KDM5D

Lysine (K)-specific demethylase 5D
Rendering based on PDB 2E6R​.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2E6R​, 2YQE​
Identifiers
Symbols	KDM5D ; HY; HYA; JARID1D; SMCY
External IDs	OMIM: 426000 MGI: 99780 HomoloGene: 55838 IUPHAR: 2683 GeneCards: KDM5D Gene
Gene ontology Molecular function • DNA binding • zinc ion binding • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors • histone demethylase activity (H3-K4 specific) Cellular component • cellular_component • nucleoplasm Biological process • chromatin organization • histone H3-K4 demethylation • oxidation-reduction process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8284	20592
Ensembl	ENSG00000012817	ENSMUSG00000056673
UniProt	Q9BY66	Q62240
RefSeq (mRNA)	NM_001146705	NM_011419
RefSeq (protein)	NP_001140177	NP_035549
Location (UCSC)	Chr Y: 19.7 – 19.74 Mb	Chr Y: 0.9 – 0.96 Mb
PubMed search

Lysine-specific demethylase 5D is an enzyme that in humans is encoded by the KDM5D gene.^[1][2][3]

This gene encodes a protein containing zinc finger domains. A short peptide derived from this protein is a minor histocompatibility antigen which can lead to graft rejection of male donor cells in a female recipient.^[3]

References

1. Froggatt P (Feb 1977). "The foundation of the "Inst" medical department and its association with the Belfast Fever Hospital". Ulster Med J 45 (2): 107–45. PMC 2385577. PMID 795123.
2. Kent-First MG, Maffitt M, Muallem A, Brisco P, Shultz J, Ekenberg S, Agulnik AI, Agulnik I, Shramm D, Bavister B, Abdul-Mawgood A, VandeBerg J (Nov 1996). "Gene sequence and evolutionary conservation of human SMCY". Nat Genet 14 (2): 128–9. doi:10.1038/ng1096-128. PMID 8841177.
3. "Entrez Gene: JARID1D jumonji, AT rich interactive domain 1D".

Further reading

• Simpson E, Scott D, Chandler P (1997). "The male-specific histocompatibility antigen, H-Y: a history of transplantation, immune response genes, sex determination and expression cloning.". Annu. Rev. Immunol. 15: 39–61. doi:10.1146/annurev.immunol.15.1.39. PMID 9143681.
• Wolf U (1998). "The serologically detected H-Y antigen revisited.". Cytogenet. Cell Genet. 80 (1–4): 232–5. doi:10.1159/000014986. PMID 9678364.
• Agulnik AI, Mitchell MJ, Lerner JL, et al. (1994). "A mouse Y chromosome gene encoded by a region essential for spermatogenesis and expression of male-specific minor histocompatibility antigens.". Hum. Mol. Genet. 3 (6): 873–8. doi:10.1093/hmg/3.6.873. PMID 7524912.
• Wang W, Meadows LR, den Haan JM, et al. (1995). "Human H-Y: a male-specific histocompatibility antigen derived from the SMCY protein.". Science 269 (5230): 1588–90. doi:10.1126/science.7667640. PMID 7667640.
• Nagase T, Seki N, Ishikawa K, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.". DNA Res. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.
• Agulnik AI, Bishop CE, Lerner JL, et al. (1997). "Analysis of mutation rates in the SMCY/SMCX genes shows that mammalian evolution is male driven.". Mamm. Genome 8 (2): 134–8. doi:10.1007/s003359900372. PMID 9060413.
• Rufer N, Wolpert E, Helg C, et al. (1998). "HA-1 and the SMCY-derived peptide FIDSYICQV (H-Y) are immunodominant minor histocompatibility antigens after bone marrow transplantation.". Transplantation 66 (7): 910–6. doi:10.1097/00007890-199810150-00016. PMID 9798702.
• Lau YF, Zhang J (2000). "Expression analysis of thirty one Y chromosome genes in human prostate cancer.". Mol. Carcinog. 27 (4): 308–21. doi:10.1002/(SICI)1098-2744(200004)27:4<308::AID-MC9>3.0.CO;2-R. PMID 10747295.
• Shen P, Wang F, Underhill PA, et al. (2000). "Population genetic implications from sequence variation in four Y chromosome genes.". Proc. Natl. Acad. Sci. U.S.A. 97 (13): 7354–9. doi:10.1073/pnas.97.13.7354. PMC 16549. PMID 10861003.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Skaletsky H, Kuroda-Kawaguchi T, Minx PJ, et al. (2003). "The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes.". Nature 423 (6942): 825–37. doi:10.1038/nature01722. PMID 12815422.
• Agate RJ, Choe M, Arnold AP (2004). "Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches.". Mol. Biol. Evol. 21 (2): 384–96. doi:10.1093/molbev/msh027. PMID 14660691.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Miklos DB, Kim HT, Miller KH, et al. (2005). "Antibody responses to H-Y minor histocompatibility antigens correlate with chronic graft-versus-host disease and disease remission.". Blood 105 (7): 2973–8. doi:10.1182/blood-2004-09-3660. PMC 1350982. PMID 15613541.
• Piper KP, McLarnon A, Arrazi J, et al. (2007). "Functional HY-specific CD8+ T cells are found in a high proportion of women following pregnancy with a male fetus.". Biol. Reprod. 76 (1): 96–101. doi:10.1095/biolreprod.106.055426. PMID 16988213.
• Iwase S, Lan F, Bayliss P, et al. (2007). "The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases.". Cell 128 (6): 1077–88. doi:10.1016/j.cell.2007.02.017. PMID 17320160.
• Lee MG, Norman J, Shilatifard A, Shiekhattar R (2007). "Physical and functional association of a trimethyl H3K4 demethylase and Ring6a/MBLR, a polycomb-like protein.". Cell 128 (5): 877–87. doi:10.1016/j.cell.2007.02.004. PMID 17320162.

External links

• JARID1D protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.