ARID3B

AT rich interactive domain 3B (BRIGHT-like)
Identifiers
Symbols	ARID3B ; BDP; DRIL2
External IDs	OMIM: 612457 MGI: 1930768 HomoloGene: 4721 GeneCards: ARID3B Gene
Gene ontology Molecular function • RNA polymerase II core promoter proximal region sequence-specific DNA binding • RNA polymerase II distal enhancer sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding • DNA binding Cellular component • nucleus • nucleoplasm Biological process • transcription from RNA polymerase II promoter • biological_process • positive regulation of transcription from RNA polymerase II promoter Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10620	56380
Ensembl	ENSG00000179361	ENSMUSG00000004661
UniProt	Q8IVW6	Q9Z1N7
RefSeq (mRNA)	NM_001307939	NM_019689
RefSeq (protein)	NP_001294868	NP_062663
Location (UCSC)	Chr 15: 74.54 – 74.6 Mb	Chr 9: 57.79 – 57.84 Mb
PubMed search

AT-rich interactive domain-containing protein 3B is a protein that in humans is encoded by the ARID3B gene.^[1]

Function

This gene encodes a member of the ARID (AT-rich interaction domain) family of DNA-binding proteins. The encoded protein is homologous with two proteins that bind to the retinoblastoma gene product, and also with the mouse Bright and Drosophila dead ringer proteins. A pseudogene on chromosome 1p31 exists for this gene. Members of the ARID family have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation and possibly in chromatin structure modification.^[1]

References

1. "Entrez Gene: ARID3B AT rich interactive domain 3B (BRIGHT-like)".

Further reading

• Kortschak RD, Tucker PW, Saint R (Jun 2000). "ARID proteins come in from the desert". Trends in Biochemical Sciences 25 (6): 294–9. doi:10.1016/S0968-0004(00)01597-8. PMID 10838570.
• Numata S, Claudio PP, Dean C, Giordano A, Croce CM (Aug 1999). "Bdp, a new member of a family of DNA-binding proteins, associates with the retinoblastoma gene product". Cancer Research 59 (15): 3741–7. PMID 10446990.
• Tsai-Tsen Liao, Wen-Hao Hsu, Chien-Hsin Ho (2016). "let-7 Modulates Chromatin Configuration and Target Gene Repression through Regulation of the ARID3B Complex". Cell Reports. doi:10.1016/j.celrep.2015.12.064.

External links

• ARID3B protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.