PDZD2

PDZ domain containing 2
Identifiers
Symbols	PDZD2 ; AIPC; PAPIN; PDZK3; PIN1
External IDs	OMIM: 610697 MGI: 1922394 HomoloGene: 23393 GeneCards: PDZD2 Gene
Gene ontology Molecular function • structural molecule activity • protein binding Cellular component • extracellular region • nucleus • cytoplasm • endoplasmic reticulum • cell-cell junction Biological process • cell adhesion Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23037	68070
Ensembl	ENSG00000133401	ENSMUSG00000022197
UniProt	O15018	E9Q1M1
RefSeq (mRNA)	NM_015022	NM_001081064
RefSeq (protein)	NP_835260	NP_001074533
Location (UCSC)	Chr 5: 31.64 – 32.11 Mb	Chr 15: 12.36 – 12.74 Mb
PubMed search

PDZ domain-containing protein 2 is a protein that in humans is encoded by the PDZD2 gene.^[1][2]

Function

Proteins containing PDZ domains have been shown frequently to bind the C-termini of transmembrane receptors or ion channels. They have also been shown to bind to other PDZ domain proteins and could possibly be involved in intracellular signalling. The protein encoded by this gene contains six PDZ domains and shares sequence similarity with pro-interleukin-16 (pro-IL-16). Like pro-IL-16, the encoded protein localizes to the endoplasmic reticulum and is thought to be cleaved by a caspase to produce a secreted peptide containing two PDZ domains. In addition, this gene is upregulated in primary prostate tumors and may be involved in the early stages of prostate tumorigenesis.^[2]

Interactions

PDZD2 has been shown to interact with PKP4.^[3][4]

References

1. Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (September 1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841.
2. "Entrez Gene: PDZD2 PDZ domain containing 2".
3. Deguchi M, Iizuka T, Hata Y, Nishimura W, Hirao K, Yao I, Kawabe H, Takai Y (September 2000). "PAPIN. A novel multiple PSD-95/Dlg-A/ZO-1 protein interacting with neural plakophilin-related armadillo repeat protein/delta-catenin and p0071". J. Biol. Chem. 275 (38): 29875–80. doi:10.1074/jbc.M005384200. PMID 10896674.
4. Ohno H, Hirabayashi S, Iizuka T, Ohnishi H, Fujita T, Hata Y (October 2002). "Localization of p0071-interacting proteins, plakophilin-related armadillo-repeat protein-interacting protein (PAPIN) and ERBIN, in epithelial cells". Oncogene 21 (46): 7042–9. doi:10.1038/sj.onc.1205852. PMID 12370826.

Further reading

• Lindahl P, Abrahamson M, Björk I (1992). "Interaction of recombinant human cystatin C with the cysteine proteinases papain and actinidin". Biochem. J. 281 ( Pt 1) (Pt 1): 49–55. PMC 1130639. PMID 1731767.
• Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Deguchi M, Iizuka T, Hata Y, Nishimura W, Hirao K, Yao I, Kawabe H, Takai Y (2000). "PAPIN. A novel multiple PSD-95/Dlg-A/ZO-1 protein interacting with neural plakophilin-related armadillo repeat protein/delta-catenin and p0071". J. Biol. Chem. 275 (38): 29875–80. doi:10.1074/jbc.M005384200. PMID 10896674.
• Chaib H, Rubin MA, Mucci NR, Li L, Day ML, Rhim JS, Macoska JA (2001). "Activated in prostate cancer: a PDZ domain-containing protein highly expressed in human primary prostate tumors". Cancer Res. 61 (6): 2390–4. PMID 11289102.
• Ohno H, Hirabayashi S, Iizuka T, Ohnishi H, Fujita T, Hata Y (2002). "Localization of p0071-interacting proteins, plakophilin-related armadillo-repeat protein-interacting protein (PAPIN) and ERBIN, in epithelial cells". Oncogene 21 (46): 7042–9. doi:10.1038/sj.onc.1205852. PMID 12370826.
• Nakayama M, Kikuno R, Ohara O (2002). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
• Yeung ML, Tam TS, Tsang AC, Yao KM (2003). "Proteolytic cleavage of PDZD2 generates a secreted peptide containing two PDZ domains". EMBO Rep. 4 (4): 412–8. doi:10.1038/sj.embor.embor804. PMC 1319160. PMID 12671685.
• Ma RY, Tam TS, Suen AP, Yeung PM, Tsang SW, Chung SK, Thomas MK, Leung PS, Yao KM (2006). "Secreted PDZD2 exerts concentration-dependent effects on the proliferation of INS-1E cells". Int. J. Biochem. Cell Biol. 38 (5-6): 1015–22. doi:10.1016/j.biocel.2005.11.012. PMID 16413998.