PKP4

Plakophilin 4
Identifiers
Symbols PKP4 ; p0071
External IDs OMIM: 604276 MGI: 109281 HomoloGene: 2689 GeneCards: PKP4 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 8502 227937
Ensembl ENSG00000144283 ENSMUSG00000026991
UniProt Q99569 Q68FH0
RefSeq (mRNA) NM_001005476 NM_026361
RefSeq (protein) NP_001005476 NP_080637
Location (UCSC) Chr 2:
158.46 – 158.68 Mb		 Chr 2:
59.16 – 59.36 Mb
PubMed search

Plakophilin-4 is a protein that in humans is encoded by the PKP4 gene.[1][2][3]

Function

Armadillo-like proteins are characterized by a series of armadillo repeats, first defined in the Drosophila 'armadillo' gene product, that are typically 42 to 45 amino acids in length. These proteins can be divided into subfamilies based on their number of repeats, their overall sequence similarity, and the dispersion of the repeats throughout their sequences. Members of the p120(ctn)/plakophilin subfamily of Armadillo-like proteins, including CTNND1, CTNND2, PKP1, PKP2, PKP4, and ARVCF. PKP4 may be a component of desmosomal plaque and other adhesion plaques and is thought to be involved in regulating junctional plaque organization and cadherin function. Multiple transcript variants have been found for this gene, but the full-length nature of only two of them have been described so far. These two variants encode distinct isoforms.[3]

Interactions

PKP4 has been shown to interact with:

References

  1. ↑ Paffenholz R, Franke WW (December 1997). "Identification and localization of a neurally expressed member of the plakoglobin/armadillo multigene family". Differentiation 61 (5): 293–304. doi:10.1046/j.1432-0436.1997.6150293.x. PMID 9342840.
  2. ↑ Hatzfeld M, Nachtsheim C (May 1997). "Cloning and characterization of a new armadillo family member, p0071, associated with the junctional plaque: evidence for a subfamily of closely related proteins". J Cell Sci 109 (11): 2767–78. PMID 8937994.
  3. 1 2 "Entrez Gene: PKP4 plakophilin 4".
  4. ↑ Izawa I, Nishizawa M, Tomono Y, Ohtakara K, Takahashi T, Inagaki M (May 2002). "ERBIN associates with p0071, an armadillo protein, at cell-cell junctions of epithelial cells". Genes Cells 7 (5): 475–85. doi:10.1046/j.1365-2443.2002.00533.x. PMID 12047349.
  5. ↑ Jaulin-Bastard F, Arsanto JP, Le Bivic A, Navarro C, Vély F, Saito H, Marchetto S, Hatzfeld M, Santoni MJ, Birnbaum D, Borg JP (January 2002). "Interaction between Erbin and a Catenin-related protein in epithelial cells". J. Biol. Chem. 277 (4): 2869–75. doi:10.1074/jbc.M109652200. PMID 11711544.
  6. ↑ Laura RP, Witt AS, Held HA, Gerstner R, Deshayes K, Koehler MF, Kosik KS, Sidhu SS, Lasky LA (April 2002). "The Erbin PDZ domain binds with high affinity and specificity to the carboxyl termini of delta-catenin and ARVCF". J. Biol. Chem. 277 (15): 12906–14. doi:10.1074/jbc.M200818200. PMID 11821434.
  7. ↑ Deguchi M, Iizuka T, Hata Y, Nishimura W, Hirao K, Yao I, Kawabe H, Takai Y (September 2000). "PAPIN. A novel multiple PSD-95/Dlg-A/ZO-1 protein interacting with neural plakophilin-related armadillo repeat protein/delta-catenin and p0071". J. Biol. Chem. 275 (38): 29875–80. doi:10.1074/jbc.M005384200. PMID 10896674.
  8. ↑ Ohno H, Hirabayashi S, Iizuka T, Ohnishi H, Fujita T, Hata Y (October 2002). "Localization of p0071-interacting proteins, plakophilin-related armadillo-repeat protein-interacting protein (PAPIN) and ERBIN, in epithelial cells". Oncogene 21 (46): 7042–9. doi:10.1038/sj.onc.1205852. PMID 12370826.
  9. ↑ Stahl B, Diehlmann A, Südhof TC (April 1999). "Direct interaction of Alzheimer's disease-related presenilin 1 with armadillo protein p0071". J. Biol. Chem. 274 (14): 9141–8. doi:10.1074/jbc.274.14.9141. PMID 10092585.

