PIK3CG

Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PDB rendering based on 17eu.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1E8Y​, 1E8Z​, 1HE8​, 2A4Z​, 2A5U​, 2CHW​, 2CHX​, 2CHZ​, 2V4L​, 3APC​, 3APD​, 3APF​, 3CSF​, 3CST​, 3DBS​, 3DPD​, 3ENE​, 3IBE​, 3L08​, 3L13​, 3L16​, 3L17​, 3L54​, 3LJ3​, 3MJW​, 3ML8​, 3ML9​, 3NZS​, 3NZU​, 3OAW​, 3P2B​, 3PRE​, 3PRZ​, 3PS6​, 3QAQ​, 3QAR​, 3QJZ​, 3QK0​, 3R7Q​, 3R7R​, 3S2A​, 3SD5​, 3T8M​, 3TJP​, 3TL5​, 3ZVV​, 3ZW3​, 4ANU​, 4ANV​, 4ANW​, 4ANX​, 4AOF​, 4DK5​, 4EZJ​, 4EZK​, 4EZL​, 4F1S​, 4FA6​, 4FAD​, 4FHJ​, 4FHK​, 4FJY​, 4FJZ​, 4FLH​, 4FUL​, 4G11​, 4GB9​, 4HLE​, 4HVB​, 4J6I​, 4KZ0​, 4KZC​, 4PS3​, 4PS7​, 4PS8​, 4URK​, 4WWN​, 4WWO​, 4WWP​
Identifiers
Symbols	PIK3CG ; PI3CG; PI3K; PI3Kgamma; PIK3; p110gamma; p120-PI3K
External IDs	OMIM: 601232 MGI: 1353576 HomoloGene: 68269 ChEMBL: 3267 GeneCards: PIK3CG Gene
EC number	2.7.1.153, 2.7.11.1
Gene ontology Molecular function • protein kinase activity • protein serine/threonine kinase activity • protein binding • ATP binding • 1-phosphatidylinositol-3-kinase activity • phosphatidylinositol 3-kinase activity • 1-phosphatidylinositol-4-phosphate 3-kinase activity • ephrin receptor binding • phosphatidylinositol-4,5-bisphosphate 3-kinase activity Cellular component • cytoplasm • cytosol • plasma membrane • phosphatidylinositol 3-kinase complex, class IB • membrane • mast cell granule Biological process • angiogenesis • cytokine production • adaptive immune response • dendritic cell chemotaxis • positive regulation of acute inflammatory response • respiratory burst involved in defense response • protein phosphorylation • phospholipid metabolic process • phosphatidylinositol biosynthetic process • endocytosis • inflammatory response • G-protein coupled receptor signaling pathway • positive regulation of cytosolic calcium ion concentration • blood coagulation • T cell chemotaxis • negative regulation of triglyceride catabolic process • phosphatidylinositol 3-kinase signaling • platelet activation • neutrophil chemotaxis • secretory granule localization • regulation of cell adhesion mediated by integrin • natural killer cell chemotaxis • phosphatidylinositol-3-phosphate biosynthetic process • T cell proliferation • T cell activation • mast cell degranulation • positive regulation of MAP kinase activity • small molecule metabolic process • innate immune response • phosphatidylinositol phosphorylation • positive regulation of protein kinase B signaling • negative regulation of cardiac muscle contraction • platelet aggregation • cellular response to cAMP • neutrophil extravasation • hepatocyte apoptotic process • regulation of calcium ion transmembrane transport • negative regulation of fibroblast apoptotic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5294	30955
Ensembl	ENSG00000105851	ENSMUSG00000020573
UniProt	P48736	Q9JHG7
RefSeq (mRNA)	NM_001282426	NM_001146200
RefSeq (protein)	NP_001269355	NP_001139672
Location (UCSC)	Chr 7: 106.87 – 106.91 Mb	Chr 12: 32.17 – 32.21 Mb
PubMed search

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform is an enzyme that in humans is encoded by the PIK3CG gene.

Function

This gene encodes a protein that belongs to the pi3/pi4-kinase family of proteins. The gene product is an enzyme that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. It is an important modulator of extracellular signals, including those elicited by E-cadherin-mediated cell-cell adhesion, which plays an important role in maintenance of the structural and functional integrity of epithelia. In addition to its role in promoting assembly of adherens junctions, the protein is thought to play a pivotal role in the regulation of cytotoxicity in NK cells. The gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias.^[1]

Interactions

PIK3CG has been shown to interact with:

• BCR gene,^[2][3][4]
• KRAS,^[5]
• PIK3CD,^[6] and
• PIK3R5.^[7]

See also

• Class I PI 3-kinases
• p87PIKAP

References

1. "Entrez Gene: PIK3CG phosphoinositide-3-kinase, catalytic, gamma polypeptide".
2. Bai RY, Jahn T, Schrem S, Munzert G, Weidner KM, Wang JY, Duyster J (August 1998). "The SH2-containing adapter protein GRB10 interacts with BCR-ABL". Oncogene 17 (8): 941–8. doi:10.1038/sj.onc.1202024. PMID 9747873.
3. Salgia R, Sattler M, Pisick E, Li JL, Griffin JD (February 1996). "p210BCR/ABL induces formation of complexes containing focal adhesion proteins and the protooncogene product p120c-Cbl". Exp. Hematol. 24 (2): 310–3. PMID 8641358.
4. Skorski T, Kanakaraj P, Nieborowska-Skorska M, Ratajczak MZ, Wen SC, Zon G, Gewirtz AM, Perussia B, Calabretta B (July 1995). "Phosphatidylinositol-3 kinase activity is regulated by BCR/ABL and is required for the growth of Philadelphia chromosome-positive cells". Blood 86 (2): 726–36. PMID 7606002.
5. Rubio I, Wittig U, Meyer C, Heinze R, Kadereit D, Waldmann H, Downward J, Wetzker R (November 1999). "Farnesylation of Ras is important for the interaction with phosphoinositide 3-kinase gamma". Eur. J. Biochem. 266 (1): 70–82. doi:10.1046/j.1432-1327.1999.00815.x. PMID 10542052.
6. Vanhaesebroeck B, Welham MJ, Kotani K, Stein R, Warne PH, Zvelebil MJ, Higashi K, Volinia S, Downward J, Waterfield MD (April 1997). "P110delta, a novel phosphoinositide 3-kinase in leukocytes". Proc. Natl. Acad. Sci. U.S.A. 94 (9): 4330–5. doi:10.1073/pnas.94.9.4330. PMC 20722. PMID 9113989.
7. Brock C, Schaefer M, Reusch HP, Czupalla C, Michalke M, Spicher K, Schultz G, Nürnberg B (January 2003). "Roles of G beta gamma in membrane recruitment and activation of p110 gamma/p101 phosphoinositide 3-kinase gamma". J. Cell Biol. 160 (1): 89–99. doi:10.1083/jcb.200210115. PMC 2172741. PMID 12507995.

Further reading

• Alloatti G, Montrucchio G, Lembo G, Hirsch E (2004). "Phosphoinositide 3-kinase gamma: kinase-dependent and -independent activities in cardiovascular function and disease.". Biochem. Soc. Trans. 32 (Pt 2): 383–6. doi:10.1042/BST0320383. PMID 15046613.
• Rommel C, Camps M, Ji H (2007). "PI3K delta and PI3K gamma: partners in crime in inflammation in rheumatoid arthritis and beyond?". Nat. Rev. Immunol. 7 (3): 191–201. doi:10.1038/nri2036. PMID 17290298.