HLF (gene)
| Hepatic leukemia factor | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | HLF ; MGC33822 | ||||||||||||
| External IDs | OMIM: 142385 MGI: 96108 HomoloGene: 31074 GeneCards: HLF Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 3131 | 217082 | |||||||||||
| Ensembl | ENSG00000108924 | ENSMUSG00000003949 | |||||||||||
| UniProt | Q16534 | Q8BW74 | |||||||||||
| RefSeq (mRNA) | NM_002126 | NM_172563 | |||||||||||
| RefSeq (protein) | NP_002117 | NP_766151 | |||||||||||
| Location (UCSC) |
Chr 17: 55.27 – 55.33 Mb |
Chr 11: 90.34 – 90.39 Mb | |||||||||||
| PubMed search | |||||||||||||
Hepatic leukemia factor is a protein that in humans is encoded by the HLF gene.[1][2]
This monster gene encodes a member of the proline and acidic-rich (PAR) protein family, a subset of the bZIP transcription factors. The encoded protein forms homodimers or heterodimers with other PAR family members and binds sequence-specific promoter elements to activate transcription. Chromosomal translocations fusing portions of this gene with the E2A gene cause a subset of childhood B-lineage acute lymphoid leukemias. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.[2]
References
- ↑ Inaba T, Roberts WM, Shapiro LH, Jolly KW, Raimondi SC, Smith SD, Look AT (Aug 1992). "Fusion of the leucine zipper gene HLF to the E2A gene in human acute B-lineage leukemia". Science 257 (5069): 531–4. doi:10.1126/science.1386162. PMID 1386162.
- 1 2 "Entrez Gene: HLF hepatic leukemia factor".
Further reading
- LeBrun DP (2004). "E2A basic helix-loop-helix transcription factors in human leukemia.". Front. Biosci. 8: s206–22. doi:10.2741/1030. PMID 12700034.
- Hunger SP, Ohyashiki K, Toyama K, Cleary ML (1992). "Hlf, a novel hepatic bZIP protein, shows altered DNA-binding properties following fusion to E2A in t(17;19) acute lymphoblastic leukemia.". Genes Dev. 6 (9): 1608–20. doi:10.1101/gad.6.9.1608. PMID 1516826.
- Falvey E, Fleury-Olela F, Schibler U (1995). "The rat hepatic leukemia factor (HLF) gene encodes two transcriptional activators with distinct circadian rhythms, tissue distributions and target preferences.". EMBO J. 14 (17): 4307–17. PMC 394515. PMID 7556072.
- Hunger SP, Brown R, Cleary ML (1994). "DNA-binding and transcriptional regulatory properties of hepatic leukemia factor (HLF) and the t(17;19) acute lymphoblastic leukemia chimera E2A-HLF.". Mol. Cell. Biol. 14 (9): 5986–96. doi:10.1128/mcb.14.9.5986. PMC 359124. PMID 8065331.
- Inaba T, Shapiro LH, Funabiki T, et al. (1994). "DNA-binding specificity and trans-activating potential of the leukemia-associated E2A-hepatic leukemia factor fusion protein.". Mol. Cell. Biol. 14 (5): 3403–13. PMC 358705. PMID 8164688.
- Hunger SP (1996). "Chromosomal translocations involving the E2A gene in acute lymphoblastic leukemia: clinical features and molecular pathogenesis.". Blood 87 (4): 1211–24. PMID 8608207.
- Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
- Hunger SP, Li S, Fall MZ, et al. (1996). "The proto-oncogene HLF and the related basic leucine zipper protein TEF display highly similar DNA-binding and transcriptional regulatory properties.". Blood 87 (11): 4607–17. PMID 8639829.
- Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags.". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
- Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
- Takahata S, Sogawa K, Kobayashi A, et al. (1998). "Transcriptionally active heterodimer formation of an Arnt-like PAS protein, Arnt3, with HIF-1a, HLF, and clock.". Biochem. Biophys. Res. Commun. 248 (3): 789–94. doi:10.1006/bbrc.1998.9012. PMID 9704006.
- Inukai T, Inaba T, Ikushima S, Look AT (1998). "The AD1 and AD2 transactivation domains of E2A are essential for the antiapoptotic activity of the chimeric oncoprotein E2A-HLF.". Mol. Cell. Biol. 18 (10): 6035–43. PMC 109189. PMID 9742120.
- Begbie M, Mueller C, Lillicrap D (1999). "Enhanced binding of HLF/DBP heterodimers represents one mechanism of PAR protein transactivation of the factor VIII and factor IX genes.". DNA Cell Biol. 18 (2): 165–73. doi:10.1089/104454999315556. PMID 10073576.
- Ema M, Hirota K, Mimura J, et al. (1999). "Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300.". EMBO J. 18 (7): 1905–14. doi:10.1093/emboj/18.7.1905. PMC 1171276. PMID 10202154.
- Honda H, Inaba T, Suzuki T, et al. (1999). "Expression of E2A-HLF chimeric protein induced T-cell apoptosis, B-cell maturation arrest, and development of acute lymphoblastic leukemia.". Blood 93 (9): 2780–90. PMID 10216071.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Matsunaga T, Inaba T, Matsui H, et al. (2004). "Regulation of annexin II by cytokine-initiated signaling pathways and E2A-HLF oncoprotein.". Blood 103 (8): 3185–91. doi:10.1182/blood-2003-09-3022. PMID 15070701.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
External links
- HLF protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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