PIK3R5

Phosphoinositide-3-kinase, regulatory subunit 5
Identifiers
Symbols	PIK3R5 ; F730038I15Rik; FOAP-2; P101-PI3K; p101
External IDs	OMIM: 611317 MGI: 2443588 HomoloGene: 8627 GeneCards: PIK3R5 Gene
Gene ontology Molecular function • G-protein beta/gamma-subunit complex binding • 1-phosphatidylinositol-3-kinase regulator activity Cellular component • nucleus • cytoplasm • cytosol • phosphatidylinositol 3-kinase complex, class IB • membrane Biological process • phospholipid metabolic process • phosphatidylinositol biosynthetic process • G-protein coupled receptor signaling pathway • blood coagulation • phosphatidylinositol 3-kinase signaling • platelet activation • positive regulation of MAP kinase activity • regulation of phosphatidylinositol 3-kinase activity • small molecule metabolic process • positive regulation of protein kinase B signaling Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23533	320207
Ensembl	ENSG00000141506	ENSMUSG00000020901
UniProt	Q8WYR1	Q5SW28
RefSeq (mRNA)	NM_001142633	NM_177320
RefSeq (protein)	NP_001136105	NP_796294
Location (UCSC)	Chr 17: 8.88 – 8.97 Mb	Chr 11: 68.43 – 68.5 Mb
PubMed search

Phosphoinositide 3-kinase regulatory subunit 5 is an enzyme that in humans is encoded by the PIK3R5 gene.^[1][2]

Interactions

PIK3R5 has been shown to interact with PIK3CG.^[1]

References

1. Brock C, Schaefer M, Reusch HP, Czupalla C, Michalke M, Spicher K, Schultz G, Nurnberg B (Jan 2003). "Roles of G beta gamma in membrane recruitment and activation of p110 gamma/p101 phosphoinositide 3-kinase gamma". J Cell Biol 160 (1): 89–99. doi:10.1083/jcb.200210115. PMC 2172741. PMID 12507995.
2. "Entrez Gene: PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5, p101".

Further reading

• Johnson C, Marriott SJ, Levy LS (2007). "Overexpression of p101 activates PI3Kgamma signaling in T cells and contributes to cell survival". Oncogene 26 (49): 7049–57. doi:10.1038/sj.onc.1210504. PMID 17486067.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Suire S, Coadwell J, Ferguson GJ, et al. (2005). "p84, a new Gbetagamma-activated regulatory subunit of the type IB phosphoinositide 3-kinase p110gamma". Curr. Biol. 15 (6): 566–70. doi:10.1016/j.cub.2005.02.020. PMID 15797027.
• Voigt P, Brock C, Nürnberg B, Schaefer M (2005). "Assigning functional domains within the p101 regulatory subunit of phosphoinositide 3-kinase gamma". J. Biol. Chem. 280 (6): 5121–7. doi:10.1074/jbc.M413104200. PMID 15611065.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Metjian A, Roll RL, Ma AD, Abrams CS (1999). "Agonists cause nuclear translocation of phosphatidylinositol 3-kinase gamma. A Gbetagamma-dependent pathway that requires the p110gamma amino terminus". J. Biol. Chem. 274 (39): 27943–7. doi:10.1074/jbc.274.39.27943. PMID 10488142.
• Krugmann S, Hawkins PT, Pryer N, Braselmann S (1999). "Characterizing the interactions between the two subunits of the p101/p110gamma phosphoinositide 3-kinase and their role in the activation of this enzyme by G beta gamma subunits". J. Biol. Chem. 274 (24): 17152–8. doi:10.1074/jbc.274.24.17152. PMID 10358071.