PAFAH1B2

Platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
PDB rendering based on 1fxw.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1VYH​
Identifiers
Symbols	PAFAH1B2 ; HEL-S-303
External IDs	OMIM: 602508 MGI: 108415 HomoloGene: 1932 ChEMBL: 4463 GeneCards: PAFAH1B2 Gene
EC number	3.1.1.47
Gene ontology Molecular function • 1-alkyl-2-acetylglycerophosphocholine esterase activity • protein homodimerization activity • protein heterodimerization activity • platelet-activating factor acetyltransferase activity Cellular component • nucleolus • cytoplasm • cytosol • plasma membrane • extracellular exosome Biological process • lipid metabolic process • spermatogenesis • brain development • lipid catabolic process • positive regulation of macroautophagy Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5049	18475
Ensembl	ENSG00000168092	ENSMUSG00000003131
UniProt	P68402	Q61206
RefSeq (mRNA)	NM_001184746	NM_008775
RefSeq (protein)	NP_001171675	NP_032801
Location (UCSC)	Chr 11: 117.14 – 117.18 Mb	Chr 9: 45.97 – 45.98 Mb
PubMed search

Platelet-activating factor acetylhydrolase IB subunit beta is an enzyme that in humans is encoded by the PAFAH1B2 gene.^[1][2][3]

Interactions

PAFAH1B2 has been shown to interact with PAFAH1B1.^[4]

See also

• PAFAH1B1
• PAFAH1B3

References

1. Adachi H, Tsujimoto M, Hattori M, Arai H, Inoue K (Apr 1997). "Differential tissue distribution of the beta- and gamma-subunits of human cytosolic platelet-activating factor acetylhydrolase (isoform I)". Biochemical and Biophysical Research Communications 233 (1): 10–3. doi:10.1006/bbrc.1997.6383. PMID 9144386.
2. Moro F, Arrigo G, Fogli A, Bernard L, Carrozzo R (Jul 1998). "The beta and gamma subunits of the human platelet-activating factor acetyl hydrolase isoform Ib (PAFAH1B2 and PAFAH1B3) map to chromosome 11q23 and 19q13.1, respectively". Genomics 51 (1): 157–9. doi:10.1006/geno.1998.5322. PMID 9693049.
3. "Entrez Gene: PAFAH1B2 platelet-activating factor acetylhydrolase, isoform Ib, beta subunit 30kDa".
4. Sweeney KJ, Clark GD, Prokscha A, Dobyns WB, Eichele G (Apr 2000). "Lissencephaly associated mutations suggest a requirement for the PAFAH1B heterotrimeric complex in brain development". Mechanisms of Development 92 (2): 263–71. doi:10.1016/S0925-4773(00)00242-2. PMID 10727864.

Further reading

• Albrecht U, Abu-Issa R, Rätz B, Hattori M, Aoki J, Arai H, Inoue K, Eichele G (Dec 1996). "Platelet-activating factor acetylhydrolase expression and activity suggest a link between neuronal migration and platelet-activating factor". Developmental Biology 180 (2): 579–93. doi:10.1006/dbio.1996.0330. PMID 8954729.
• Sweeney KJ, Clark GD, Prokscha A, Dobyns WB, Eichele G (Apr 2000). "Lissencephaly associated mutations suggest a requirement for the PAFAH1B heterotrimeric complex in brain development". Mechanisms of Development 92 (2): 263–71. doi:10.1016/S0925-4773(00)00242-2. PMID 10727864.
• Sheffield PJ, McMullen TW, Li J, Ho YS, Garrard SM, Derewenda U, Derewenda ZS (Jul 2001). "Preparation and crystal structure of the recombinant alpha(1)/alpha(2) catalytic heterodimer of bovine brain platelet-activating factor acetylhydrolase Ib". Protein Engineering 14 (7): 513–9. doi:10.1093/protein/14.7.513. PMID 11522926.
• Anderson NL, Polanski M, Pieper R, Gatlin T, Tirumalai RS, Conrads TP, Veenstra TD, Adkins JN, Pounds JG, Fagan R, Lobley A (Apr 2004). "The human plasma proteome: a nonredundant list developed by combination of four separate sources". Molecular & Cellular Proteomics 3 (4): 311–26. doi:10.1074/mcp.M300127-MCP200. PMID 14718574.
• Bruneel A, Labas V, Mailloux A, Sharma S, Royer N, Vinh J, Pernet P, Vaubourdolle M, Baudin B (Oct 2005). "Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis". Proteomics 5 (15): 3876–84. doi:10.1002/pmic.200401239. PMID 16130169.
• Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Hasstedt SJ, Scott BT, Rosendaal FR, Callas PW, Vossen CY, Long GL, Bovill EG (Sep 2007). "Exclusion of the alpha2 subunit of platelet-activating factor acetylhydrolase 1b (PAFAH1B2) as a prothrombotic gene in a protein C-deficient kindred and population-based case-control sample". Thrombosis and Haemostasis 98 (3): 587–92. doi:10.1160/th07-02-0134. PMID 17849047.