5793(97)01118-6. PMID 9357979.
• de Stanchina E, Gabellini D, Norio P, Giacca M, Peverali FA, Riva S, Falaschi A, Biamonti G (Jun 2000). "Selection of homeotic proteins for binding to a human DNA replication origin". Journal of Molecular Biology 299 (3): 667–80. doi:10.1006/jmbi.2000.3782. PMID 10835276.
• Kulessa H, Turk G, Hogan BL (Dec 2000). "Inhibition of Bmp signaling affects growth and differentiation in the anagen hair follicle". The EMBO Journal 19 (24): 6664–74. doi:10.1093/emboj/19.24.6664. PMC 305899. PMID 11118201.
• Kosaki K, Kosaki R, Suzuki T, Yoshihashi H, Takahashi T, Sasaki K, Tomita M, McGinnis W, Matsuo N (Feb 2002). "Complete mutation analysis panel of the 39 human HOX genes". Teratology 65 (2): 50–62. doi:10.1002/tera.10009. PMID 11857506.
• Pruett ND, Tkatchenko TV, Jave-Suarez L, Jacobs DF, Potter CS, Tkatchenko AV, Schweizer J, Awgulewitsch A (Dec 2004). "Krtap16, characterization of a new hair keratin-associated protein (KAP) gene complex on mouse chromosome 16 and evidence for regulation by Hoxc13". The Journal of Biological Chemistry 279 (49): 51524–33. doi:10.1074/jbc.M404331200. PMID 15385554.

External links

• HOXC13 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.