Further reading

  • Keil R, Wolf A, Hüttelmaier S, Hatzfeld M (2007). "Beyond regulation of cell adhesion: local control of RhoA at the cleavage furrow by the p0071 catenin.". Cell Cycle 6 (2): 122–7. doi:10.4161/cc.6.2.3741. PMID 17264675. 
  • Bonné S, van Hengel J, van Roy F (1998). "Chromosomal mapping of human armadillo genes belonging to the p120(ctn)/plakophilin subfamily.". Genomics 51 (3): 452–4. doi:10.1006/geno.1998.5398. PMID 9721216. 
  • Levesque G, Yu G, Nishimura M, Zhang DM, Levesque L, Yu H, Xu D, Liang Y, Rogaeva E, Ikeda M, Duthie M, Murgolo N, Wang L, VanderVere P, Bayne ML, Strader CD, Rommens JM, Fraser PE, St George-Hyslop P (1999). "Presenilins interact with armadillo proteins including neural-specific plakophilin-related protein and beta-catenin.". J. Neurochem. 72 (3): 999–1008. doi:10.1046/j.1471-4159.1999.0720999.x. PMID 10037471. 
  • Stahl B, Diehlmann A, Südhof TC (1999). "Direct interaction of Alzheimer's disease-related presenilin 1 with armadillo protein p0071.". J. Biol. Chem. 274 (14): 9141–8. doi:10.1074/jbc.274.14.9141. PMID 10092585. 
  • Deguchi M, Iizuka T, Hata Y, Nishimura W, Hirao K, Yao I, Kawabe H, Takai Y (2000). "PAPIN. A novel multiple PSD-95/Dlg-A/ZO-1 protein interacting with neural plakophilin-related armadillo repeat protein/delta-catenin and p0071.". J. Biol. Chem. 275 (38): 29875–80. doi:10.1074/jbc.M005384200. PMID 10896674. 
  • Schröder R, van der Ven PF, Warlo I, Schumann H, Fürst DO, Blümcke I, Schmidt MC, Hatzfeld M (2001). "p0071, a member of the armadillo multigene family, is a constituent of sarcomeric I-bands in human skeletal muscle.". J. Muscle Res. Cell. Motil. 21 (6): 577–86. doi:10.1023/A:1026587530656. PMID 11206135. 
  • Jaulin-Bastard F, Arsanto JP, Le Bivic A, Navarro C, Vély F, Saito H, Marchetto S, Hatzfeld M, Santoni MJ, Birnbaum D, Borg JP (2002). "Interaction between Erbin and a Catenin-related protein in epithelial cells.". J. Biol. Chem. 277 (4): 2869–75. doi:10.1074/jbc.M109652200. PMID 11711544. 
  • Izawa I, Nishizawa M, Tomono Y, Ohtakara K, Takahashi T, Inagaki M (2002). "ERBIN associates with p0071, an armadillo protein, at cell-cell junctions of epithelial cells.". Genes Cells 7 (5): 475–85. doi:10.1046/j.1365-2443.2002.00533.x. PMID 12047349. 
  • Ohno H, Hirabayashi S, Iizuka T, Ohnishi H, Fujita T, Hata Y (2002). "Localization of p0071-interacting proteins, plakophilin-related armadillo-repeat protein-interacting protein (PAPIN) and ERBIN, in epithelial cells.". Oncogene 21 (46): 7042–9. doi:10.1038/sj.onc.1205852. PMID 12370826. 
  • Calkins CC, Hoepner BL, Law CM, Novak MR, Setzer SV, Hatzfeld M, Kowalczyk AP (2003). "The Armadillo family protein p0071 is a VE-cadherin- and desmoplakin-binding protein.". J. Biol. Chem. 278 (3): 1774–83. doi:10.1074/jbc.M205693200. PMID 12426320. 
  • Salomon AR, Ficarro SB, Brill LM, Brinker A, Phung QT, Ericson C, Sauer K, Brock A, Horn DM, Schultz PG, Peters EC (2003). "Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry.". Proc. Natl. Acad. Sci. U.S.A. 100 (2): 443–8. doi:10.1073/pnas.2436191100. PMC 141014. PMID 12522270. 
  • Hatzfeld M, Green KJ, Sauter H (2003). "Targeting of p0071 to desmosomes and adherens junctions is mediated by different protein domains.". J. Cell. Sci. 116 (Pt 7): 1219–33. doi:10.1242/jcs.00275. PMID 12615965. 
  • Setzer SV, Calkins CC, Garner J, Summers S, Green KJ, Kowalczyk AP (2004). "Comparative analysis of armadillo family proteins in the regulation of a431 epithelial cell junction assembly, adhesion and migration.". J. Invest. Dermatol. 123 (3): 426–33. doi:10.1111/j.0022-202X.2004.23319.x. PMID 15304078. 
  • Zhang Y, Wolf-Yadlin A, Ross PL, Pappin DJ, Rush J, Lauffenburger DA, White FM (2005). "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules.". Mol. Cell Proteomics 4 (9): 1240–50. doi:10.1074/mcp.M500089-MCP200. PMID 15951569. 
  • Tao WA, Wollscheid B, O'Brien R, Eng JK, Li XJ, Bodenmiller B, Watts JD, Hood L, Aebersold R (2005). "Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry.". Nat. Methods 2 (8): 591–8. doi:10.1038/nmeth776. PMID 16094384. 
  • Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. 


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