PAFAH1B3

Platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PDB rendering based on 1bwp.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1bwp​, 1bwq​, 1bwr​, 1es9​, 1fxw​, 1wab​
Identifiers
Symbols	PAFAH1B3 ; PAFAHG
External IDs	OMIM: 603074 MGI: 108414 HomoloGene: 1933 ChEMBL: 5108 GeneCards: PAFAH1B3 Gene
EC number	3.1.1.47
Gene ontology Molecular function • 1-alkyl-2-acetylglycerophosphocholine esterase activity • protein binding • identical protein binding • protein heterodimerization activity • platelet-activating factor acetyltransferase activity Cellular component • cytoplasm • cytosol • membrane • extracellular exosome Biological process • lipid metabolic process • spermatogenesis • nervous system development • brain development • lipid catabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5050	18476
Ensembl	ENSG00000079462	ENSMUSG00000005447
UniProt	Q15102	Q61205
RefSeq (mRNA)	NM_001145939	NM_008776
RefSeq (protein)	NP_001139411	NP_032802
Location (UCSC)	Chr 19: 42.3 – 42.3 Mb	Chr 7: 25.3 – 25.3 Mb
PubMed search

Platelet-activating factor acetylhydrolase IB subunit gamma is an enzyme that in humans is encoded by the PAFAH1B3 gene.^[1][2]

Interactions

PAFAH1B3 has been shown to interact with PAFAH1B1^[3] and LNX1.^[4]

See also

• PAFAH1B1
• PAFAH1B2

References

1. Adachi H, Tsujimoto M, Hattori M, Arai H, Inoue K (Sep 1995). "cDNA cloning of human cytosolic platelet-activating factor acetylhydrolase gamma-subunit and its mRNA expression in human tissues". Biochemical and Biophysical Research Communications 214 (1): 180–7. doi:10.1006/bbrc.1995.2272. PMID 7669037.
2. "Entrez Gene: PAFAH1B3 platelet-activating factor acetylhydrolase, isoform Ib, gamma subunit 29kDa".
3. Sweeney KJ, Clark GD, Prokscha A, Dobyns WB, Eichele G (Apr 2000). "Lissencephaly associated mutations suggest a requirement for the PAFAH1B heterotrimeric complex in brain development". Mechanisms of Development 92 (2): 263–71. doi:10.1016/S0925-4773(00)00242-2. PMID 10727864.
4. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

Further reading

• Moro F, Arrigo G, Fogli A, Bernard L, Carrozzo R (Jul 1998). "The beta and gamma subunits of the human platelet-activating factor acetyl hydrolase isoform Ib (PAFAH1B2 and PAFAH1B3) map to chromosome 11q23 and 19q13.1, respectively". Genomics 51 (1): 157–9. doi:10.1006/geno.1998.5322. PMID 9693049.
• Sweeney KJ, Clark GD, Prokscha A, Dobyns WB, Eichele G (Apr 2000). "Lissencephaly associated mutations suggest a requirement for the PAFAH1B heterotrimeric complex in brain development". Mechanisms of Development 92 (2): 263–71. doi:10.1016/S0925-4773(00)00242-2. PMID 10727864.
• Sheffield PJ, McMullen TW, Li J, Ho YS, Garrard SM, Derewenda U, Derewenda ZS (Jul 2001). "Preparation and crystal structure of the recombinant alpha(1)/alpha(2) catalytic heterodimer of bovine brain platelet-activating factor acetylhydrolase Ib". Protein Engineering 14 (7): 513–9. doi:10.1093/protein/14.7.513. PMID 11522926.
• Saito Y, Doi K, Yamagishi N, Ishihara K, Hatayama T (Feb 2004). "Screening of Hsp105alpha-binding proteins using yeast and bacterial two-hybrid systems". Biochemical and Biophysical Research Communications 314 (2): 396–402. doi:10.1016/j.bbrc.2003.12.108. PMID 14733918.
• Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Guo D, Han J, Adam BL, Colburn NH, Wang MH, Dong Z, Eizirik DL, She JX, Wang CY (Dec 2005). "Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress". Biochemical and Biophysical Research Communications 337 (4): 1308–18. doi:10.1016/j.bbrc.2005.09.191. PMID 16236267.